We report the first discovery of a fast radio burst (FRB), FRB 20200125A, by the Green Bank Northern Celestial Cap (GBNCC) Pulsar Survey conducted with the Green Bank Telescope at 350 MHz. FRB ...20200125A was detected at a Galactic latitude of 58 43 with a dispersion measure of 179 pc cm3, while electron density models predict a maximum Galactic contribution of 25 pc cm3 along this line of sight. Moreover, no apparent Galactic foreground sources of ionized gas that could account for the excess DM are visible in multiwavelength surveys of this region. This argues that the source is extragalactic. The maximum redshift for the host galaxy is zmax = 0.17, corresponding to a maximum comoving distance of approximately 750 Mpc. The measured peak flux density for FRB 20200125A is 0.37 Jy, and we measure a pulse width of 3.7 ms, consistent with the distribution of FRB widths observed at higher frequencies. Based on this detection and assuming a Euclidean flux density distribution of FRBs, we calculate an all-sky rate at 350 MHz of FRBs sky−1 day−1 above a peak flux density of 0.42 Jy for an unscattered pulse having an intrinsic width of 5 ms, consistent with rates reported at higher frequencies, albeit with large uncertainties. Given the recent improvements in our single-pulse search pipeline, we also revisit the GBNCC survey sensitivity to various burst properties. Finally, we find no evidence of strong interstellar scattering in FRB 20200125A, adding to the growing evidence that some FRBs have circumburst environments where free-free absorption and scattering are not significant.
Abstract
We present timing solutions for 12 pulsars discovered in the Green Bank North Celestial Cap 350 MHz pulsar survey, including six millisecond pulsars (MSPs), a double neutron star (DNS) ...system, and a pulsar orbiting a massive white dwarf companion. Timing solutions presented here include 350 and 820 MHz Green Bank Telescope data from initial confirmation and follow-up, as well as a dedicated timing campaign spanning 1 ryr PSR J1122−3546 is an isolated MSP, PSRs J1221−0633 and J1317−0157 are MSPs in black widow systems and regularly exhibit eclipses, and PSRs J2022+2534 and J2039−3616 are MSPs that can be timed with high precision and have been included in pulsar timing array experiments seeking to detect low-frequency gravitational waves. PSRs J1221−0633 and J2039−3616 have Fermi Large Area Telescope gamma-ray counterparts and also exhibit significant gamma-ray pulsations. We measure proper motions for three of the MSPs in this sample and estimate their space velocities, which are typical compared to those of other MSPs. We have detected the advance of periastron for PSR J1018−1523 and therefore measure the total mass of the DNS system,
m
tot
= 2.3 ± 0.3
M
⊙
. Long-term pulsar timing with data spanning more than 1 yr is critical for classifying recycled pulsars, carrying out detailed astrometry studies, and shedding light on the wealth of information in these systems post-discovery.
Schizophrenia is a psychotic disorder characterized by functional dysconnectivity or abnormal integration between distant brain regions. Recent functional imaging studies have implicated large-scale ...thalamo-cortical connectivity as being disrupted in patients. However, observed connectivity differences in schizophrenia have been inconsistent between studies, with reports of hyperconnectivity and hypoconnectivity between the same brain regions. Using resting state eyes-closed functional imaging and independent component analysis on a multi-site data that included 151 schizophrenia patients and 163 age- and gender matched healthy controls, we decomposed the functional brain data into 100 components and identified 47 as functionally relevant intrinsic connectivity networks. We subsequently evaluated group differences in functional network connectivity, both in a static sense, computed as the pairwise Pearson correlations between the full network time courses (5.4 minutes in length), and a dynamic sense, computed using sliding windows (44 s in length) and k-means clustering to characterize five discrete functional connectivity states. Static connectivity analysis revealed that compared to healthy controls, patients show significantly stronger connectivity, i.e., hyperconnectivity, between the thalamus and sensory networks (auditory, motor and visual), as well as reduced connectivity (hypoconnectivity) between sensory networks from all modalities. Dynamic analysis suggests that (1), on average, schizophrenia patients spend much less time than healthy controls in states typified by strong, large-scale connectivity, and (2), that abnormal connectivity patterns are more pronounced during these connectivity states. In particular, states exhibiting cortical-subcortical antagonism (anti-correlations) and strong positive connectivity between sensory networks are those that show the group differences of thalamic hyperconnectivity and sensory hypoconnectivity. Group differences are weak or absent during other connectivity states. Dynamic analysis also revealed hypoconnectivity between the putamen and sensory networks during the same states of thalamic hyperconnectivity; notably, this finding cannot be observed in the static connectivity analysis. Finally, in post-hoc analyses we observed that the relationships between sub-cortical low frequency power and connectivity with sensory networks is altered in patients, suggesting different functional interactions between sub-cortical nuclei and sensorimotor cortex during specific connectivity states. While important differences between patients with schizophrenia and healthy controls have been identified, one should interpret the results with caution given the history of medication in patients. Taken together, our results support and expand current knowledge regarding dysconnectivity in schizophrenia, and strongly advocate the use of dynamic analyses to better account for and understand functional connectivity differences.
Abstract The Green Bank North Celestial Cap survey is one of the largest and most sensitive searches for pulsars and transient radio objects. Observations for the survey have finished; priorities ...have shifted toward long-term monitoring of its discoveries. In this study, we have developed a pipeline to handle large data sets of archival observations and connect them to recent, high-cadence observations taken using the Canadian Hydrogen Intensity Mapping Experiment telescope. This pipeline handles data for 128 pulsars and has produced measurements of spin, positional, and orbital parameters that connect data over observation gaps as large as 2000 days. We have also measured glitches in the timing residuals for five of the pulsars included and proper motion for 19 sources (13 new). We include updates to orbital parameters for 19 pulsars, including nine previously unpublished binaries. For two of these binaries, we provide updated measurements of post-Keplerian binary parameters, which result in much more precise estimates of the total masses of both systems. For PSR J0509+3801, the much improved measurement of the Einstein delay yields much improved mass measurements for the pulsar and its companion, 1.399(6) M ⊙ and 1.412(6) M ⊙ , respectively. For this system, we have also obtained a measurement of the orbital decay due to the emission of gravitational waves, P ̇ B = − 1.37 ( 7 ) × 10 − 12 , which is in agreement with the rate predicted by general relativity for these masses.
Abstract
We present timing solutions for 21 pulsars discovered in 350 MHz surveys using the Green Bank Telescope (GBT). All were discovered in the Green Bank North Celestial Cap pulsar survey, with ...the exception of PSR J0957−0619, which was found in the GBT 350 MHz Drift-scan pulsar survey. The majority of our timing observations were made with the GBT at 820 MHz. With a spin period of 37 ms and a 528 days orbit, PSR J0032+6946 joins a small group of five other mildly recycled wide binary pulsars, for which the duration of recycling through accretion is limited by the length of the companion’s giant phase. PSRs J0141+6303 and J1327+3423 are new disrupted recycled pulsars. We incorporate Arecibo observations from the NANOGrav pulsar timing array into our analysis of the latter. We also observed PSR J1327+3423 with the Long Wavelength Array, and our data suggest a frequency-dependent dispersion measure. PSR J0957−0619 was discovered as a rotating radio transient, but is a nulling pulsar at 820 MHz. PSR J1239+3239 is a new millisecond pulsar (MSP) in a 4 days orbit with a low-mass companion. Four of our pulsars already have published timing solutions, which we update in this work: the recycled wide binary PSR J0214+5222, the noneclipsing black widow PSR J0636+5128, the disrupted recycled pulsar J1434+7257, and the eclipsing binary MSP J1816+4510, which is in an 8.7 hr orbit with a redback-mass companion.
The glucocorticoid receptor (GR) is an ubiquitously expressed ligand-activated transcription factor that mediates effects of cortisol in relation to adaptation to stress. In the brain, GR affects the ...hippocampus to modulate memory processes through direct binding to glucocorticoid response elements (GREs) in the DNA. However, its effects are to a high degree cell specific, and its target genes in different cell types as well as the mechanisms conferring this specificity are largely unknown. To gain insight in hippocampal GR signaling, we characterized to which GRE GR binds in the rat hippocampus. Using a position-specific scoring matrix, we identified evolutionary-conserved putative GREs from a microarray based set of hippocampal target genes. Using chromatin immunoprecipitation, we were able to confirm GR binding to 15 out of a selection of 32 predicted sites (47%). The majority of these 15 GREs are previously undescribed and thus represent novel GREs that bind GR and therefore may be functional in the rat hippocampus. GRE nucleotide composition was not predictive for binding of GR to a GRE. A search for conserved flanking sequences that may predict GR-GRE interaction resulted in the identification of GC-box associated motifs, such as Myc-associated zinc finger protein 1, within 2 kb of GREs with GR binding in the hippocampus. This enrichment was not present around nonbinding GRE sequences nor around proven GR-binding sites from a mesenchymal stem-like cell dataset that we analyzed. GC-binding transcription factors therefore may be unique partners for DNA-bound GR and may in part explain cell-specific transcriptional regulation by glucocorticoids in the context of the hippocampus.
The Green Bank North Celestial Cap (GBNCC) pulsar survey will cover the entire northern sky (δ > −40°) at 350 MHz, and is one of the most uniform and sensitive all-sky pulsar surveys to date. We have ...created a pipeline to reanalyze GBNCC survey data to take a 350 MHz census of all pulsars detected by the survey, regardless of their discovery survey. Of the 1413 pulsars in the survey region, we were able to recover 670. For these we present measured signal-to-noise ratios (S/N), flux densities, pulse widths, profiles, and where appropriate, refined measurements of dispersion measures (DMs) (656 out of 670) and new or improved spectral indices (339 out of 670 total, 47 new, 292 improved). We also measure the period-pulse width relation at 350 MHz to scale as . Detection scans for several hundred sources were reanalyzed in order to inspect pulsars' single pulse behavior and 223 were found to exhibit evidence of nulling. With a detailed analysis of measured and expected S/N values and the evolving radio frequency interference environment at 350 MHz, we assess the GBNCC survey's sensitivity as a function of spin period, DM, and sky position. We find the sky-averaged limiting flux density of the survey to be 0.74 mJy. Combining this analysis with PsrPopPy pulsar population simulations, we predict 60/5 nonrecycled/MSP discoveries in the survey's remaining 21,000 pointings, and we begin to place constraints on population model parameters.
Abstract
The Green Bank North Celestial Cap survey is a 350 MHz all-sky survey for pulsars and fast radio transients using the Robert C. Byrd Green Bank Telescope. To date, the survey has discovered ...over 190 pulsars, including 33 millisecond pulsars and 24 rotating radio transients. Several exotic pulsars have been discovered in the survey, including PSR J1759+5036, a binary pulsar with a 176 ms spin period in an orbit with a period of 2.04 days, an eccentricity of 0.3, and a projected semi-major axis of 6.8 light seconds. Using seven years of timing data, we are able to measure one post–Keplerian parameter, advance of periastron, which has allowed us to constrain the total system mass to 2.62 ± 0.03
M
⊙
. This constraint, along with the spin period and orbital parameters, suggests that this is a double neutron star system, although we cannot entirely rule out a pulsar-white dwarf binary. This pulsar is only detectable in roughly 45% of observations, most likely due to scintillation. However, additional observations are required to determine whether there may be other contributing effects.
Background Selective serotonin reuptake inhibitors (SSRIs) effectively treat various anxiety disorders, although symptoms of anxiety are often exacerbated during early stages of treatment. We ...previously reported that acute treatment with the SSRI citalopram enhances the acquisition of auditory fear conditioning, which is consistent with the initial anxiogenic effects reported clinically. Here, we extend our findings by assessing the effects of acute SSRI treatment on the expression of previously acquired conditioned fear. Methods Rats underwent fear conditioning drug-free. Tone-evoked fear responses were tested after drug treatment the following day. This protocol more closely resembles the clinical setting than pre-conditioning treatment, because it evaluates effects of treatment on a pre-existing fear rather than on the formation of a new fear memory. Results A single pre-testing injection of the SSRIs citalopram or fluoxetine significantly increased fear expression. There was no effect of the antidepressant tianeptine or the norepinephrine reuptake inhibitor tomoxetine, indicating that this effect is specific to SSRIs. The SSRI-induced enhancement in fear expression was not blocked by tropisetron, a 5-HT3 receptor antagonist, but was blocked by SB 242084, a specific 5-HT2C receptor antagonist. Conclusions Enhanced activation of 5-HT2C receptors might be a mechanism for the anxiogenic effects of SSRIs observed initially during treatment.
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