Diabetes mellitus is a common problem with high levels of morbidity and mortality. Economic costs of treating the disease and its complications are very high. Diabetic complications arise with ...chronic hyperglycaemia in the case of hypoglycemia. Prevention of these conditions contributes to the maintenance of normoglycemia, what a crucial role it plays an adequate self-control. Precise instruments for measuring blood glucose at home with minimal errors make it possible to take measures to achieve a compensation of the disease, thereby preventing the occurrence of acute and late complications, improving the quality and duration of life for the patient and reducing the cost of its treatment.
Natural gas conversion is a complex dynamic process in need of constant monitoring. Improvement and automation of its steps is of great importance for upgrading quality and reducing cost. Conversion ...optimisation requires application of modern analytical instrumentation. Current analytical technics are time consuming, lack versatility and hardly prone to automation. In this work, development of comprehensive analytical procedure for control of triglycol contaminants accumulating during gas drying step is discussed. This procedure is based on LC-MS/MS, GCMS and multiparametric statistical analysis. The analytical procedure presented in this work is rapid and allows determining a wide range of triglycol contaminants.
A series of new betulinic and ursolic acid conjugates with a lipophilic triphenylphosphonium cation, meant to enhance the bioavailability and mitochondriotropic action of natural triterpenes, have ...been synthesized. The
experiments on three human cancer cell lines (MCF-7, HCT-116 and TET21N) revealed that all the obtained triphenylphosphonium triterpene acid derivatives not only showed higher cytotoxicity as compared to betulinic acid but were also markedly superior in triggering mitochondria-dependent apoptosis, as assessed using a range of apoptosis markers such as cytochrome
release, stimulation of caspase-3 activity, and cleavage of poly(ADP-ribose) polymerase, which is one of the targets of caspase 3. The IC
was much lower for all triphenylphosphonium derivatives when compared to betulinic acid. Out of the tested group of conjugates, the most potent toxicity was exhibited by the betulinic acid conjugate
(for
, the IC
values against MCF-7 and TET21N cells were 0.70 μM and 0.74 μM; for betulinic acid (BA), IC
> 25 μM against MCF-7 cells).
The author presents his own clinical case demonstrating the long stage and difficulties in diagnosing a rare tumor of the Ewing’s Family of Sarcomas in a young patient, due to the peculiarity of the ...course of the disease, manifested by a non-pathognomonic clinical pattern.
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