The inert two-Higgs-doublet Model (i2HDM) is a well-motivated minimal consistent dark matter (DM) model, but it is rather challenging to test at the LHC in the parameter space allowed by relic ...density and DM direct detection constraints. This is especially true when considering the latest XENON 1T data on direct DM searches, which we use here to present the best current combined limit on the i2HDM parameter space. In this analysis, we present prospects to advance the exploitation of DM monojet signatures from the i2HDM at the LHC, by emphasising that a shape analysis of the missing transverse momentum distribution allows one to sizably improve the LHC discovery potential. For a key element of our analysis, we explore the validity of using an effective vertex, ggH, for the coupling of the Higgs boson to gluons using a full one-loop computation. We have found sizeable differences between the two approaches, especially in the high missing transverse momentum region, and incorporated the respective K-factors to obtain the correct kinematical distributions. As a result, we delineate a realistic search strategy and present the improved current and projected LHC sensitivity to the i2HDM parameter space.
The European Association for Palliative Care has initiated a comprehensive program to achieve an over-all review of the evidence of multiple cancer pain management strategies in order to extend the ...current guideline for treatment of cancer pain. The present systematic review analyzed the existing evidence of analgesic efficacy for peripheral nerve blocks in adult patients with cancer. A search strategy was elaborated with words related to cancer, pain, peripheral nerve and block. The search was performed in PubMed, EMBASE, and Cochrane for the period until February 2014. The number of abstracts retrieved was 155. No controlled studies were identified. Sixteen papers presented a total of 79 cases. The blocks applied were paravertebral blocks (10 cases), blocks in the head region (2 cases), plexus blocks (13 cases), intercostal blocks (43 cases) and others (11 cases). In general, most cases reported good pain relief and no side effects. The use of peripheral blocks is based upon anecdotal evidence. However, this review only demonstrates the lack of studies, which does not equal a lack of effectiveness.
Background
The present systematic review analysed the existing evidence of analgesic efficacy and side effects of opioids without and with adjuvant analgesics delivered by neuraxial route (epidural ...and subarachnoid) in adult patients with cancer.
Methods
Search strategy was elaborated with words related to cancer, pain, neuraxial route, analgesic and side effects. The search was performed in PubMed, EMBASE, and Cochrane for the period until February 2014. Studies were analysed according to methods, results, quality of evidence, and strength of recommendation.
Results
The number of s retrieved was 2147, and 84 articles were selected for full reading. The final selection comprised nine articles regarding randomised controlled trials (RCTs) divided in four groups: neuraxial combinations of opioid and adjuvant analgesic compared with neuraxial administration of opioid alone (n = 4); single neuraxial drug in bolus compared with continuous administration (n = 2); single neuraxial drug compared with neuraxial placebo (n = 1); and neuraxial opioid combined with or without adjuvant analgesic compared with other comprehensive medical management than neuraxial analgesics (n = 2). The RCTs presented clinical and methodological diversity that precluded a meta‐analysis. They also presented several limitations, which reduced study internal validity. However, they demonstrated better pain control for all interventions analysed. Side effects were described, but there were few significant differences in favour of the tested interventions.
Conclusion
Heterogeneous characteristics and several methodological limitations of the studies resulted in evidence of low quality and a weak recommendation for neuraxial administration of opioids with or without adjuvant analgesics in adult patients with cancer.
Allogeneic hematopietic stem cell transplantation (aHSCT) is widely used for the treatment of hematologic malignancies. Although aHSCT provides a good response against the malignant cells ...(graft-versus-leukemia GVL), it also leads to the development of graft-versus-host disease (GVHD), a severe disease with high mortality and morbidity rates. Therapy for GVHD is commonly based on nonspecific immunosupression of the transplanted recipient, resulting in the concomitant inhibition of the GVL effect. In this study, we propose an alternative approach to specifically suppress GVHD while sparing the GVL, based on oral treatment of transplant donors with recipient Ags, associated with the intake of probiotic Lactococcus lactis as tolerogenic adjuvant (combined therapy). We show that treatment of C57BL/6 donor mice with combined therapy before the transplant protects the recipients F1 (C57BL/6 × BAL/c) mice from clinical and pathological manifestations of disease, resulting in 100% survival rate. Importantly, the animals keep the immunological competence maintaining the GVL response as well as the response to third-party Ags. The protection is specific, long lasting and dependent on donor IL-10-sufficient B cells activity, which induces regulatory T cells in the host. These data suggest that combined therapy is a promising strategy for prevention of GVHD with preservation of GVL, opening new possibilities to treat human patients subjected to transplantation.
Highlights • An evidence-based assessment of sympathetic blocks for abdominal cancer patients showed that the quality of these studies was generally poor due to several limitations. • Celiac plexus ...block, regardless of the technique used, improved analgesia and/or decrease in opioid consumption, and decreased opioid–induced adverse effects in comparison with a conventional analgesic treatment, as confirmed by two studies of good quality. • Superior hypogastric plexus block determined a decrease in pain intensity and a less morphine consumption in one study. • On the basis of existing evidence, CPB has a strong recommendation in patients with pancreatic cancer pain, while there is a weak recommendation for superior hypogastric plexus block that should be based on individual conditions.
Evidence for a B-s(0)pi(+/-) State Askew, A.; Aushev, V.; Avila, C. ...
Physical review letters,
07/2016, Letnik:
117, Številka:
2
Journal Article
Recenzirano
Odprti dostop
We report evidence for a narrow structure, X(5568), in the decay sequence X(5568) -> B-s(0)pi(+/-), B-s(0) -> J/psi phi, J/psi -> mu(+)mu(-), phi -> K+K-. This is evidence for the first ...instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m = 5567.8 +/- 2.9(stat)(-1.9)(+0.9) (syst) MeV/c(2) and Gamma = 21.9 +/- 6.4(stat)(-2.5)(+5.0) (syst) MeV/c(2). If the decay is X(5568) -> B-s*pi(+/-). B-s(0)gamma pi(+/-) with an unseen gamma, m(X(5568)) will be shifted up by m(B-s*) - m(B-s(0)) similar to 49 MeV/c(2). This measurement is based on 10.4 fb(-1) of p (p) over bar collision data at root s = 1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider.
We present evidence for the exotic charged charmoniumlike state Zc±(3900) decaying to J/ψπ± in semi-inclusive weak decays of b-flavored hadrons. The signal is correlated with a parent J/ψπ+π− system ...in the invariant-mass range 4.2–4.7 GeV that would include the exotic structure Y(4260). The study is based on 10.4 fb−1 of pp¯ collision data collected by the D0 experiment at the Fermilab Tevatron collider.
The branching fraction for the decays of gluinos to third generation quarks is expected to be enhanced in classes of supersymmetric models where either third generation squarks are lighter than other ...squarks, or in mixed-higgsino dark matter models constructed so as to be in concordance with the measured density of cold dark matter. In such scenarios, gluino production events at the CERN Large Hadron Collider should be rich in top and bottom quark jets. Requiring
b
jets in addition to
E
T
miss
should, therefore, enhance the supersymmetry signal relative to Standard Model backgrounds from
V
+ jet,
VV
and QCD backgrounds (
V
=
W
,
Z
). We quantify the increase in the supersymmetry reach of the LHC from
b
-tagging in a variety of well-motivated models of supersymmetry. We also explore “top tagging” at the LHC. We find that while the efficiency for this turns out to be too low to give an increase in reach beyond that obtained via
b
-tagging, top tagging can indeed provide a confirmatory signal if gluinos are not too heavy. We also examine
c
jet tagging but find that it is not useful at the LHC. Finally, we explore the prospects for detecting the direct production of third generation squarks in models with an inverted squark mass hierarchy. This is signaled by
b
jets +
E
T
miss
events being harder than in the Standard Model, but softer than those from the production of gluinos and heavier squarks. We find that while these events can be readily separated from the SM background (for third generation squark masses ∼300–500 GeV), the contamination from the much heavier gluinos and squarks remains formidable if these are also accessible.
We present a measurement of the W boson production charge asymmetry in p$\bar{p}$→W+X→eν+X events at a center of mass energy of 1.96 TeV, using 9.7 fb-1 of integrated luminosity collected with the D0 ...detector at the Fermilab Tevatron Collider. The neutrino longitudinal momentum is determined by using a neutrino weighting method, and the asymmetry is measured as a function of the W boson rapidity. The measurement extends over wider electron pseudorapidity region than previous results and is the most precise to date, allowing for precise determination of proton parton distribution functions in global fits.
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