Background
Atopic dermatitis (AD), psoriasis and senile xerosis comprise common chronic and relapsing inflammatory skin disorders with clinical symptoms such as lichenification, pruritus and ...inflammatory lesions that affect the quality of life of patients.
Objectives
In this study, we aimed to evaluate the efficacy of a novel “emollient plus” formulation (Lipikar baume AP+M), containing non-living lysates of non-pathogenic
Vitreoscilla Filiformis
bacteria from LaRoche-Posay Thermal Spring water, in improving quality of life, alleviating skin pain, and managing symptoms of mild-to-severe AD or skin disorders associated with dryness or severe xerosis in adults.
Materials & Methods
The study included 1,399 adult patients, who participated in a two-month observational study over two visits, conducted at dermatologists’ practices. Visits included clinical assessment of skin disease before and after administration of the product as well as completion of the 10-question Dermatology Life Quality Index. Questionnaires were used to evaluate efficacy, safety, satisfaction and tolerance of the product both by the dermatologists and patients, as well as assess quality of life of patients.
Results
Statistically significant improvement (
p
<0.001) by at least one grade was observed by more than 90% based on patients’ evaluation of efficacy regarding intensity of the skin disease, skin dryness, surface affected by inflammatory lesions, pruritus, quality of sleep, daily discomfort, dryness and desquamation. Quality of life after two months improved by 82.6%.
Conclusion
This study demonstrated significant reduction in symptoms of mild-to-severe skin dryness after application of the “emollient plus” formulation over two months, either alone or as adjunctive therapy.
