The strength of adhesion of a reinforcing element to cement stone during anchor-pile installation, and its dependence on the composition of the cement grout and the surface condition of the ...reinforcing tube is examined.
This article presents the results of the development of structural-analytical mesomechanics based on the concept of interacting multi-level (micro, meso and macro) plastic flow, the evolution of ...structural damage and martensitic phase transformations. It presents a system of constitutive relations, which take into account the mutual influence of plastic deformations, processes of destruction and structural phase transformations of martensitic nature for alloys with shape memory effect (SME).
The Cosmic Ray Energetics And Mass (CREAM) instrument Ahn, H.S.; Allison, P.; Bagliesi, M.G. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
09/2007, Letnik:
579, Številka:
3
Journal Article
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The Cosmic Ray Energetics And Mass (CREAM) experiment is designed to investigate high-energy (10
12∼10
15
eV) cosmic rays over the elemental range from hydrogen to iron (1⩽
Z⩽26), through a series of ...long balloon flights. Originally planned to be flown on the first of the new Ultra Long Duration Balloons (ULDB) being developed by NASA, the CREAM instrument was launched as a Long Duration Balloon (LDB) payload from McMurdo Station, Antarctica on December 16, 2004 and flew for a record-breaking 42 days. A second CREAM flight one year later lasted 28 days. The CREAM design is unique in that it obtains two independent energy measurements using a tungsten/scintillator sampling calorimeter and a Transition Radiation Detector (TRD) with up to four independent charge measurements of incident particles using a novel Timing-based scintillator Charge Detector (TCD), a plastic Cherenkov Detector (CD), scintillating fiber hodoscopes, and a Silicon Charge Detector (SCD). The energy limits are determined by trigger efficiency and telemetry bandwidth at the low end and by statistics at the high end.
Summary
Aspirin, dipyridamole, cilostazol, thienopyridines and glycoprotein IIb/IIIa inhibitors represent the classical examples of the established antiplatelet agents commonly used for the secondary ...prevention in patients after vascular events. Obviously, the era of expanding antiplatelet regimens and indications may require new agents as the substitutes, or additions to the available strategies. However, recent results of the majority of antiplatelet trials strongly suggest boarder line advantages in clinical outcomes, and higher associated bleeding risks with the novel antiplatelet agents or/and regimens. Moreover, unexpected failures, such as lack of efficacy of clopidogrel and aspirin combination for ischaemic stroke prevention (MATCH), or use of the same antiplatelet regimen for the primary vascular prevention (CHARISMA) raise legitimate concerns that the concept ‘the more the better’ may not be valid. Broad use of statins, angiotensin receptor blockers and selective serotonin reuptake inhibitors may be in part responsible for the lack of impressive results with the antiplatelet therapy because each of these drug classes per se inhibits platelets. In this review, we discuss the available evidence and potential clinical significance of these findings.
Introduction.
This article discusses the problem of developing the creative potential of a teacher. The theoretical and methodological approaches to this problem are analyzed. The theoretical basis ...of the study was the work of the idea of innovative activity as a factor in the development of the school and the general education system as a whole (V.N. Averkin, A.G. Kasprzhak, N.M. Martynova, N.A. Sadovsky and others); general issues of innovation (V.A. Bolotov, V.I. Zagvyazinsky, A.G. Kasprzhak, M.V. Klarin, V.A. Slastenin, etc.); ideas of pedagogical innovation and the role of the teacher in the development of innovative processes (Yu.K. Babansky, V.I. Zagvyazinsky, G.A. Ignatiev, A.P. Tryapitsyna, A.V. Khutorskoy, etc.).As a result of the study, it was found that one of the leading tasks in the development of the lifelong education system is the orientation of educational programs towards teaching the skills necessary for innovative activity, including analytical and critical thinking, the pursuit of new things, the ability to constantly learn, readiness for reasonable risk, creativity and enterprise, willingness to work in a highly competitive environment. At the same time, the practice teacher must be psychologically prepared for pedagogical activity in the new sociocultural conditions, make original non-standard decisions, plan the educational process and predict possible results, be prepared for innovative activities. One of the possible ways of professional development of a teacher-practitioner is his participation in federal innovation platforms. Under the conditions of the federal innovation platform, the development of the scientific and innovative potential of educational organizations, the introduction of innovative educational programs, the inclusion of students and teachers in design and research activities aimed at unlocking the creative potential of educational institutions is being updated.The work emphasizes that according to the research of modern scientists (V.Zhabina, S.N. Tolstov, etc., innovative activity is inseparable from creativity, because it provides the generation of new ideas, the implementation of which become innovations. As a result, the purpose of the study is actualized: development of the teacher’s creative potential in the context of the activities of the federal innovative platform “Pedagogical Leadership”.
Materials and methods.
A model of complex psychological and pedagogical support for professional self-determination and professional career of students is developed and presented. The model is implemented on the basis of the Municipal Public Educational Institution “School No. 187 with in-depth study of individual subjects” in the city of Novgorod. The school carries out general education programs (the normative period of study is 2 years); general educational programs with an in-depth study of the economy (standard training period of 2 years); general educational programs with in-depth study of mathematics (the normative period of study is 2 years).In order to determine the initial features of professional self-determination of high school students, a pilot study was conducted. The diagnostic tools are based on the following methods: the questionnaire of personal orientations of E. Shostroma, adapted by Yu.E. Aleshina, L.Ya. Gozman, M.V. Zagika – measures the self-actualization of the personality (CAT); methods of studying the factors of attractiveness of the profession (V.A. Yadov, modification N.V. Kuzmina, A.A. Rean).
Results.
The purpose of the study was realized on the example of the experimental work of the MAOU “School No. 187 with in-depth study of individual subjects” (Nizhny Novgorod). Since 2019, this school has been a member of the federal innovative platform “Pedagogical Leadership”. The authors note that the innovative platform is a motivational, informative and technological resource for the professional development of the teacher. At the same time, along with pedagogical leadership, the development of creative potential is a key element in achieving the effectiveness of the school system, focused on the implementation of innovative projects.The article defines the tasks of implementing the innovative platform "Pedagogical leadership." The following directions of work are revealed: 1) organization of a project-initiative group, the main function of which is to develop a concept and model of activity of an innovation platform, determine the ways of its functioning in terms of child-adult interaction in general education; 2) the formation of a modern and safe digital educational environment, providing high quality and accessibility of general and additional education to the subjects of the educational process; 3) ensuring the professional development of the teacher in accordance with his needs and motives; 4) the development of teaching aids, programs, monographs together with university teachers; 5) the introduction of effective mechanisms for encouraging educators; 6) improving the system for assessing qualifications and the quality of the results of a teacher. The practical significance of innovative solutions in the framework of the implementation of the innovative project “Pedagogical Leadership” consists in the fact that the pedagogical community is offered specific conceptual and methodological products that ensure the formation of a new image of a leading teacher who takes an active life and professional position, has creative potential, and innovative activity skills.
Discussion and Conclusions.
Based on the results of the study, the following conclusions can be drawn. For a relatively short time of our research, we revealed positive dynamics in the studied group of teachers. The results obtained indicate the feasibility of the study. We also note that as a result of the activities of the federal innovative platform “Pedagogical Leadership”, it is planned to create a project office for the formation of pedagogical leadership in continuing education.
Clinical depression has been identified as an independent risk factor for increased mortality in patients with coronary artery disease. Enhanced platelet activity has been suggested as the mechanism ...responsible for this adverse association. Selective serotonin reuptake inhibitors (SSRIs) are known to inhibit platelets in patients undergoing coronary stenting. We sought to determine whether concomitant therapy with SSRIs would yield additional anti‐platelet benefit in patients with congestive heart failure (CHF) already treated with antecedent aspirin. A total of 88 patients with left ventricular ejection fraction (LVEF) <40% or CHF symptoms in the setting of preserved systolic function and NYHA Class II–IV were analyzed. Of these, 23 patients (26%) were chronic SSRI users (SSRI+), and 65 patients were free from SSRI therapy (SSRI−). All patients received aspirin (325 mg) for at least 1 month prior to platelet studies. Platelets were assessed by aggregometry, flow cytometry and a rapid analyzer. The SSRI+ group exhibited a substantial decrease in platelet activity when compared with SSRI− patients, as manifested by a significant reduction in ADP‐ (P=0.001), and collagen‐induced (P=0.02) aggregation, and the expression of PECAM‐1 (P=0.03), GPIb (P=0.03), GP IIb/IIIa antigen (P=0.02) and GP IIb/IIIa activity with PAC‐1 antibody (P=0.04) and P‐selectin (P=0.02). Therapy with SSRIs also resulted in the reduced formation of platelet–leukocyte microparticles (P=0.01). Epinephrine‐induced aggregation in plasma, collagen‐induced whole blood aggregation, closure time and expression of vitronectin receptor, CD63, CD107a, CD107b and CD151 did not differ between groups. In patients with CHF already on aspirin, SSRI therapy was associated with further inhibition of platelet function. This observation may help to explain some of the clinical benefits associated with SSRI therapy. Further clinical trials may help to elucidate the potential outcome benefits of SSRIs in other potential thrombotic circumstances.
Summary
Therapy with aspirin and/or adenosine diphosphate (ADP) receptor blockers is associated with better outcomes via inhibition of platelet activity, and subsequent reduction of ischemic vascular ...events. Non‐compliance (NC) is a well‐recognised hazard limiting the clinical utility of antiplatelet agents, and, probably worsening outcomes. However, comprehensive platelet characteristics of a confirmed NC patient after acute vascular event have never been reported within a major randomised trial with ADP‐receptor antagonists. A 48‐year‐old male patient, well‐educated, was among patients enrolled in the platelet sub‐study for the JUMBO trial. He received 325 mg of aspirin daily for 9 months, presented with unstable angina for urgent coronary intervention, and was successfully reperfused with two intracoronary stents. The patient was randomised to a 60 mg prasugrel loading dose, and 10 mg of prasugrel daily for 30 days. Platelets were assessed at baseline, 4 and 24 h, and at 30 days after acute coronary event utilising ADP‐, and collagen‐induced conventional aggregometry, rapid cartridge‐based analyser and flow cytometry. Loading with prasugrel resulted in significant inhibition of platelet activity during and after stenting. However, after assessing platelet biomarkers at 30 days, voluntary withdrawal from the antiplatelet agents was suspected. Based on the platelet activity characteristics, NC was later confirmed, and the patient admitted that he stopped taking both prasugrel and aspirin shortly after discharge due to minor bleeding episodes after shaving. Major platelet activity biomarkers of the index NC patient were compared with those from compliant prasugrel‐, clopidogrel‐treated patients, and healthy controls. The platelet tests uniformly revealed rebound activation by all platelet measures (at least twofold increase) while being especially high for ADP‐, and collagen‐induced aggregation, platelet/endothelial cell adhesion molecule‐1 (PECAM‐1), glycoprotein (GP)Ib, GPIIb/IIIa activity, P‐selectin, protease activated receptor (PAR)‐1 thrombin receptor (activated and intact epitopes), and thrombospondin expression. The clinical benefits of antiplatelet agents are not only denied in NC outpatients, but may put them at additional risk for worsened vascular outcomes due to the rebound platelet activation. Proclaimed ‘resistance’ to antiplatelet agents may at least in part be a result of NC, especially in the chronic uncontrolled setting. Enforcing compliance will improve outcomes in the clinical trials, and save lives of patients really receiving antiplatelet therapy.
It has been found that actin-specific bacterial protease ECP32 cleaves prokaryotic heat shock protein DnaK, which belongs to the family of heat shock proteins with molecular weight 70 kDa. We propose ...a new one-step method for DnaK purification using heat treatment. The technique yields ∼1 mg of partially purified DnaK from 25 g of wet bacterial biomass. Polyclonal antibodies against DnaK were obtained. The degree of ECP32 catalyzed proteolysis of partially purified DnaK and that of DnaK in initial cell extracts was compared.
PHOTONIC CRYSTAL WAVEGUIDE BIOSENSOR ZANISHEVSKAYA, A. A; MALININ, A. V; TUCHIN, V. V ...
Journal of innovative optical health science,
04/2013, Letnik:
6, Številka:
2
Journal Article
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The hollow core photonic crystal waveguide biosensor is designed and described. The biosensor was tested in experiments for artificial sweetener identification in drinks. The photonic crystal ...waveguide biosensor has a high sensitivity to the optical properties of liquids filling up the hollow core. The compactness, good integration ability to different optical systems and compatibility for use in industrial settings make such biosensor very promising for various biomedical applications.
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