Reply to the Editor Sun, LiZhong, MD; Qi, RuiDong, MD
The Journal of thoracic and cardiovascular surgery,
05/2010, Letnik:
139, Številka:
5
Journal Article
Anti-succinate hydroxamates with cyclic P1 motifs were synthesized as aggrecanase inhibitors. The
N-methanesulfonyl piperidine
23 and the
N-trifluoroacetyl azetidine
26 were the most potent ...aggrecanase inhibitors both having an IC
50=3
nM while maintaining >100-fold selectivity over MMP-1, -2, and -9. The cyclic moieties were also capable of altering in vivo metabolism, hence delivering low clearance compounds in both rat and dog studies as shown for compound
14.
Graphic
We demonstrate a polarization independent adiabatic 3-dB coupler for the silicon-on-insulator platform, with a measured bandwidth of 100 nm and power splitting ratios of 3 ± 0.7dB for both the ...transverse electric and transverse magnetic modes.
We demonstrate a broadband sub-wavelength grating coupler for the O-band application, which has a simulated coupling efficiency of -3.3 dB with 3-dB bandwidth of 78 nm and a measured coupling ...efficiency of -4.5 dB with a 3-dB bandwidth of 65 nm for fundamental TE mode.
We demonstrate a compact, single-etched sub-wavelength grating coupler for the O-band application, which has a measured insertion loss of -4 dB, a 3-dB bandwidth of 39 nm, back reflections below -20 ...dB, and a design footprint of 20um × 40um.
We present a novel CSPR controllable silicon photonic transmitter circuit based on a tunable power splitter for VSB self-coherent transmissions. 112 Gb/s 16 QAM over 80 km at a BER below 3.8×10 −3 ...has been achieved.
We present an ultra-broadband and compact asymmetrical beam splitter using subwavelength grating based multi-mode interference coupler. We experimentally demonstrate splitting ratios from 50:50 to ...90:10 over 100 nm bandwidth using a 24μm × 3μm design.
PDF
