Green innovation is widely regarded as a beneficial strategy for manufacturing enterprises to accelerate green transformation. Drawing the natural resource-based view with dynamic capabilities, this ...study proposes a model linking green innovation, green dynamic capability, and firm performance. Using survey data from 236 heavy polluting manufacturing firms in China, this study investigates the impact of green innovation on firm performance. The results show that green innovation is positively correlated with both enterprise performance and green dynamic capability, whereas green dynamic capability also has a significant impact on enterprise performance. Furthermore, the survey found that the green resource integration ability, organizational learning capability, and environmental insight capability of green dynamic capability play a moderating effect on the relationship between green innovation and enterprise performance. Additionally, we provide useful enlightenment for policymakers and business managers to stimulate green innovation in enterprises. Our research not only assists managers to better grasp the effects of green innovation practices but also provides some important implications for policymakers.
This paper studies a Balakrishnan–Taylor viscoelastic wave equation with strong time-dependent delay. Under suitable assumptions on the coefficients of the delay term, we establish a generalized ...stability result, which improve some earlier results in the literature.
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Polyurethane (PU) microcapsules containing BMImPF6 as a lubricant have been fabricated by interfacial polymerization. The stabilizing effect of 10 kinds of emulsifiers towards BMImPF6 ...ionic liquid have been delineated. A Pickering emulsion stabilized by lignin showed the best emulsification effect on highly viscous BMImPF6. The types and reactivities of monomers have an important influence on the formation of microcapsules. Three kinds of isocyanate (IPDI, MDI, TDI) were reacted with diamines or diols to prepare the PU microcapsules in this work. The optiaml BMImPF6@PU microcapsules were obtained when using IPDI and TETA as monomers, under conditions of 5,000 rpm emulsifying rate, 0.5 wt% concentration of lignin Pickering emulsion, and a 3:1 mass ratio of BMImPF6/IPDI. The synthesized microcapsules have a regular and compact spherical structure, smooth outer, and inner surfaces with a mean diameter of 43 ± 15 µm, and a thickness of 3.8 µm. The core content of BMImPF6@PU microcapsules was determined as >70%, and the initial decomposition temperature was 300 °C. The BMImPF6 ionic liquid shown excellent lubricating property, ultralow friction coefficient (decreased by 72.7%) and wear rate (decreased by 160 times) were obtained by embedding 30 wt% microcapsules into epoxy compared with pure epoxy.
Osteochondral regeneration with the formation of hyaline cartilage and subchondral bone as well as the integration between the newly formed tissues with the host tissue still remains a great ...challenge. In this study, a construct containing an injectable continuous stratified scaffold and multiple cell systems was designed for enhancing osteochondral regeneration. Briefly, an injectable sodium alginate(SA)/bioglass (BG) composite hydrogel containing bone marrow stem cells (BMSCs) (SA/BG + BMSCs) was used for subchondral bone regeneration and an injectable thermosensitive SA/agarose (AG) composite hydrogel with co-culture of BMSCs and articular chondrocytes (ACs) (SA/AG + ACs/BMSCs) was applied for articular cartilage regeneration. The continuous SA phase and the stratified structure enable the scaffold to mimic the natural osteochondral structure. In addition, the SA/BG + BMSCs hydrogel could enhance the osteoblast differentiation of BMSCs by upregulating their alkaline phosphatase and collagen I gene expressions, and the SA/AG + ACs/BMSCs hydrogel could promote the chondrocyte differentiation of BMSCs by upregulating their Acan and collagen II gene expressions, which indicated that this stratified scaffold could mimic the natural osteochondral function. Furthermore, after the stratified construct was injected into a rat osteochondral defect model, obvious neonatal articular cartilage tissues and subchondral bone tissues with regular surface and highly integration with normal tissues could be observed. This structural and functional biomimetic construct, together with its proper swelling ratio, could not only stimulate the hyaline cartilage and subchondral bone regeneration in an entire osteochondral unit but also promote the integration between the newly formed tissues and the host tissue.
Abstract
Background
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in 2019 and subsequently spread worldwide. Chloroquine has been sporadically used in treating ...SARS-CoV-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late phase in critically ill patients with SARS-CoV-2. Currently, there is no evidence to support the use of hydroxychloroquine in SARS-CoV-2 infection.
Methods
The pharmacological activity of chloroquine and hydroxychloroquine was tested using SARS-CoV-2–infected Vero cells. Physiologically based pharmacokinetic (PBPK) models were implemented for both drugs separately by integrating their in vitro data. Using the PBPK models, hydroxychloroquine concentrations in lung fluid were simulated under 5 different dosing regimens to explore the most effective regimen while considering the drug’s safety profile.
Results
Hydroxychloroquine (EC50 = 0.72 μM) was found to be more potent than chloroquine (EC50 = 5.47 μM) in vitro. Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-CoV-2 infection, as it reached 3 times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance.
Conclusions
Hydroxychloroquine was found to be more potent than chloroquine to inhibit SARS-CoV-2 in vitro.
Hydroxychloroquine was found to be more potent than chloroquine at inhibiting SARS-CoV-2 in vitro. Hydroxychloroquine sulfate 400 mg given twice daily for 1 day, followed by 200 mg twice daily for 4 more days, is recommended to treat SARS-CoV-2 infection.
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The facile and efficient encapsulation of a lubricant oil in SiO2 wrapped polystyrene microcapsules is accomplished using a Pickering polymerization technique. Triton X-100-IPTS fumed ...SiO2 nanoparticles are used as emulsifiers for the formation of O/W Pickering emulsions and the stability factor of the Pickering emulsions was investigated. The as-obtained microcapsules are characterized by scanning electron microscope, thermogravimetric analysis, Fourier transform infrared spectra and dynamic laser scattering. These results suggest that the microcapsules display a spherical shape with a core content of ∼38.3%, an average diameter of 3.3 μm, a shell thickness is ∼900 nm and outstanding thermal stability for lubricant oil with a decomposition temperature of 250 °C. Moreover, the microcapsules are embedded into an epoxy resin for self-lubricating coatings. On the basis of frictional coefficient measurements and wear testing, the self-lubricating microcapsules-incorporated epoxy coatings on an aluminum plate indicate the excellent dispersibility of the microcapsules in coatings and the favorable antifriction effects.
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