•Exploitative and exploratory innovations are embedded in double networks.•A knowledge network is constituted by coupling among knowledge elements.•Knowledge and collaboration networks are decoupled ...and have different integrations.•Knowledge and collaboration networks influence innovation in diverse ways.
Innovations of organizations are doubly embedded in knowledge networks constituted by coupling among knowledge elements and in social networks formed by collaborative relationships among organizations. This study explores the structural properties of such relationships and their possible influences on organizational innovations in terms of exploitation and exploration in the emerging nano-energy field. Results indicate that the knowledge networks and the technology-based collaboration networks in the nano-energy field are decoupled and that they have different degrees of integration. Some structural features of knowledge and collaboration networks influence organizations’ exploitative and exploratory innovations in diverse ways. Firstly, direct ties of an organization's knowledge elements in a knowledge network have an inverted U-shaped effect on its exploitative innovation, which is not the case in exploratory innovation. Direct ties in a collaboration network have an inverted U-shaped effect on both its exploitative and exploratory innovations. Secondly, indirect ties of an organization's knowledge elements in a knowledge network affect its exploitative innovation, but not its exploratory innovation. However, indirect ties in a collaboration network affect exploratory innovation, but not exploitative innovation. Thirdly, non-redundancy among ties in a knowledge network exhibits the opposite effect, hindering exploitative innovation, but favoring exploratory innovation. By contrast, non-redundancy among ties in a collaboration network favors exploitative innovation, but shows a non-significant effect on exploratory innovation.
This study explores the intercultural activities in teaching Mandarin to international students in China. A sample of five Mandarin teachers with rich experience in teaching international students ...within Chinese universities. Data were collected through classroom observation, teachers’ interviews and reflective journals and analyzed through thematic analysis using the framework of Byram’s notion of intercultural competence in language teaching and learning. The results show that intercultural activities can effectively promote Mandarin teaching for international students. The findings also suggest Mandarin teachers can provide more opportunities for international students to share their values and opinions and adopt more activities to teach cultural knowledge. Accordingly, recommendations on preparing intercultural competence are concluded and put forward, which might support future teaching.
Plasmonic colour printing based on engineered metasurfaces has revolutionized colour display science due to its unprecedented subwavelength resolution and high-density optical data storage. However, ...advanced plasmonic displays with novel functionalities including dynamic multicolour printing, animations, and highly secure encryption have remained in their infancy. Here we demonstrate a dynamic plasmonic colour display technique that enables all the aforementioned functionalities using catalytic magnesium metasurfaces. Controlled hydrogenation and dehydrogenation of the constituent magnesium nanoparticles, which serve as dynamic pixels, allow for plasmonic colour printing, tuning, erasing and restoration of colour. Different dynamic pixels feature distinct colour transformation kinetics, enabling plasmonic animations. Through smart material processing, information encoded on selected pixels, which are indiscernible to both optical and scanning electron microscopies, can only be read out using hydrogen as a decoding key, suggesting a new generation of information encryption and anti-counterfeiting applications.
Owing to the increasing application of engineered nanoparticles (NPs), besides the workplace, human beings are also exposed to NPs from nanoproducts through the skin, respiratory tract, digestive ...tract and vein injection. This review states pathways of cellular uptake, subcellular distribution and excretion of NPs. The uptake pathways commonly include phagocytosis, micropinocytosis, clathrin‐ and caveolae‐mediated endocytosis, scavenger receptor‐related pathway, clathrin‐ or caveolae‐independent pathway, and direct penetration or insertion. Then the ability of NPs to decrease cell viability and metabolic activity, change cell morphology, and destroy cell membrane, cytoskeleton and cell function was presented. In addition, the lowest dose decreasing cell metabolic viability compared with the control or IC50 of silver, titanium dioxide, zinc oxide, carbon black, carbon nanotubes, silica, silicon NPs and cadmium telluride quantum dots to some cell lines was gathered. Next, this review attempts to increase our understanding of NP‐caused adverse effects on organelles, which have implications in mitochondrial dysfunction, endoplasmic reticulum stress and lysosomal rupture. In particular, the disturbance of mitochondrial biogenesis and mitochondrial dynamic fusion‐fission, mitophagy and cytochrome c‐dependent apoptosis are involved. In addition, prolonged endoplasmic reticulum stress will result in apoptosis. Rupture of the lysosomal membrane was associated with inflammation, and both induction of autophagy and blockade of autophagic flow can result in cytotoxicity. Finally, the network mechanism of the combined action of multiple organelle dysfunction, apoptosis, autophagy and oxidative stress was discussed.
This review attempted to summarize the uptake and excretion pathway of nanoparticles, nanoparticle‐induced cytotoxicity: decrease in cell viability and metabolic activity, morphological change, destruction of cell membrane, cytoskeleton and function, and disturbance of organelles. Furthermore, the mechanism of cytotoxicity, with respect to the crosstalk among mitochondrial dysfunction, endoplasmic reticulum stress, lysosomal rupture, autophagy, apoptosis, inflammation and increase of reactive oxygen species, has been discussed.
Abstract
Light projection displays play an increasingly important role in our modern life. Core projection systems including liquid crystal displays and digital micromirror devices can impose spatial ...light modulation and actively shape light waves. Recently, the advent of metasurfaces has revolutionized design concepts in nanophotonics, enabling a new family of optical elements with exceptional degrees of freedom. Here, we demonstrate a light projection display technology based on optical metasurfaces, called digital metasurface device (DMSD). Each metasurface pixel in a DMSD is electrically reconfigurable with well-controlled programmability and addressability. The DMSD can not only continuously modulate the intensity of light with high contrast, but also shape the wavefront of light generated by each metasurface pixel and dynamically switch between arbitrary holographic patterns. Our approach will pave an avenue towards the development of customized light projection devices. It will also drive the field of dynamic optical metasurfaces with fresh momentum and inspiring concepts.
When applying secondary analysis on published survival data, it is critical to obtain each patient's raw data, because the individual patient data (IPD) approach has been considered as the gold ...standard of data analysis. However, researchers often lack access to IPD. We aim to propose a straightforward and robust approach to obtain IPD from published survival curves with a user-friendly software platform.
Improving upon existing methods, we propose an easy-to-use, two-stage approach to reconstruct IPD from published Kaplan-Meier (K-M) curves. Stage 1 extracts raw data coordinates and Stage 2 reconstructs IPD using the proposed method. To facilitate the use of the proposed method, we developed the R package IPDfromKM and an accompanying web-based Shiny application. Both the R package and Shiny application have an "all-in-one" feature such that users can use them to extract raw data coordinates from published K-M curves, reconstruct IPD from the extracted data coordinates, visualize the reconstructed IPD, assess the accuracy of the reconstruction, and perform secondary analysis on the basis of the reconstructed IPD. We illustrate the use of the R package and the Shiny application with K-M curves from published studies. Extensive simulations and real-world data applications demonstrate that the proposed method has high accuracy and great reliability in estimating the number of events, number of patients at risk, survival probabilities, median survival times, and hazard ratios.
IPDfromKM has great flexibility and accuracy to reconstruct IPD from published K-M curves with different shapes. We believe that the R package and the Shiny application will greatly facilitate the potential use of quality IPD and advance the use of secondary data to facilitate informed decision making in medical research.
Coupling Effects in Optical Metamaterials Liu, Na; Giessen, Harald
Angewandte Chemie (International ed.),
December 17, 2010, Letnik:
49, Številka:
51
Journal Article
Recenzirano
Metamaterials have become one of the hottest fields of photonics since the pioneering work of John Pendry on negative refractive index, invisibility cloaking, and perfect lensing. Three‐dimensional ...metamaterials are required for practical applications. In these materials, coupling effects between individual constituents play a dominant role for the optical and electronic properties. Metamaterials can show both electric and magnetic responses at optical frequencies. Thus, electric as well as magnetic dipolar and higher‐order multipolar coupling is the essential mechanism. Depending on the structural composition, both longitudinal and transverse coupling occur. The intricate interplay between different coupling effects in a plasmon hybridization picture provides a useful tool to intuitively understand the evolution from molecule‐like states to solid‐state‐like bands.
A negative refractive index is an example of the fascinating properties that are unattainable in naturally occurring materials but can be engineered into artificially structured metamaterials. This Review gives an overview of the coupling principles and highlights the coupling effects in simple to complex optical metamaterials. The picture shows a four‐layer stacked split‐ring resonator metamaterial prepared by a layer‐by‐layer nanotechnique.
The somatic rhythmic teaching method has unique advantages in improving the quality of music and dance teaching. With the purpose of exploring its role in inspiring students’ creative thinking, this ...paper takes the junior high school students of X Middle School as the research object, firstly, through the questionnaire survey to understand the application of the somatic rhythmic teaching method in music and dance courses, and based on the current situation survey, we designed the somatic rhythmic classroom teaching method in music and dance teaching. Then, the control class and experimental class were selected to conduct the teaching experiment, comparing the students’ creative thinking ability and learning achievement before and after the experiment. After the practice of Somatic Rhythmic Teaching, the performance of students in the experimental class is 36.17% higher than that of the control class, and there is a significant difference between the two classes in the four dimensions of creative thinking (P<0.001), which makes Somatic Rhythmic Teaching enlightening to students’ creative thinking.
In this paper, by analyzing the four American vocal singing styles, the vocal semantics beyond the semantics of the four vocal singing styles are constructed by using the common knowledge map, and ...the heavy semantic fusion mechanism is established based on the pre-training model of the knowledge map to obtain the contextual semantic features, and the relational classification model MSF-RC is realized. To predict the degree of fusion of the three vocal singing styles, the classical gray theory and To predict the degree of fusion of the three vocal singing styles, the Markov chain prediction is completed for the residual numerical sequences with large volatility. After testing, the accuracy of this algorithm is 0.88, the recall is 0.92, the F-Score is 0.88, and the MAPE value between the actual values of American singing and ethnic singing fusion and the prediction results corrected by the fusion Markov chain model is 1%, which has high prediction accuracy.
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