Removals of Rhodamine B (RhB) and Acid red 1 using the organic modification of bentonite from aqueous phase were optimized. The organobentonite was synthesized by replacing exchangeable Na+ ions in ...Na-bentonite (Na-Bt) with cetyl trimethylammonium bromide (CTAB) and systematically explored for its adsorption behavior as an efficient adsorbent for the removal of dyes. Batch adsorption studies manifested that the maximum adsorption capacity of dyes were found to be 173.5 mg/g and 157.4 mg/g for RhB and Acid red 1 at the initial concentration of 300 mg/L at 30 °C and pH 9 and 8, respectively. The investigations of adsorption isotherm and kinetics model showed that the adsorption isotherm data were fitted well to the Langmuir isotherm and the adsorption kinetic was better by pseudo-second-order kinetic model. Besides, the thermodynamic parameters indicate that the adsorption process is spontaneous and endothermic. Furthermore, the properties of the obtained samples were characterized by X-ray diffraction (XRD), Scanning electronic microscopy (SEM), Brunauer-Emmett-Teller (BET), Fourier transform infrared spectrometry (FT-IR) and zeta potential analysis. The results of the characterization provided evidence of the morphological properties and how well the adsorption process performed.
图 Schematic diagram of organic modified bentonite and adsorption dyes. Display omitted
•Adsorption ability of different types of dyes onto CTAB-bentonite was investigated.•The relationship of structures and adsorption properties of adsorbent was explored.•The influence of different factors on the properties of the adsorbent was revealed.
•A comprehensive literature review was conducted on CO2-EOR in tight oil reservoirs.•Specialized technologies are needed in the exploitation of China’s tight reservoirs.•The effect of CO2 diffusion ...is relatively exaggerated in experimental results.•CO2-crude oil interaction in nanopores may lead to an oil recovery increment.•CO2-water-minerals interaction influences the geomechanical properties of rock.
Primary oil recovery remains less than 10% in tight oil reservoirs, even after expensive multistage horizontal well hydraulic fracturing stimulation. Substantial experiments and simulation works have been performed to investigate CO2 enhanced oil recovery (CO2-EOR) potential in tight reservoirs; however, some results conflict with each other. The objectives of this paper are to fully understand the CO2-EOR mechanisms and to figure out the difference between tight oil exploitation in North America and China through a comprehensive literature review. It is shown that compared with Bakken and Eagle Ford formation, China’s tight oil reservoirs feature higher mud content and oil viscosity while they have a lower brittleness index of rock and formation pressure coefficient, leading to confined stimulated reservoir volume and further limited CO2-oil contact. The effect of CO2 molecular diffusion is relatively exaggerated in experimental results, which can be attributed to the dual restrictions of exposure time and oil-CO2 area in field scale. Numerical simulation works show that the shifted phase properties in nanopores lead to an oil recovery increment. The development of nano-scale chips withholding high pressure/temperature may advance the experimental study on the nanopore confinement effect. CO2-fluid-rock minerals interaction might be more complex due to the large specific surface area of nanopores in tight formations. The geomechanics coupling effect cannot be ignored when examining the CO2-EOR performance in tight reservoirs. And a comprehensive simulation study coupling with technical and economic feasibility is highly recommended before running a field test of CO2-EOR.
Sirtuin 3 (SIRT3) is reported to be closely relevant to the pathogenesis of psoriasis, but its detailed functions and molecular mechanisms have not been fully studied. Thus, this study aimed to ...investigate the effects and underlying mechanisms by which SIRT3 regulated the development of psoriasis. Specifically, we verified that SIRT3 was aberrantly downregulated in psoriasis-like skin tissues in mice models in vivo and TNF-α-stimulated HaCaT cells in vitro, compared to their corresponding normal counterparts. Functional experiments confirmed that upregulation of SIRT3 triggered cell mitophagy, restrained oxidative stress and inflammation, and inhibited excessive cell proliferation in the TNF-α-stimulated HaCaT cells in vitro, which were all ablated by co-treating cells with the mitophagy inhibitor 3-MA. Subsequently, the mechanism experiments uncovered that elevated SIRT3 deacetylated forkhead box class o 3A (FOXO3a) for its activation, which further activated the Parkin-dependent cell mitophagy in the HaCaT cells. Next, through performing the rescuing experiments, we validated that SIRT3 ameliorated TNF-α-induced psoriasis-associated phenotypes in the HaCaT cells via modulating the FOXO3a/Parkin signal pathway. Collectively, we concluded that SIRT3 triggered cell mitophagy through activating the FOXO3a/Parkin pathway to ameliorate TNF-α-induced psoriasis in the HaCaT cells, and this study provided evidences to support that SIRT3 could be used as important therapeutic target for the treatment of psoriasis.
•A method was proposed by coupling the ERI and the CLUE-S model.•Three different scenarios designed to explore ERI of LUCC in 2027.•Spatiotemporal characteristics of ERI were predicted under ...different scenarios.
The Jinghe County of the Ebinur Lake Basin was chosen as the study area. Based on Landsat TM / OLI images obtained in 2007 and 2017, this paper attempts to use CLUE-S model to predict LUCC under three different scenarios (Natural Development scenario, Farmland Protection scenario, Water Resources Protection scenarios) in 2027. Landscape indices and ecological risk index were calculated and spatially interpolated for the whole region, and the results of ecological risk could be divided into five different zones: extremely low, low, moderate, high and extremely high. They were carried out for assessing the spatial–temporal changes in ecological risk for each landscape pattern. The results show that: (1) Among the three scenarios designed in this paper, the spatial distribution of LUCC in the Water Resource Protection scenario has the most obvious changes, followed by the Farmland Protection scenario and the Natural Development scenario becomes the third. In the water resources protection scenario, the scale of the desert decreases, but the forest and grass part increases, which is conducive to ecological improvement. (2) the distribution area of high ecological risk areas was the largest of three different scenarios, especially the farmland protection scenario. The area of low-risk level is the largest under the water conservation scenario. The ecological risk of LUCC under the water resources protection scenario is lower, which is better for ecological environment. (3) Water bodies mainly concentrate upon low ecological risk degree, accounting for approximately 62.8%, 82.2%, and 73.1% of low ecological risk; Farmland mainly lies in the low-risk areas, accounting for 59.1%, 63.5% and 68.8% of the lower ecological risk levels; In 2027, the unused land and other land types are the main land types of the higher ecological risk areas under three different scenarios, whose proportions are 67.40%, 68.24% and 65.90%, respectively.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that mediate posttranscriptional gene silencing. Mitochondrial fission participates in the induction of apoptosis. It remains largely unknown ...whether miRNAs can regulate mitochondrial fission. Reactive oxygen species and doxorubicin could induce mitochondrial fission and apoptosis in cardiomyocytes. Concomitantly, mitofusin 1 (Mfn1) was downregulated, whereas miRNA 140 (miR-140) was upregulated upon apoptotic stimulation. We investigated whether Mfn1 and miR-140 play a functional role in mitochondrial fission and apoptosis. Ectopic expression of Mfn1 attenuated mitochondrial fission and apoptosis. Knockdown of miR-140 inhibited mitochondrial fission. Our results further revealed that knockdown of miR-140 was able to reduce myocardial infarct sizes in an animal model. We observed that miR-140 could suppress the expression of Mfn1, and it exerted its effect on mitochondrial fission and apoptosis through targeting Mfn1. Our data revealed that mitochondrial fission occurs in cardiomyocytes and can be counteracted by Mfn1. However, the function of Mfn1 is negatively regulated by miR-140. Our present work suggests that Mfn1 and miR-140 are integrated into the program of cardiomyocyte apoptosis.
Mitogen-activated protein kinase kinases (MAPKK) mediate a variety of stress responses in plants. So far little is known on the functional role of MAPKKs in cotton. In the present study, Gossypium ...hirsutum MKK1 (GhMKK1) function was investigated. GhMKK1 protein may activate its specific targets in both the nucleus and cytoplasm. Treatments with salt, drought, and H2O2 induced the expression of GhMKK1 and increased the activity of GhMKK1, while overexpression of GhMKK1 in Nicotiana benthamiana enhanced its tolerance to salt and drought stresses as determined by many physiological data. Additionally, GhMKK1 activity was found to up-regulate pathogen-associated biotic stress, and overexpression of GhMKK1 increased the susceptibility of the transgenic plants to the pathogen Ralstonia solanacearum by reducing the expression of PR genes. Moreover, GhMKK1-overexpressing plants also exhibited an enhanced reactive oxygen species scavenging capability and markedly elevated activities of several antioxidant enzymes. These results indicate that GhMKK1 is involved in plants defence responses and provide new data to further analyze the function of plant MAPK pathways.
The bimodal mesoporous silica modified with 3-aminopropyltriethoxysilane was performed as the aspirin carrier. The samples’ structure, drug loading and release profiles were characterized with X-ray ...diffraction, scanning electron microscopy, N
2 adsorption and desorption, Fourier transform infrared spectroscopy, TG analysis, elemental analysis and UV-spectrophotometer. For further exploring the effects of the bimodal mesopores on the drug delivery behavior, the unimodal mesoporous material MCM-41 was also modified as the aspirin carrier. Meantime, Korsmeyer–Peppas equation
f
t
=
kt
n was employed to analyze the dissolution data in details. It is indicated that the bimodal mesopores are beneficial for unrestricted drug molecules diffusing and therefore lead to a higher loading and faster releasing than that of MCM-41. The results show that the aspirin delivery properties are influenced considerably by the mesoporous matrix, whereas the large pore of bimodal mesoporous silica is the key point for the improved controlled-release properties.
Loading (A) and release profiles (B) of aspirin in N-BMMs and N-MCM-41 indicated that BMMs have more drug loading capacity and faster release rate than that MCM-41.
Display omitted
► Bimodal mesoporous silicas (BMMs) and MCM-41 modified with amino group via post-treatment procedure. ► Loading and release profiles of aspirin in modified BMMs and MCM-41. ► Modified BMMs have more drug loading capacity and faster release rate than that modified MCM-41.
Aerogel fibers, which combine the lightweight and multimesoporous properties of aerogel with the flexible and slender characteristics of the fiber, have received growing attention in the fields of ...smart fabrics, flexible electronic devices, and transparency‐determined optics. Herein a pure Ti3C2Tx MXene aerogel fiber, showing an intriguing oriented mesoporous structure, ultrahigh electrical conductivity, and electrothermal/photothermal dual‐responsiveness, is fabricated via a simple dynamic sol–gel spinning and subsequent supercritical CO2 drying. MXene aerogel fibers exhibit tunable porosity (96.5–99.3%), high specific surface area (up to 142 m2 g−1), and low density (down to 0.035 g cm−3). Benefiting from the metal‐like conductive MXene nanosheets and their high orientation induced by dynamic sol–gel wet spinning, the resultant Ti3C2Tx MXene aerogel fibers display ultrahigh conductivity up to 104 S m−1, which far surpasses the known aerogel materials (including aerogel monoliths, aerogel fibers, and aerogel films) reported in the literature. In addition, MXene aerogel fibers also have excellent electrothermal/photothermal dual‐responsiveness due to high electrical conductivity and remarkable light absorption ability. The combination of these characteristics makes MXene aerogel fibers with encouraging potential in flexible wearable devices, smart fabrics, and portable equipment applications.
A pure Ti3C2Tx MXene aerogel fiber, showing an intriguing oriented mesoporous structure, ultrahigh electrical conductivity, and electrothermal/photonic‐thermal dual‐responsiveness, is fabricated via a simple dynamic sol–gel spinning and subsequent supercritical CO2 drying.
Aerogel fibers garner tremendous scientific interest due to their unique properties such as ultrahigh porosity, large specific surface area, and ultralow thermal conductivity, enabling diverse ...potential applications in textile, environment, energy conversion and storage, and high‐tech areas. Here, the fabrication methodologies to construct the aerogel fibers starting from nanoscale building blocks are overviewed, and the spinning thermodynamics and spinning kinetics associated with each technology are revealed. The huge pool of material choices that can be assembled into aerogel fibers is discussed. Furthermore, the fascinating properties of aerogel fibers, including mechanical, thermal, sorptive, optical, and fire‐retardant properties are elaborated on. Next, the nano‐confining functionalization strategy for aerogel fibers is particularly highlighted, touching upon the driving force for liquid encapsulation, solid–liquid interface adhesion, and interfacial stability. In addition, emerging applications in thermal management, smart wearable fabrics, water harvest, shielding, heat transfer devices, artificial muscles, and information storage, are discussed. Last, the existing challenges in the development of aerogel fibers are pointed out and light is shed on the opportunities in this burgeoning field.
Aerogel fibers emerge as rising stars in diverse fields of thermal management, smart wearable fabrics, water harvest, shielding, heat‐transfer devices, artificial muscles, and information storage. Starting from nanoscale building blocks, spinning thermodynamics and spinning kinetics associated with a variety of technologies are revealed. Aerogel fibers will earn an irreplaceable place with the advances in materials and fabrication methodologies.
Herein, a pH/ultrasound dual‐responsive gas generator is reported, which is based on mesoporous calcium carbonate (MCC) nanoparticles by loading sonosensitizer (hematoporphyrin monomethyl ether ...(HMME)) and modifying surface hyaluronic acid (HA). After pinpointing tumor regions with prominent targeting efficiency, HMME/MCC‐HA decomposes instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound (US) irradiation, concurrently accompanying with CO2 generation and HMME release with spatial/temporal resolution. Afterward, the CO2 bubbling and bursting effect under US stimulus results in cavitation‐mediated irreversible cell necrosis, as well as the blood vessel destruction to further occlude the blood supply, providing a “bystander effect.” Meanwhile, reactive oxygen species generated from HMME can target the apoptotic pathways for effective sonodynamic therapy. Thus, the combination of apoptosis/necrosis with multimechanisms consequently results in a remarkable antitumor therapeutic efficacy, simultaneously minimizing the side effects on major organs. Moreover, the echogenic property of CO2 make the nanoplatform as a powerful ultrasound contrast agent to identify cancerous lesions. Based on the above findings, such all‐in‐one drug delivery platform of HMME/MCC‐HA is utilized to provide the US imaging guidance for therapeutic inertial cavitation and sonodynamic therapy simultaneously, which highlights possibilities of advancing cancer theranostics in biomedical fields.
The sonosensitizer loaded mesoporous calcium carbonate nanoparticles decompose instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound irradiation. The released CO2 and sonosensitizer exploited the merits of synergistic combination of therapeutic inertial cavitation and sonodynamic therapy simultaneously, resulting in antitumor effects with multimechanisms.
PDF
