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zadetkov: 23
1.
  • Comparative expression path... Comparative expression pathway analysis of human and canine mammary tumors
    Uva, Paolo; Aurisicchio, Luigi; Watters, James ... BMC genomics, 03/2009, Letnik: 10, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and ...
Celotno besedilo

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2.
  • Spheres derived from lung a... Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment
    Mancini, Rita; Giarnieri, Enrico; De Vitis, Claudia ... PloS one, 07/2011, Letnik: 6, Številka: 7
    Journal Article
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    Malignant pleural effusions (MPEs) could represent an excellent source to culture a wide variety of cancer cells from different donors. In this study, we set up culture conditions for cancer cells ...
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3.
  • Novel anti-ErbB3 monoclonal... Novel anti-ErbB3 monoclonal antibodies show therapeutic efficacy in xenografted and spontaneous mouse tumors
    Aurisicchio, Luigi; Marra, Emanuele; Luberto, Laura ... Journal of cellular physiology, October 2012, Letnik: 227, Številka: 10
    Journal Article
    Recenzirano

    The role of the ErbB3 receptor in signal transduction is to augment the signaling repertoire of active heterodimeric ErbB receptor complexes through activating the PI3K/AKT pathway, which in turn ...
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4.
  • A Vaccine Targeting Telomer... A Vaccine Targeting Telomerase Enhances Survival of Dogs Affected by B-cell Lymphoma
    Peruzzi, Daniela; Gavazza, Alessandra; Mesiti, Giuseppe ... Molecular therapy, 08/2010, Letnik: 18, Številka: 8
    Journal Article
    Recenzirano
    Odprti dostop

    Canine cancers occur with an incidence similar to that of humans and share many features with human malignancies including histological appearance, tumor genetics, biological behavior, and response ...
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5.
  • Immunization against propro... Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice
    Fattori, Elena; Cappelletti, Manuela; Lo Surdo, Paola ... Journal of lipid research, August 2012, 2012-Aug, 2012-08-00, 20120801, 2012-08-01, Letnik: 53, Številka: 8
    Journal Article
    Recenzirano
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    Successful development of drugs against novel targets crucially depends on reliable identification of the activity of the target gene product in vivo and a clear demonstration of its specific ...
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6.
  • The role of oncogenic Ras i... The role of oncogenic Ras in human skin tumorigenesis depends on the clonogenic potential of the founding keratinocytes
    Maurelli, Riccardo; Tinaburri, Lavinia; Gangi, Fabio ... Journal of cell science, 03/2016, Letnik: 129, Številka: 5
    Journal Article
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    The role of Ras in human skin tumorigenesis induction is still ambiguous. Overexpression of oncogenic Ras causes premature senescence in cultured human cells and hyperplasia in transgenic mice. Here, ...
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7.
  • Telomerase and HER-2/ neu a... Telomerase and HER-2/ neu as targets of genetic cancer vaccines in dogs
    Peruzzi, Daniela; Mesiti, Giuseppe; Ciliberto, Gennaro ... Vaccine, 02/2010, Letnik: 28, Številka: 5
    Journal Article
    Recenzirano

    Abstract Pet dogs represent a valuable pre-clinical model to assess the efficacy of oncology drugs. Additionally, canine cancers occur with an incidence similar to that of humans and share many ...
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8.
  • Downregulation of Notch pat... Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model
    Efferson, Clay L; Winkelmann, Christopher T; Ware, Christopher ... Cancer research, 03/2010, Letnik: 70, Številka: 6
    Journal Article
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    ERBB2/neu and Notch signaling are known to be deregulated in many human cancers. However, pathway cross-talk and dependencies are not well understood. In this study, we use an ERBB2-transgenic mouse ...
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9.
  • A Novel Series of Potent an... A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo
    Jones, Philip; Altamura, Sergio; De Francesco, Raffaele ... Journal of medicinal chemistry, 04/2008, Letnik: 51, Številka: 8
    Journal Article
    Recenzirano

    Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy, and the first generation HDAC inhibitors are currently in the clinic. Entirely novel ketone HDAC inhibitors have ...
Celotno besedilo
10.
  • Therapeutic vaccination halts disease progression in BALB-neuT mice: the amplitude of elicited immune response is predictive of vaccine efficacy
    Cipriani, Barbara; Fridman, Arthur; Bendtsen, Claus ... Human gene therapy, 07/2008, Letnik: 19, Številka: 7
    Journal Article
    Recenzirano

    The aim of this study was to evaluate the efficacy of genetic vaccination with rat ErbB2 antigen in a therapeutic setting for the BALB-neuT mouse model of mammary carcinoma and to establish ...
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zadetkov: 23

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