Many studies have analyzed the effects of
-cryptoxanthin (BCX) on osteoporosis and bone health. This systematic review and meta-analysis aimed at providing quantitative evidence for the effects of ...BCX on osteoporosis. Publications were selected and retrieved from three databases and carefully screened to evaluate their eligibility. Data from the final 15 eligible studies were extracted and uniformly summarized. Among the 15 studies, seven including 100,496 individuals provided information for the meta-analysis. A random effects model was applied to integrate the odds ratio (OR) to compare the risk of osteoporosis and osteoporosis-related complications between the groups with high and low intake of BCX. A high intake of BCX was significantly correlated with a reduced risk of osteoporosis (OR = 0.79, 95% confidence interval (CI) 0.70-0.90,
= 0.0002). The results remained significant when patients were stratified into male and female subgroups as well as Western and Asian cohorts. A high intake of BCX was also negatively associated with the incidence of hip fracture (OR = 0.71, 95% CI 0.54-0.94,
= 0.02). The results indicate that BCX intake potentially reduces the risk of osteoporosis and hip fracture. Further longitudinal studies are needed to validate the causality of current findings.
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of connective tissue diseases, collectively known as myositis. Diagnosis of IIM is challenging while timely recognition of an IIM is ...of utter importance considering treatment options and otherwise irreversible (severe) long-term clinical complications. With the EULAR/ACR classification criteria (2017) considerable advancement has been made in the diagnostic workup of IIM. While these criteria take into account clinical parameters as well as presence of one autoantibody, anti-Jo-1, several autoantibodies are associated with IIM and are currently evaluated to be incorporated into classification criteria. As individual antibodies occur at low frequency, the development of line blots allowing multiplex antibody analysis has improved laboratory diagnostics for IIM. The Euroline myositis line-blot assay (Euroimmun) allows screening and semi-quantitative measurement for 15 autoantibodies, i.e. myositis specific antibodies (MSA) to SRP, EJ, OJ, Mi-2α, Mi-2β, TIF1-γ, MDA5, NXP2, SAE1, PL-12, PL-7, Jo-1 and myositis associated antibodies (MAA) to Ku, PM/Scl-75 and PM/Scl-100. To evaluate the clinical significance of detection and levels of these autoantibodies in the Netherlands, a retrospective analysis of all Dutch requests for extended myositis screening within a 1 year period was performed. A total of 187 IIM patients and 632 non-IIM patients were included. We conclude that frequencies of MSA and MAA observed in IIM patients in a routine diagnostic setting are comparable to cohort-based studies. Weak positive antibody levels show less diagnostic accuracy compared to positive antibody levels, except for anti-NXP2. Known associations between antibodies and skin involvement (anti-MDA5, anti-TIF1-γ), lung involvement (anti-Jo-1), and malignancy (anti-TIF1-γ) were confirmed in our IIM study population. The availability of multiplex antibody analyses will facilitate inclusion of additional autoantibodies in clinical myositis guidelines and help to accelerate diagnosing IMM with rare but specific antibodies.
•Similar frequency of MAA and MSA in diagnostic setting compared to cohort studies.•Positive levels of MSA/MAA show better diagnostic accuracy compared to weak positive levels.•Anti-NXP2 differentiates already at weak positive level between IIM and non-IIM patients.•Anti-TIF1-γ is associated with malignancy and anti-MDA5 and TIF1-γ with skin disease.•Anti-Jo-1 is associated with lung disease.
In this paper, we study the maximal property of the volume of the convex hull of d-dimensional independent random vectors. We show that the volume of the random convex hull from a multivariate ...location-scale family indexed by Σ is stochastically maximized in simple stochastic order when Σ is diagonal. The claim can be applied to a broad class of multivariate distributions that include skewed/unskewed multivariate t-distributions. We numerically investigate the proven stochastic relationship between the dependent and independent random convex hulls with the Gaussian random convex hull. The numerical results confirm our theoretical findings and the maximal property of the volume of the independent random convex hull.
Cancer detection relying on the release of volatile biomarkers has been extensively studied, but the individual biochemical processes of the cells from which biogenic volatiles originate have not ...been thoroughly elucidated to date. Inadequate determination of the metabolic origin of the volatile biomarkers has limited the progress of the scientific and practical applications of volatile biomarkers. To overcome the current limitations, we developed a metabolism tracking approach combining stable isotope labeling and flux analysis of volatiles to trace the intracellular metabolism-derived volatiles and to reveal their relation to cancer metabolic pathways. Specifically, after the 13C labeling of lung cancer cell, the isotopic ratio of whole cellular carbon was measured by nanoscale secondary ion mass spectrometry-based imaging. The kinetic modeling with the time-dependent isotopic ratio determined the period during which cancer cells reach the metabolic steady state, at which time all of the potential volatiles derived from intracellular metabolism were fully enriched isotopically. By measuring the isotopic enrichment of volatiles at the end-stage of isotopic flux, we found that 2-pentadecanone appeared to be derived from the metabolic cascade starting from glucose to fatty acid synthesis. Furthermore, this biosynthetic pathway was determined to be distinct in cancer, as it was upregulated in colon, breast, and pancreatic cancer cells but not in normal cells. The investigation of the metabolic footprint of 2-pentadecanone demonstrates that our novel approach could be applied to trace the metabolic origin of biogenic volatile organic compounds. This analytical strategy represents a potential cutting-edge tool in elucidating the biochemical authenticity of cancer volatiles and further expanding our understanding of the metabolic network of airborne metabolites in vitro.
In this paper, we provide a frequentist's resolution of the exchange paradox. We propose a probability space with which we can explain both the Bayesian and likelihood-based resolutions. Under the ...proposed probability space, we find the optimal conditional strategy for the game to maximize the expected gain in money, which equals to that in Bayesian resolution. The probability space also allows us to understand that the paradox is from the additional symmetry assumption which is mistakenly taken. We show that the assumption is not feasible, at least in frequentist view, in the sense that no distribution of the money (inside the envelope) exists to satisfy the assumption. This understanding to the paradox is equivalent to the likelihood-based solution by Pawitan (
2001
) that the failure of our reasoning arises from treating the above likelihood function as the probability function and taking expectation over the likelihood function.
Mitochondrial metabolism plays an essential role in various biological processes of cancer cells. Herein, we established an experimental procedure for the metabolic assessment of mitochondria in ...cancer cells. We examined procedures for mitochondrial isolation coupled with various mitochondrial extraction buffers in three major cancer cell lines (PANC1, A549, and MDA-MB-231) and identified a potentially optimal and generalized approach. The purity of the mitochondrial fraction isolated by the selected protocol was verified using specific protein markers of cellular components, and the ultrastructure of the isolated mitochondria was also analyzed by transmission electron microscopy. The isolation procedure, involving a bead beater for cell lysis, a modified sucrose buffer, and differential centrifugation, appeared to be a suitable method for the extraction of mitochondria from cancer cells. Electron micrographs indicated an intact two-layer membrane and inner structures of mitochondria isolated by this procedure. Metabolomic and lipidomic analyses were conducted to examine the metabolic phenotypes of the mitochondria-enriched fractions and associated bulk cancer cells. A total of 44 metabolites, including malate and succinate, occurred at significantly higher levels in the mitochondrial fractions, whereas 51 metabolites, including citrate, oxaloacetate, and fumarate of the Krebs cycle and the oncometabolites glutamine and glutamate, were reduced in mitochondria compared to that in the corresponding bulk cells of PANC1. Similar patterns were observed in mitochondria and bulk cells of MDA-MB-231 and A549 cell lines. A clear difference between the lipid profiles of bulk PANC1, MDA-MB-231, and A549 and corresponding mitochondrial fractions of these cell lines was detected by principal component analysis. In conclusion, we developed an experimental procedure for a large-scale metabolic assessment for suborganelle metabolic profiling and multiple omics data integration in cancer cells with broad applications.
재무 분야에서는 주식 시장에서 투자자들의 행동형태에 대해 많은 연구가 있었다. 본 연구에서는 주식 투자자들의 주식에 대한 관심 정도가 주식의 수익률에 영향을 미치는 효과를 나타내는 관심효과(attention effect)를 실제 자료 분석을 통해 검증하고자 한다. 이러한 효과를 실증적인 자료분석으로부터 검증하기는 쉽지 않았는데, 그 이유는 관심정도를 ...객관화하여 측정하는 것이 어려운 문제였기 때문이다. 그런데, Da 등 (2011)는 구글 검색창에서의 검색빈도로 관심정도를 측정하고, 이를 바탕으로 미국 주식시장에서의 관심효과를 검증하였다. 본 논문에서는 다음커뮤니케이션이 운영하는 주식 채틱방에서 주식종목에 대한 언급횟수에 대한 순위를 통해 관심정도를 측정하고, 언급횟수에 대한 순위가 높을수록 주식의 수익률이 높아졌다고 할 수 있는지 한국 주식시장에서의 관심효과를 검증하고자 하였다. 이를 위해, 관심효과를 순서제약이 있는 가설로 표현하고, 이에 대한 가능도비 검정절차를 제안하였으며 실제 데이터에 적용해 보았다.
Significant research has been conducted in the financial sector on the behavior of investors in the stock market. In this paper, we directly measure the degree of interest using the ranking of the frequency mentioned in the stock message board operated by Daum Communications Corp. and test the fact that the higher ranking of the frequency results in the higher stock returns in order to investigate the attention effect on the stock returns in the Korean stock market. We also propose and apply the likelihood ratio test procedure for order restricted hypotheses in order to test the attention effect. The test results shows that the higher rank in the frequency mentioned in the message board is related to stock returns (p-value < 10 -6 ). Therefore, we conclude that an investors’ attention effects exist in the Korean stock market.
The path algorithm of the fused lasso signal approximator is known to fail in finding change points when monotonically increasing or decreasing blocks exist in the mean vector. In this paper, we ...first understand why the standard path algorithm by Hoefling (2010) fails in the primal optimization problem. We then propose a modified path algorithm for the consistent recovery of the change points and study its properties theoretically and numerically.
•The path algorithm for fused lasso signal approximator fails in finding change points when monotonic blocks exist in the mean vector.•We understand why the standard path algorithm in the literature fails in the primal optimization problem.•We propose a modified path algorithm for the consistent recovery of the change points.
In this paper, we study non-asymptotic convergence rate of the inverse probability weight estimator of covariance matrix when some values of the data are missing completely at random.
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