To investigate determinants of angle width and derive mathematic models to best predict angle width.
Population-based, cross-sectional study.
A total of 1067 Chinese subjects aged ≥40 years.
...Participants underwent gonioscopy, A-scan biometry, and imaging by anterior segment optical coherence tomography (ASOCT, Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure ASOCT parameters. Linear regression modeling was performed with trabecular-iris space area at 750 μm (TISA750) and angle opening distance at 750 μm (AOD750) from the scleral spur as the 2 dependent angle width variables. By using a combination of ASOCT and biometric parameters, an optimal model that was predictive of angle width was determined by a forward selection regression algorithm. Validation of the results was performed in a separate set of community-based clinic study of 1293 persons aged ≥50 years.
Angle width and biometric parameters.
The mean age (standard deviation) of the population-based subjects was 56.9 (8.5) years, and 50.2% were male. For TISA750, the strongest determinants among ASOCT and A-scan independent variables were anterior chamber volume (ACV, R(2)=0.51), followed by anterior chamber area (ACA, R(2)=0.49) and lens vault (LV, R(2)=0.47); for AOD750, these were LV (R(2)=0.56), ACA (R(2)=0.55), and ACV (R(2)=0.54). The R(2) values for anterior chamber depth and axial length were 0.39 and 0.27 for TISA750, respectively, and 0.46 and 0.30 for AOD750, respectively. An optimal model consisting of 6 variables (ACV, ACA, LV, anterior chamber width ACW, iris thickness at 750 μm, and iris area) explained 81.4% of the variability in TISA750 and 85.5% of the variability in AOD750. The results of the population-based study were validated in the community-based clinic study, where the strongest determinants of angle width (ACA, ACV, and LV) and the optimal model with 6 variables were similar.
Angle width is largely dependent on variations in ACA, ACV, and LV. A predictive model comprising 6 quantitative ASOCT parameters explained more than 80% of the variability of angle width and may have implications for screening for angle closure.
Iron-substituted SBA-15 (Fe-SBA-15) materials have been synthesized via a simple direct hydrothermal method under weak acidic conditions. The powder X-ray diffraction (XRD), N
2 sorption and ...transmission electron microscopy (TEM) characterizations show that the resultant materials have well-ordered hexagonal meso-structures. The diffused reflectance UV–vis and UV resonance Raman spectroscopy characterizations show that most of the iron ions exist as isolated framework species for calcined materials when the Fe/Si molar ratios are below 0.01 in the gel. The presence of iron species also has significant salt effects that can greatly improve the ordering of the mesoporous structure. Different iron species including isolated framework iron species, extraframework iron clusters and iron oxides are formed selectively by adjusting the pH values of the synthesis solutions and Fe/Si molar ratios.
We describe a 37-year-old woman who presented with bilateral pleural effusion combined with intermittent low grade fever. Lyme disease was confirmed by seroreactivities against Borrelia burgdorferi ...spirochetes. The unique clinical findings reveal a rare manifestation with a possible association between B. burgdorferi infection and pleural effusion.
Underground Nuclear Astrophysics Experiment in China (JUNA) takes the advantage of the ultra-low background in Jinping underground lab. High current mA level 400 KV accelerator with an ECR source, ...BGO and neutron detectors were commissioned. JUNA studies directly a number of nuclear reactions important to hydrostatic stellar evolution at their relevant stellar energies. In the first quarter of 2021, JUNA performed the direct measurements of
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O near the Gamow window. The experimental results reflect the potential of JUNA with higher statistics, precision and sensitivity of the data. The preliminary results of JUNA experiment and future plan are given.
Bacterial infections routinely cause serious problems to public health. To mitigate the impact of bacterial infections, sensing systems are urgently required for the detection and subsequent ...epidemiological control of pathogenic organisms. Most conventional approaches are time-consuming and highly instrument- and professional operator-dependent. Here, we developed a novel one-component multichannel array constructed with complex systems made from three modified polyethyleneimine as well as negatively charged graphene oxide, which provided an information-rich multimode response to successfully identify 10 bacteria within minutes via electrostatic interactions and hydrophobic interactions. Furthermore, the concentration of bacteria (from OD600 = 0.025 to 1) and the ratio of mixed bacteria were successfully achieved with our smart sensing system. Our designed sensor array also exhibited huge potential in biological samples, such as in urine (OD600 = 0.125, 94% accuracy). The way to construct a sensor array with minimal sensor element with abundant signal outputs tremendously saves cost and time, providing a powerful tool for the diagnosis and assessment of bacterial infections in the clinic.
We have performed the most comprehensive resonance-model fit of π−π−π+ states using the results of our previously published partial-wave analysis (PWA) of a large data set of diffractive-dissociation ...events from the reaction π−+p→π−π−π++precoil with a 190 GeV/c pion beam. The PWA results, which were obtained in 100 bins of three-pion mass, 0.5<m3π<2.5 GeV/c2, and simultaneously in 11 bins of the reduced four-momentum transfer squared, 0.1<t′<1.0 (GeV/c)2, are subjected to a resonance-model fit using Breit-Wigner amplitudes to simultaneously describe a subset of 14 selected waves using 11 isovector light-meson states with JPC=0−+, 1++, 2++, 2−+, 4++, and spin-exotic 1−+ quantum numbers. The model contains the well-known resonances π(1800), a1(1260), a2(1320), π2(1670), π2(1880), and a4(2040). In addition, it includes the disputed π1(1600), the excited states a1(1640), a2(1700), and π2(2005), as well as the resonancelike a1(1420). We measure the resonance parameters mass and width of these objects by combining the information from the PWA results obtained in the 11 t′ bins. We extract the relative branching fractions of the ρ(770)π and f2(1270)π decays of a2(1320) and a4(2040), where the former one is measured for the first time. In a novel approach, we extract the t′ dependence of the intensity of the resonances and of their phases. The t′ dependence of the intensities of most resonances differs distinctly from the t′ dependence of the nonresonant components. For the first time, we determine the t′ dependence of the phases of the production amplitudes and confirm that the production mechanism of the Pomeron exchange is common to all resonances. We have performed extensive systematic studies on the model dependence and correlations of the measured physical parameters.
Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human ...breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.
•One improved method to fabricate embossments on the metal surface was proposed.•The mapping layer must be actively produced to modulate laser-induced shock wave.•Unbalanced load induces material ...flow along the metal surface.•The hardnesses on the entire shocked zone increase due to plastic deformation.•Laser energies, mapping-hole sizes and patterns influence the embossments.
In this paper, we propose one improved method to fabricate micro embossments on the metal surface through laser shock processing. One mapping layer with holes must be actively designed and produced on the metal surface, with which, laser-induced shock wave will be spatially modulated. Laser shock experiments were conducted. Then the surface morphologies, and metallographic microstructures were characterized. The forming process of the micro embossments was simulated with ABAQUS. The results show that under the spatially modulated shock loading, the surface material flows from the high-pressure zone to the low-pressure zone, which is responsible for forming the micro embossments. The shapes, sizes and arrangements of the micro embossments conform to those of the mapping holes. The hardnesses on the entire laser-shocked zones improve remarkably due to the plastic deformation at a high strain rate. The influences of the laser energy and mask pattern on the embossed structures are presented. Within certain limits, increasing laser energy is beneficial for making the embossment more convex. However, further excessively increasing the laser energy, the embossment will exhibit the height saturation due to the pressure rise within the closed mapping hole. The transverse sizes of the mapping holes also can influence the embossment heights significantly. Process parameters need to be chosen carefully to suppress the severe adiabatic compression of the gas within the mapping holes, and then avoid weakening the mechanical properties of the micro embossments. This method has a potential application in manufacturing protruded structures on the metal surface.
The low molecular weight plasma proteome and its biological relevance are not well defined; therefore, experiments were conducted to directly sequence and identify peptides observed in plasma and ...serum protein profiles. Protein fractionation, matrix-assisted laser desorption ionization mass spectrometry (MALDI−MS) profiling, and liquid-chromatography coupled to MALDI tandem mass spectrometry (MS/MS) sequencing were used to analyze the low molecular weight proteome of heparinized plasma. Four fractionation techniques using functionally derivatized 96-well plates were used to extract peptides from plasma. Tandem TOF was successful for identifying peptides up to m/z 5500 with no prior knowledge of the sequence and was also used to verify the sequence assignments for larger ion signals. The peptides (n > 250) sequenced in these profiles came from a surprisingly small number of proteins (n ≈ 20), which were all common to plasma, including fibrinogen, complement components, antiproteases, and carrier proteins. The cleavage patterns were consistent with those of known plasma proteases, including initial cleavages by thrombin, plasmin and complement proteins, followed by aminopeptidase and carboxypeptidase activity. On the basis of these data, we discuss limitations in biomarker discovery in the low molecular weight plasma or serum proteome using crude fractionation coupled to MALDI−MS profiling. Keywords: MALDI TOF/TOF mass spectrometry • low molecular weight plasma proteome
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