The present study aimed to examine the effectiveness of an individualized training program based on force‐velocity (FV) profiling on jumping, sprinting, strength, and power in athletes. Forty ...national level team sport athletes (20 ± 4years, 83 ± 13 kg) from ice‐hockey, handball, and soccer completed a 10‐week training intervention. A theoretical optimal squat jump (SJ)‐FV‐profile was calculated from SJ with five different loads (0, 20, 40, 60, and 80 kg). Based on their initial FV‐profile, athletes were randomized to train toward, away, or irrespective (balanced training) of their initial theoretical optimal FV‐profile. The training content was matched between groups in terms of set x repetitions but varied in relative loading to target the different aspects of the FV‐profile. The athletes performed 10 and 30 m sprints, SJ and countermovement jump (CMJ), 1 repetition maximum (1RM) squat, and a leg‐press power test before and after the intervention. There were no significant group differences for any of the performance measures. Trivial to small changes in 1RM squat (2.9%, 4.6%, and 6.5%), 10 m sprint time (1.0%, −0.9%, and −1.7%), 30 m sprint time (0.9%, −0.6%, and −0.4%), CMJ height (4.3%, 3.1%, and 5.7%), SJ height (4.8%, 3.7%, and 5.7%), and leg‐press power (6.7%, 4.2%, and 2.9%) were observed in the groups training toward, away, or irrespective of their initial theoretical optimal FV‐profile, respectively. Changes toward the optimal SJ‐FV‐profile were negatively correlated with changes in SJ height (r = −0.49, p < 0.001). Changes in SJ‐power were positively related to changes in SJ‐height (r = 0.88, p < 0.001) and CMJ‐height (r = 0.32, p = 0.044), but unrelated to changes in 10 m (r = −0.02, p = 0.921) and 30 m sprint time (r = −0.01, p = 0.974). The results from this study do not support the efficacy of individualized training based on SJ‐FV profiling.
Glucocorticoids (GC) are a controversial yet commonly used intervention in the clinical management of acute inflammatory conditions, including sepsis or traumatic injury. In the context of major ...trauma such as surgery, concerns have been raised regarding adverse effects from GC, thereby necessitating a better understanding of how GCs modulate the immune response. Here we report the results of a randomized controlled trial (NCT02542592) in which we employ a high-dimensional mass cytometry approach to characterize innate and adaptive cell signaling dynamics after a major surgery (primary outcome) in patients treated with placebo or methylprednisolone (MP). A robust, unsupervised bootstrap clustering of immune cell subsets coupled with random forest analysis shows profound (AUC = 0.92, p-value = 3.16E-8) MP-induced alterations of immune cell signaling trajectories, particularly in the adaptive compartments. By contrast, key innate signaling responses previously associated with pain and functional recovery after surgery, including STAT3 and CREB phosphorylation, are not affected by MP. These results imply cell-specific and pathway-specific effects of GCs, and also prompt future studies to examine GCs' effects on clinical outcomes likely dependent on functional adaptive immune responses.
Magnetic resonance spectroscopy (MRS)-a method of analysing metabolites in vivo-has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field ...strengths, MRS provides an improved signal-to-noise-ratio and spectral resolution, but 7T studies on patients with gliomas are sparse. The purpose of this exploratory study was to evaluate the potential clinical implication of the use of single-voxel MRS at 7T to assess metabolic information on lesions in a pilot cohort of patients with grade II and III gliomas.
We scanned seven patients and seven healthy controls using the semi-localization by adiabatic-selective refocusing sequence on a Philips Achieva 7T system with a standard dual-transmit head coil. The metabolic ratios were calculated relative to water and total creatine. Additionally, 2-hydroxyglutarate (2-HG) MRS was carried out in four of the patients, and the 2-HG concentration was calculated relative to water.
When comparing the tumour data to control regions in both patients and healthy controls, we found that the choline/creatine and myo-inositol/creatine ratios were significantly increased and that the N-acetylaspartate/creatine and the neurotransmitter glutamate/creatine ratios were significantly decreased. The N-acetylaspartate/water and glutamate/water ratios were also significantly decreased. The lactate/water and lactate/creatine ratios showed increases, although not significant. The GABA/water ratio was significantly decreased, but the GABA/creatine ratio was not. MRS spectra showed the presence of 2-HG in three of the four patients studied. Three of the patients, including the MRS 2-HG-negative patient, were operated on, and all of them had the IDH mutation.
Our findings were consistent with the existing literature on 3T and 7T MRS.
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