For student research, this reference highlights the importance of Asian Americans in U.S. history, the impact of specific individuals, and this ethnic group as a whole across time; documenting ...evolving policies, issues, and feelings concerning this particular American population. Asian American History Day by Day: A Reference Guide to Events provides a uniquely interesting way to learn about events in Asian American history that span several hundred years (and the contributions of Asian Americans to U.S. culture in that time). The book is organized in the form of a calendar, with each day of the year corresponding with an entry about an important event, person, or innovation that span several hundred years of Asian American history and references to books and websites that can provide more information about that event. Readers will also have access to primary source document excerpts that accompany the daily entries and serve as additional resources that help bring history to life. With this guide in hand, teachers will be able to more easily incorporate Asian American history into their classes, and students will find the book an easy-to-use guide to the Asian American past and an ideal "jumping-off point" for more targeted research.
Abstract
Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading cause of cancer-associated death worldwide. With the increasing prevalence of metabolic conditions, ...non-alcoholic fatty liver disease (NAFLD) is emerging as the fastest-growing HCC risk factor, and it imposes an additional layer of difficulty in HCC management. Dysregulated hepatic lipids are generally believed to constitute a deleterious environment cultivating the development of NAFLD-associated HCC. However, exactly which lipids or lipid regulators drive this process remains elusive. We report herein that sphingosine kinase 2 (SphK2), a key sphingolipid metabolic enzyme, plays a critical role in NAFLD-associated HCC. Ablation of
Sphk2
suppressed HCC development in NAFLD livers via inhibition of hepatocyte proliferation both in vivo and in vitro. Mechanistically, SphK2 deficiency led to downregulation of ceramide transfer protein (CERT) that, in turn, decreased the ratio of pro-cancer sphingomyelin (SM) to anti-cancer ceramide. Overexpression of CERT restored hepatocyte proliferation, colony growth and cell cycle progression. In conclusion, the current study demonstrates that SphK2 is an essential lipid regulator in NAFLD-associated HCC, providing experimental evidence to support clinical trials of SphK2 inhibitors as systemic therapies against HCC.
Japanese Americans Lee, Jonathan H. X
2017, 2017-11-30, 2017-11-10
eBook
This book provides a comprehensive story of the complicated and rich story of the Japanese American experience-from immigration, to discrimination, to adaptation, achievement and contributions to the ...American mosaic.- Includes more than 200 clearly written, cross-referenced entries that present brief histories on the key people, places, and events associated with Japanese American history- Highlights the distinctive contributions of Japanese Americans to the fabric and plurality of American life- Describes the political, social, and religious institutions founded by Japanese Americans and the community-building, activist, and philanthropic roles they have played- Provides a chronology of events, illustrations, and collection of primary documents
Cancer Diagnoses After Recent Weight Loss Wang, Qiao-Li; Babic, Ana; Rosenthal, Michael H ...
JAMA : the journal of the American Medical Association,
01/2024, Letnik:
331, Številka:
4
Journal Article
Recenzirano
Weight loss is common in primary care. Among individuals with recent weight loss, the rates of cancer during the subsequent 12 months are unclear compared with those without recent weight loss.
To ...determine the rates of subsequent cancer diagnoses over 12 months among health professionals with weight loss during the prior 2 years compared with those without recent weight loss.
Prospective cohort analysis of females aged 40 years or older from the Nurses' Health Study who were followed up from June 1978 until June 30, 2016, and males aged 40 years or older from the Health Professionals Follow-Up Study who were followed up from January 1988 until January 31, 2016.
Recent weight change was calculated from the participant weights that were reported biennially. The intentionality of weight loss was categorized as high if both physical activity and diet quality increased, medium if only 1 increased, and low if neither increased.
Rates of cancer diagnosis during the 12 months after weight loss.
Among 157 474 participants (median age, 62 years IQR, 54-70 years; 111 912 were female 71.1%; there were 2631 participants 1.7% who self-identified as Asian, Native American, or Native Hawaiian; 2678 Black participants 1.7%; and 149 903 White participants 95.2%) and during 1.64 million person-years of follow-up, 15 809 incident cancer cases were identified (incident rate, 964 cases/100 000 person-years). During the 12 months after reported weight change, there were 1362 cancer cases/100 000 person-years among all participants with recent weight loss of greater than 10.0% of body weight compared with 869 cancer cases/100 000 person-years among those without recent weight loss (between-group difference, 493 cases/100 000 person-years 95% CI, 391-594 cases/100 000 person-years; P < .001). Among participants categorized with low intentionality for weight loss, there were 2687 cancer cases/100 000 person-years for those with weight loss of greater than 10.0% of body weight compared with 1220 cancer cases/100 000 person-years for those without recent weight loss (between-group difference, 1467 cases/100 000 person-years 95% CI, 799-2135 cases/100 000 person-years; P < .001). Cancer of the upper gastrointestinal tract (cancer of the esophagus, stomach, liver, biliary tract, or pancreas) was particularly common among participants with recent weight loss; there were 173 cancer cases/100 000 person-years for those with weight loss of greater than 10.0% of body weight compared with 36 cancer cases/100 000 person-years for those without recent weight loss (between-group difference, 137 cases/100 000 person-years 95% CI, 101-172 cases/100 000 person-years; P < .001).
Health professionals with weight loss within the prior 2 years had a significantly higher risk of cancer during the subsequent 12 months compared with those without recent weight loss. Cancer of the upper gastrointestinal tract was particularly common among participants with recent weight loss compared with those without recent weight loss.
Southeast Asian Diaspora in the United States: Memories and Visions, Yesterday, Today, and Tomorrow provides various exploratory interpretations on Southeast Asian American subjectivities, ...communities, histories, creativities, and cultural expressions, as they are revealed, informed, or infused with visions, dreams, and or memories of self in relation to others, places, time, and events - historically significant or quotidian. The interaction and interplay of visions, memories, and subjectivi.
This book represents a follow-up to 2014's The Age of Asian Migration: Continuity, Diversity, and Susceptibility Volume 1. Both volumes are the result of the conference on Asian Migration and ...Diasporas organised by the Southeast Asia Research Centre and held at the City University of Hong Kong in 2013. Despite numerous studies on Asian migration issues having been conducted over the past few decades, no comprehensive account of Asian migrations, especially those taking place since the end of the Second World War exists.While the first volume provided a discussion of a wide spectrum of topics concerning Asian migration - from historical perspectives to updated trends - this volume is organised around three major themes, namely "Women and Migration", "Refugee and Borderland Migration", and "Remittances and Migration Economics".The book contains new migration stories that provide fresh insights into human movements, and enhances academic discussions of migration through case studies from Asia.
A water soluble substance was isolated from a Chinese herb,
Prunella
vulgaris, by hot water extraction, ethanol precipitation and gel permeation column chromatography. Chemical tests showed that the ...substance was an anionic polysaccharide. Using a plaque reduction assay, the polysaccharide at 100 μg/ml was active against the herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), but was inactive against cytomegalovirus, the human influenza virus types A and B, the poliovirus type 1 or the vesicular stomatitis virus. The 50% plaque reduction dose of the polysaccharide for HSV-1 and HSV-2 was 10 μg/ml. Clinical isolates and known acyclovir-resistant (TK-deficient or polymerase-defective) strains of HSV-1 and HSV-2 were similarly inhibited by the polysaccharide. Pre-incubation of HSV-1 with the polysaccharide at 4, 25 or 37°C completely abrogated the infectivity of HSV-1, but pre-treatment of Vero cells with the polysaccharide did not protect cells from infection by the virus. The addition of the polysaccharide at 0, 2, 5.5 and 8 h post-infection of Vero cells with HSV-1 at a multiplicity of infection (MOI) of five reduced the 20 h-yield of intracellular infectious virus by 100, 99, 99 and 94%, respectively. In contrast, a similar addition of heparin showed 85, 63, 53 and 3% reduction of intracellular virus yield, respectively. These results suggest that the polysaccharide may inhibit HSV by competing for cell receptors as well as by some unknown mechanisms after the virus has penetrated the cells. The
Prunella polysaccharide was not cytotoxic to mammalian cells up to the highest concentration tested, 0.5 mg/ml and did not show any anti-coagulant activity. In conclusion, the polysaccharide isolated from
P. vulgaris has specific activity against HSV and its mode of action appears to be different from other anionic carbohydrates, such as heparin.
Editor's Introduction Lee, Jonathan H X
Chinese America, history and perspectives,
01/2016
Journal Article
Recenzirano
First and foremost, we wish to thank you for your continued support of the Chinese Historical Society of America. Margaret Mih Tillman, Ralph Gabbard, Melissa Guy, Liu Qian, and Caroline Fish share ...the unique Chinese Immigrants in Cuba digital repository at Arizona State University, providing an overview of the collection's content and historical importance.
