The use of lanthanide elements for applications in various industries such as the chemical industry and in biomedical engineering is examined. Topics discussed include lanthanide nanoparticles as MRI ...contrast agents, lanthanide upconversion nanoparticles for biosensing, bioimaging, and therapy and nanoceria for nanomedicine.
The combination of photoredox and enzymatic catalysis for the direct asymmetric one‐pot synthesis of 2,2‐disubstituted indol‐3‐ones from 2‐arylindoles through concurrent oxidization and alkylation ...reactions is described. 2‐Arylindoles can be photocatalytically oxidized to 2‐arylindol‐3‐one with subsequent enantioselective alkylation with ketones catalyzed by wheat germ lipase (WGL). The chiral quaternary carbon center at C2 of the indoles was directly constructed. This mode of concurrent photobiocatalysis provides a mild and powerful strategy for one‐pot enantioselective synthesis of complex compounds. The experiments proved that other lipases containing structurally analogous catalytic triad in the active site also can catalyze the reaction in the same way. This reaction is the first example of combining the non‐natural catalytic activity of hydrolases with visible‐light catalysis for enantioselective organic synthesis and it does not require any cofactors.
Look, no cofactors! The combination of photoredox and enzymatic catalysis enables the direct asymmetric one‐pot synthesis of C2‐quaternary indolin‐3‐ones from 2‐arylindoles. This reaction is the first example of combining the non‐natural catalytic activity of hydrolases with visible‐light catalysis for enantioselective organic synthesis, and it does not require any cofactors.
SIRT1 and HIF1α are regarded as two key metabolic sensors in cellular metabolism pathways and play vital roles in influencing immune responses. SIRT1 and HIF1α regulate immune responses in ...metabolism-dependent and -independent ways. Here, we summarized the recent knowledge of SIRT1 and HIF1α signaling in metabolism and immune responses. HIF1α is a direct target of SIRT1. Sometimes, SIRT1 and HIF1α cooperate or act separately to mediate immune responses. In innate immune responses, SIRT1 can regulate the glycolytic activity of myeloid-derived suppressor cells (MDSCs) and influence MDSC functional differentiation. SIRT1 can regulate monocyte function through NF-κB and PGC-1, accompanying an increased NAD+ level. The SIRT1-HIF1α axis bridges the innate immune signal to an adaptive immune response by directing cytokine production of dendritic cells in a metabolism-independent manner, promoting the differentiation of CD4+ T cells. For adaptive immune cells, SIRT1 can mediate the differentiation of inflammatory T cell subsets in a NAD+-dependent manner. HIF1α can stimulate some glycolysis-associated genes and regulate the ATP and ROS generations. In addition, SIRT1-and HIF1α-associated metabolism inhibits the activity of mTOR, thus negatively regulating the differentiation and function of Th9 cells. As immune cells are crucial in controlling immune-associated diseases, SIRT1-and HIF1α associated-metabolism is closely linked to immune-associated diseases, including infection, tumors, allergic airway inflammation, and autoimmune diseases.
•SIRT1-HIF1α axis can regulate glycolytic activity of innate immune cells and influence their functional differentiation.•SIRT1-HIF1α axis bridges the innate immune signal to adaptive immunity in promoting the differentiation of CD4+T cells.•SIRT1-HIF1α axis can mediate the differentiation and inflammatory T cell subsets in a NAD+ dependent manner.•SIRT1 and HIF1α associated metabolism is closely linked to immune-associated diseases.
Lignin is the most abundant biopolymer with aromatic building blocks and its valorization to sustainable chemicals and fuels has extremely great potential to reduce the excessive dependence on fossil ...resources, although such conversions remain challenging. The purpose of this Review is to present an insight into the catalytic conversion of lignin involving hydrogen, including reductive depolymerization and the hydrodeoxygenation of lignin‐derived monomers to arenes, cycloalkanes and phenols, with a main focus on the catalyst systems and reaction mechanisms. The roles of hydrogenation sites (Ru, Pt, Pd, Rh) and acid sites (Nb, Ti, Mo), as well as their interaction in selective hydrodeoxygenation reactions are emphasized. Furthermore, some inspirational strategies for the production of other value‐added chemicals are mentioned. Finally, some personal perspectives are provided to highlight the opportunities within this attractive field.
Getting better with H: This Review presents an insight into the catalytic conversion of lignin involving hydrogen, including reductive depolymerization and hydrodeoxygenation of lignin‐derived monomers, with a focus on catalyst systems and reaction mechanisms. The roles of hydrogenation sites and acid sites, strategies for the production of other value‐added chemicals, and future opportunities within this attractive field are discussed.
The skin is the largest organ of the human body and can sense pressure, temperature, and other complex environmental stimuli or conditions. The mimicry of human skin's sensory ability via electronics ...is a topic of innovative research that could find broad applications in robotics, artificial intelligence, and human–machine interfaces, all of which promote the development of electronic skin (e‐skin). To imitate tactile sensing via e‐skins, flexible and stretchable pressure sensor arrays are constructed based on different transduction mechanisms and structural designs. These arrays can map pressure with high resolution and rapid response beyond that of human perception. Multi‐modal force sensing, temperature, and humidity detection, as well as self‐healing abilities are also exploited for multi‐functional e‐skins. Other recent progress in this field includes the integration with high‐density flexible circuits for signal processing, the combination with wireless technology for convenient sensing and energy/data transfer, and the development of self‐powered e‐skins. Future opportunities lie in the fabrication of highly intelligent e‐skins that can sense and respond to variations in the external environment. The rapidly increasing innovations in this area will be important to the scientific community and to the future of human life.
Electronic skins (e‐skins) that mimic the sensory ability of human skin have recently emerged as a research hotspot due to their promising applications in biomimetic robotics, prosthetics, and other applications. Soft tactile sensor arrays are used in e‐skins for high‐quality pressure mapping, and more comprehensive functional modules are under development. Continuous innovations in this field will advance the practical usability of e‐skins.
Volatile organic compounds (VOCs) are harmful for human and surrounding ecosystem, and a great number of VOC abatement technologies have been developed during the past few decades. However, the ...single method has some problems such as high energy consumption, unfriendly environment, and low removal efficiency. Recently, the integration of adsorption and photocatalytic degradation of VOCs is considered as a promising one. Carbon material, with large surface area, high adsorption capacity, and fast electron transfer ability, is widely used in integrated adsorptive-photocatalytic removal of VOCs. It is thus crucial to digest and summarize recent research advances in carbon-based nanocomposites as the adsorbent-photocatalyst for VOC removal. To satisfy this need, this work provides a critical review of the related literature with focuses on: (1) the advantages and disadvantages of various carbon-based nanocomposites for the applications of VOC adsorption and photocatalytic degradation; (2) models and mechanisms of adsorptive-photocatalytic removal of VOCs according to the material properties; and (3) major factors controlling adsorption-photocatalysis processes of VOCs. The review is aimed to establish the “structure-property-application” relationships for the development of innovative carbon-supported nanocomposites and to promote future research on the integrated adsorptive and photocatalytic removal of VOCs.
•The advantages and disadvantages of carbon-supported hybrids were discussed.•Adsorption and photocatalytic models of VOC removal were reviewed.•The reaction processes and intermediates were proposed.•Major factors controlling adsorptive-photocatalytic reactions were discussed.
In response to different microenvironmental stimuli, macrophages are polarized into two populations, M1 macrophages which are classically activated by interferon (IFN)-γ with lipopolysaccharides ...(LPSs) and M2 macrophages which are alternatively activated by interleukin-4 (IL-4), to perform specific roles in innate immune responses. Accordingly, macrophages occupy distinct metabolic profiles, regulated by orchestrated factors and signaling pathways, including the PI3K-AKT, HIF, c-Myc, AMPK, and PPARs pathways. These factors and pathways play pivotal roles not only in metabolic regulation but also in macrophage polarization. After activation, classically activated M1 macrophages and alternatively activated M2 macrophages display distinct patterns in glucose, lipid, amino acid and iron metabolism. Here, we summarized recently discovered metabolism-related inflammatory signaling factors, along with reprogrammed metabolism, after the activation of macrophages under conditions related to immunity and cancer. Additionally, macrophage regulatory roles in infectious diseases, cancer progression and anti-cancer immunotherapy are discussed in terms of metabolic profiles, providing insight into the prevention and treatment of immune-associated diseases.
•Recent studies about macrophages metabolism in inflammations.•Recent studies about macrophages metabolism in cancer progression.•Recent study progresses about macrophages metabolism in anti-cancer immunotherapy.•Research prospect about macrophage metabolism profile in inflammation.
The use of formic acid (FA) to produce molecular H2 is a promising means of efficient energy storage in a fuel‐cell‐based hydrogen economy. To date, there has been a lack of heterogeneous catalyst ...systems that are sufficiently active, selective, and stable for clean H2 production by FA decomposition at room temperature. For the first time, we report that flexible pyridinic‐N‐doped carbon hybrids as support materials can significantly boost the efficiency of palladium nanoparticle for H2 generation; this is due to prominent surface electronic modulation. Under mild conditions, the optimized engineered Pd/CN0.25 catalyst exhibited high performance in both FA dehydrogenation (achieving almost full conversion, and a turnover frequency of 5530 h−1 at 25 °C) and the reversible process of CO2 hydrogenation into FA. This system can lead to a full carbon‐neutral energy cycle.
Pyridinic‐N‐tuned catalysis: An electron‐rich pyridinic‐N dopant modulates the electronic interactions between the active sites of palladium nanoparticles and the carbon support. Formic acid dehydrogenation at room temperature is significantly boosted by the pyridinic‐N‐doped palladium catalyst, presenting an efficient and reliable route to clean H2 generation and sustainable energy storage.
Energy is the largest overhead cost in the production of agricultural greenhouse crops in temperate climates. Moreover, the initial cost of fossil fuels and traditional energy are dramatically ...increasing. The negative environmental impacts, limited sources of fossil fuels and a high consumption of energy and food have caused the increase in demand for solar energy as a green and sustainable choice. Therefore, this paper reviews the solar energy application technologies in the environmental control systems of greenhouses (cooling, heating and lighting) mainly the generated energy of photovoltaic (PV) and solar collectors, as well as the PV water pumping for irrigation. Furthermore, this paper briefly discusses the economic analyses and the challenges for this technology.
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