Meeting users’ preferences and increasing business revenue is an ongoing challenge in the mobile service application. In this paper, we address these challenges by mining mobile user behavior ...patterns and propose an approach to construct a group user portrait by analyzing access data collected from the users of the WeChat Mini Program. We extract the attributes of mobile users considering their geographic information, online duration, and age group. Using Z-score standardized processing and K-means clustering algorithm, we then model the user portraits through three dimensions including daily average duration, interaction intensity, and access frequency. Our analysis has two important features. Firstly, the significant log data used in our experiments was collected from the production environment ensuring that the results reflect the real attributes of WeChat Mini Program users’ behavior. Secondly, we provide data-driven decision-making to help marketers enhance the quality of the product and improve user experience. The experimental results indicate that by distilling and analyzing the key factors from the log data, the characters of typical users can be properly profiled to help product owners better optimize the exact set of the features which need to sustain and further grow.
Inducing apoptosis in cancer cells is considered a potential therapeutic mechanism underlying cancers. Here, chiral folic acid (FA) conjugated Cys-CdTe/CdS quantum dots (QDs) conjugated with a ...cancer-targeting ligand were fabricated to induce apoptosis in vivo. Ligand-induced chirality mechanism for FA-Cys-CdTe/CdS QDs was discussed, which is verified by density functional theory (DFT) simulation. Interestingly, we found that the circular dichroism (CD) signals of chiral QDs can effectively distinguish breast cancer cells from normal cells, where a sharp decrease in CD signal and absorption intensity can be seen. Notably, chiral FA-Cys-CdTe/CdS QDs showed significant apoptosis-inducing ability after the release of mitochondrial apoptotic factors. Furthermore, in vivo experiments showed that chiral FA-Cys-CdTe/CdS QDs provide an efficient cancer ablation through the apoptosis process with negligible toxicity, demonstrating their great potential utility in targeted anticancer agent for future clinic application.
In recent years, deep learning has been widely used in the field of natural language processing (NLP), achieving spectacular successes in various NLP tasks. These successes are largely due to its ...capability to automatically learn feature representations from text data. However, the performance of deep learning in NLP can be negatively affected by a lack of sufficiently large labeled corpus for training, resulting in limited improvement in performance. Data augmentation overcomes this small data problem by expanding the sample size for the classes of data in the training corpus. This paper introduces the data augmentation for aspect-based sentiment analysis (ABSA), a classical research topic in NLP that has been applied in various fileds. The study aims to enhance the classification performance of ABSA through various augmentation strategies. Two specific augmentation strategies are presented,
part-of-speech (PoS) wise synonym substitution
(PWSS) and
dependency relation-based word swap
(DRAWS), which augment data using PoS, external domain knowledge, and syntactic dependency. These strategies are evaluated through extensive experimentation on four public datasets using three representative deep learning models—aspect-specific graph convolutional network (ASGCN), content attention-based aspect-based sentiment classification (CABASC), and long short-term memory (LSTM) network. Compared with the results without data augmentation, our augmentation strategies achieve a performance gain of up to 11.49% on Macro-F1, with the lowest gain being 2.9%. The experimental results demonstrate that the proposed data augmentation strategies are very useful for training deep learning models on small data corpus.
The specific identification and elimination of cancer cells has been a great challenge in the past few decades. In this study, the circular dichroism (CD) of cells was measured by a self-designed ...special system through the folate-conjugated chiral nano-sensor. A novel method was established to recognize cancer cells from normal cells according to the chirality of cells based on their CD signals. After a period of interaction between the nano-sensor and cells, the sharp weakening of CD signals was induced in cancer cells but normal cells remained unchanged. The biocompatibility of the nano-sensor was evaluated and the result showed that it exhibited significant cytotoxic activity against cancer cells while no obvious damage on normal cells. Notably, the research indicated that the nano-sensor may selectively cause apoptosis in cancer cells, and thus, have the potential to act as an antitumor agent.
•The chirality of cells can be measured through Folate-Conjugated CdTe/CdS Quantum Dots.•The special system can discriminate cancer cells from normal cells.•The Nano-Sensor can induce strong cytotoxicity and apoptosis in cancer cells and may act as an antitumor agent.
A novel ITO/NiO/Cu
2
O structure served as photocathodes was applied in photoelectrochemical (PEC) water splitting for the first time. The NiO integration is found to slightly ameliorate the ...crystalline structure of Cu
2
O. PEC measurements showed that NiO-modified Cu
2
O photocathodes can deliver a higher PEC performance, as the photocurrent density was up to − 1.68 mA/cm
2
at − 0.6 V versus RHE under simulated AM 1.5G illumination, which is 2.8 times higher than that of nude one. The enhanced PEC performance may come from the improved charge separation and migration properties of NiO modification.
Novel MoO3-TiO2 composite nanorods films have been successfully prepared by the combination of hydrothermal and electrodeposition method. The composite films show remarkable enhancement of the ...electrochromic properties. In particular, high Li1+ diffusion coefficient (2.0×10−10cm2/s) and a significant optical modulation (50–60% in the range 500–750nm) are achieved for the composite films. The improved electrochromic properties are mainly attributed to the porous space among the nanorods array, which makes the ion diffusion become easier. And it also gives larger surface area for charge-transfer reactions. The data presents great promise for the MoO3-TiO2 composite film as practical electrochromic materials.
•MoO3-TiO2 composite films prepared via hydrothermal and electrodeposition.•The composite films show high Li1+ diffusion coefficient and optical modulation.•The improved properties due to the core/shell structure and high surface area.
Due to the explosive growth of user-generated contents, understanding opinions (such as reviews on products) generated by Internet users is important for optimizing business decision. To achieve such ...understanding, this paper investigates a discriminative approach to classifying opinions according to sentiments. The discriminative approach builds a model with the prior knowledge of the categorization information in order to extract meaningful features from the unstructured texts. The prior knowledge includes ratio factors to reinforce terms’ sentiment polarity by using TF-IDF, short for term frequency-inverse document frequency. Experimental results with four datasets show the proposed approach is very competitive, compared with some of the previous works.
Clinical results from the latest strategies for T-cell activation in cancer have fired interest in combination immunotherapies that can fully engage T-cell immunity. In this study, we describe a ...trastuzumab-based bispecific antibody, HER2-TDB, which targets HER2 and conditionally activates T cells. HER2-TDB specifically killed HER2-expressing cancer cells at low picomolar concentrations. Because of its unique mechanism of action, which is independent of HER2 signaling or chemotherapeutic sensitivity, HER2-TDB eliminated cells refractory to currently approved HER2 therapies. HER2-TDB exhibited potent antitumor activity in four preclinical model systems, including MMTV-huHER2 and huCD3 transgenic mice. PD-L1 expression in tumors limited HER2-TDB activity, but this resistance could be reversed by anti-PD-L1 treatment. Thus, combining HER2-TDB with anti-PD-L1 yielded a combination immunotherapy that enhanced tumor growth inhibition, increasing the rates and durability of therapeutic response.
Fluxgate magnetometer is an important device for weak magnetic-field measurements. By adding a large dc bias excitation current, the performances of fluxgate can be highly improved. In this article, ...based on the assumption of the single-domain state within the probe core wire, the quasi-static Stoner-Wohlfarth model (SW model) was used to construct a mathematic model for the output signal of the orthogonal fluxgate probe operated in fundamental mode (FM-OFG). The dynamic hysteresis loop characteristics were also considered here, and the expected first-harmonic output signal corresponding to the theoretical analysis was obtained from our model. A prototype FM-OFG probe was fabricated by using a 20 mm-long Co-Fe-Nb-Si-B amorphous microwire as core wire and a 1500-turn solenoid as pickup coils. Output performances were analyzed at different external fields, ac excitation currents, and dc bias currents. A good agreement between the modeling results and the experimental ones was found. The noise level was reduced down to 9.01 pT/rt (Hz).@.1 Hz. The simulation method and experiment results provide theoretical guidance for the subsequent design and improvement of the FM-OFG.
The effect of relevant factors on the magnetic properties and structures of FeCuNbSiB nanocrystalline alloy in the tensile stress process was investigated. The continuous annealing apparatus was ...designed to control the tensile stress, annealing temperature, isothermal time, heating rate, and cooling rate. Different levels of relevant factors were performed on the ribbon samples using orthogonal experiments designing and then studied by simple variable controlling. To compare the DC tolerance property, the DC-bias field
H
0.98
is defined. The results show that during annealing the above relevant factors significantly affects the magnetic property including the DC-bias field and core loss. It is observed that the DC-bias field
H
0.98
and the unit weight core loss of alloy
P
m
reach the optimum value in 570 and 590 °C and subsequently deteriorate with the increasing annealing temperature. The DC tolerance property is proportional to the tensile stress and when the tensile stress increasing up to 94 MPa, the DC-bias field
H
0.98
shows a linear relationship with tensile stress. On the other hand, the DC tolerance property is negligible corresponding to the tensile stress smaller than 94 MPa and conversely, the core loss of alloy decrease significantly. The DC-bias field
H
0.98
of annealing samples exhibit a comparably stable value in the time range of 90 s to 900 s. In addition, the core loss
P
m
shows a similarly linear decreasing function with isothermal time from 20 to 900 s. Based on the results, the DC-bias field
H
0.98
is more than 3500 A/m when the tensile stress exceeds 230 MPa and the unit weight of core loss
P
m
is about 63 W/kg corresponding to
f
= 100 kHz and
B
m
= 300 mT when the isothermal time is 900 s, respectively. Analysis with magneto-optical Kerr microscopy reveals that the width of magnetic domains decreases with an increasing tensile stress and annealing temperature. Besides, when the isothermal time exceed 480 s, the magnetic domain wall shows a transformation from perpendicular to parallel to the direction of magnetization. In addition, the relationship between magnetic properties and relevant factors in the tensile stress process is discussed.
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