Ferroelectric polarization and metallic conduction are two seemingly irreconcilable properties that cannot normally coexist in a single system, as the latter tends to screen the former. Polar metals, ...however, defy this rule and have thus attracted considerable attention as a new class of ferroelectrics exhibiting novel properties. Here, we fabricate a new polar metal film based on the typical ferroelectric material BaTiO3by combining chemical doping and epitaxial strain induced by a substrate. The temperature dependences of the c-axis lattice constant and the second harmonic generation intensity of La-doped BaTiO3films indicate the existence of polar transitions. In addition, through La doping, films become metallic at the polar phase, and metallicity enhancement at the polar state occurs in low-La-doped films. This intriguing behaviour is effectively explained by our first-principles calculations. Our demonstration suggests that the carrier doping to ferroelectric material with epitaxial strain serves as a new way to explore polar metals.
Abstract
A new High-Temperature Superconducting ECR (HTS-ECR) ion source is under development in Research Center for Nuclear Physics (RCNP), Osaka University. This ion source will be used for ...production of high intensity proton, deuteron and He ion beams. The HTS-ECR magnets are composed of three solenoid coils and a set of sextupole coils made of REBCO tapes, a high-temperature superconductor. The HTS-ECR ion source is designed to operate at frequency of 2.45 GHz and 10 GHz. Performance test of the HTS coils had been carried out at 31 K and 77 K. This HTS coil technology will be applied to development of a meter-size HTS coil system of a high intensity compact AVF cyclotron. This paper introduces the basic design of the HTS-ECR ion source. The performance test results showed that REBCO solenoids remain superconducting state with a current up to 400 A. Simulation results of the magnetic field and electromagnetic field distributions in a plasma chamber fulfilled the requirements of electron cyclotron resonance conditions at 2.45 GHz and 10 GHz. Simulation result of mirror ratios and electromagnetic field amplitudes are also presented in this paper.
This study examines the relationship between paternal height or body mass index (BMI) and birth weight of their offspring in a Japanese general population. The sample included 33,448 pregnant ...Japanese women and used fixed data, including maternal, paternal and infant characteristics, from the Japan Environment and Children’s Study (JECS), an ongoing nationwide birth cohort study. Relationships between paternal height or BMI and infant birth weight i.e., small for gestational age (SGA) and large for gestational age (LGA) were examined using a multinomial logistic regression model. Since fetal programming may be a sex-specific process, male and female infants were analyzed separately. Multivariate analysis showed that the higher the paternal height, the higher the odds of LGA and the lower the odds of SGA in both male and female infants. The effects of paternal BMI on the odds of both SGA and LGA in male infants were similar to those of paternal height; however, paternal height had a stronger impact than BMI on the odds of male LGA. In addition, paternal BMI showed no association with the odds of SGA and only a weak association with the odds of LGA in female infants. This cohort study showed that paternal height was associated with birth weight of their offspring and had stronger effects than paternal BMI, suggesting that the impact of paternal height on infant birth weight could be explained by genetic factors. The sex-dependent effect of paternal BMI on infant birth weight may be due to epigenetic effects.
Global 'second-generation' microlensing surveys aim to discover and characterize extrasolar planets and their frequency, by means of round-the-clock high-cadence monitoring of a large area of the ...Galactic bulge, in a controlled experiment. We report the discovery of a giant planet in microlensing event MOA-2011-BLG-322. This moderate-magnification event, which displays a clear anomaly induced by a second lensing mass, was inside the footprint of our second-generation microlensing survey, involving MOA, OGLE and the Wise Observatory. The event was observed by the survey groups, without prompting alerts that could have led to dedicated follow-up observations. Fitting a microlensing model to the data, we find that the time-scale of the event was t
E = 23.2 ± 0.8 d, and the mass ratio between the lens star and its companion is q = 0.028 ± 0.001. Finite-source effects are marginally detected, and upper limits on them help break some of the degeneracy in the system parameters. Using a Bayesian analysis that incorporates a Galactic structure model, we estimate the mass of the lens at
, at a distance of 7.56 ± 0.91 kpc. Thus, the companion is likely a planet of mass
, at a projected separation of
au, rather far beyond the snow line. This is the first pure-survey planet reported from a second-generation microlensing survey, and shows that survey data alone can be sufficient to characterize a planetary model. With the detection of additional survey-only planets, we will be able to constrain the frequency of extrasolar planets near their systems' snow lines.
We searched for solar neutrons using the data collected by six detectors from the International Network of Solar Neutron Telescopes and one Neutron Monitor between January 2010 and December 2014. We ...considered the peak time of the X-ray intensity of thirty five ≥ X1.0 class flares detected by GOES satellite as the most probable production time of solar neutrons. We prepared a light-curve of the solar neutron telescopes and the neutron monitor for each flare, spanning ± 3 h from the peak time of GOES. Based on these light curves, we performed a statistical analysis for each flare. Setting a significance level at greater than 3σ, we report that no statistically significant signals due to solar neutrons were found. Therefore, upper limits are determined by the background level and solar angle of these thirty five solar flares. Our calculation assumed a power-law neutron energy spectrum and an impulsive emission profile at the Sun. The estimated upper limits of the neutron emission are consistent within the order of magnitude of the successful detections of solar neutrons made in solar cycle 23.
Summary
Azoospermia affects up to 1% of adult men. Non‐obstructive azoospermia is a multifactorial disorder whose molecular basis remains largely unknown. To date, mutations in several genes and ...multiple submicroscopic copy‐number variations (CNVs) have been identified in patients with non‐obstructive azoospermia. The aim of this study was to clarify the contribution of nucleotide substitutions in known causative genes and submicroscopic CNVs in the genome to the development of non‐obstructive azoospermia. To this end, we conducted sequence analysis of 25 known disease‐associated genes using next‐generation sequencing and genome‐wide copy‐number analysis using array‐based comparative genomic hybridization. We studied 40 Japanese patients with idiopathic non‐obstructive azoospermia. Functional significance of molecular alterations was assessed by in silico analyses. As a result, we identified four putative pathogenic mutations, four rare polymorphisms possibly associated with disease risk, and four probable neutral variants in 10 patients. These sequence alterations included a heterozygous splice site mutation in SOHLH1 and a hemizygous missense substitution in TEX11, which have been reported as causes of non‐obstructive azoospermia. Copy‐number analysis detected five X chromosomal or autosomal CNVs of unknown clinical significance, in addition to one known pathogenic Y chromosomal microduplication. Five patients carried multiple molecular alterations. The results indicate that monogenic and oligogenic mutations, including those in SOHLH1 and TEX11, account for more than 10% of cases of idiopathic non‐obstructive azoospermia. Furthermore, this study suggests possible contributions of substitutions in various genes as well as submicroscopic CNVs on the X chromosome and autosomes to non‐obstructive azoospermia, which require further validation.
In association with a large solar flare on November 7, 2004, the solar neutron detectors located at Mt. Chacaltaya (5,250 m) in Bolivia and Mt. Sierra Negra (4,600 m) in Mexico recorded very ...interesting events. In order to explain these events, we have performed a calculation solving the equation of motion of anti-protons inside the magnetosphere. Based on these results, the Mt. Chacaltaya event may be explained by the detection of solar neutrons, while the Mt. Sierra Negra event may be explained by the first detection of very high energy solar neutron decay protons (SNDPs) around 6 GeV.
Background The therapeutic potential of using stem cells is tremendous. Mesenchymal stromal cells (MSC) have now been isolated in various tissues including bone marrow (BM), muscle, skin and adipose ...tissue. Among them, adipose tissue could be one of the most suitable cell sources for cell therapy, because of its easy accessibility, minimal morbidity and abundance of stem cells. The large numbers of stem cells in adipose tissue means that clinically relevant stem cell numbers could be extracted from the tissue, potentially eliminating the need for in vitro expansion. To utilize these characteristics of adipose tissue fully, Cytori Therapeutics Inc. has developed a closed system called Celution™ to isolate and concentrate stem cells and regenerative cells automatically from adipose tissue. Methods Adipose tissue-derived cells were isolated using the Celution™ system. The output from the Celution™ was characterized using multicolor FACS analysis with CD31, CD34, CD45, CD90, CD105 and CD146. The multidifferentiation potential of the cells was analyzed using adipogenic and osteogenic media. Results Our results showed that cells from the Celution™ are composed of heterogeneous cell populations including adipose-derived stem cells (ASC) (CD31− CD34+ CD45− CD90+ CD105− CD146− ), endothelial (progenitor) cells (CD31+ CD34+ CD45− CD90+ CD105− CD146+ ) and vascular smooth muscle cells (CD31− CD34+ CD45− CD90+ CD105− CD146+ ). We also confirmed the output contains cells able to differentiate into adipogenic and osteogenic phenotypes. Our results show that cells isolated with the Celution™ and manually are equivalent. Discussion Cells from adipose tissue can be processed by Celution™ within the time frame of a single surgical procedure. This system could provide a ‘real-time’ treatment setting that is cost-effective and safe.
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