•Hydrogel nanocomposite i.e. Gx-cl-P(AA-co-AAm)/Fe3O4 was synthesized as an efficient adsorbent for malachite green.•Incorporation of Fe3O4 MNPs was evidenced by FT-IR, XRD, TEM and SEM–EDX ...studies.•Adsorption isotherm followed Langmuir isotherm model with maximum adsorption capacity of 497.15mg/L.•Desorption studies confirmed the reusability and reproducibility of the adsorbent for the adsorption of malachite green.
Herein we report effective removal of malachite green (MG) from aqueous solution using gum xanthan (Gx)/Fe3O4 magnetic nanoparticles (MNPs) filled hydrogel nanocomposites. Gx-cl-P(AA-co-AAm)/Fe3O4 hydrogel nanocomposite was fabricated via incorporating Fe3O4 magnetic nanoparticles within the polymer matrix of the hydrogel of gum xanthan with co-polymer mixture of poly(acrylic acid-co-acrylamide). Maximum adsorption was observed in the solution of neutral pH with 0.2g/L of Gx-cl-P(AA-co-AAm)/Fe3O4 hydrogel nanocomposite. Adsorption isotherm data was fitted with using five isotherm models like Langmuir, Freundlich, Temkin, Flory–Huggins and Dubinin–Kaganer–Radushkevich isothermal models and adsorption process was found to follow Langmuir isotherm model with maximum adsorption efficiency of 497.15mg/g. Different adsorption kinetics models like pseudo first order, pseudo second order, Elovich, liquid particle diffusion and intra-particle diffusion models were applied to study the mechanism of adsorption. Moreover, adsorption kinetics data fitted well with pseudo second order rate model. Furthermore, thermodynamic studies demonstrate that adsorption process was endothermic and spontaneous. Moreover, adsorption–desorption studies suggests that Gx-cl-P(AA-co-AAm)/Fe3O4 hydrogel nanocomposite can be repeatedly used for the adsorption of MG.
•Interviews suggest that mouse genomics archives lack stable funding.•Sustainability requires archives, journal publishers, and funders to implement incentives, metrics, and enforcement mechanisms ...for archive deposits and use.•Current short-term and nationally focused funding and governance models do not adequately support the role of archives in long-term, transnational endeavours to make and share high-impact resources.•New transnational governance and funding models are needed.
Bio-repositories and databases for biomedical research enable the efficient community-wide sharing of reagents and data. These archives play an increasingly prominent role in the generation and dissemination of bioresources and data essential for fundamental and translational research. Evidence suggests, however, that current funding and governance models, generally short-term and nationally focused, do not adequately support the role of archives in long-term, transnational endeavours to make and share high-impact resources. Our qualitative case study of the International Knockout Mouse Consortium and the International Mouse Phenotyping Consortium examines new governance mechanisms for archive sustainability. Funders and archive managers highlight in interviews that archives need stable public funding and new revenue-generation models to be sustainable. Sustainability also requires archives, journal publishers, and funders to implement appropriate incentives, associated metrics, and enforcement mechanisms to ensure that researchers use archives to deposit reagents and data to make them publicly accessible for academia and industry alike.
Summary
Background
Allergic asthma is a complex disorder characterized by local and systemic T helper type 2 ‐cell responses such as the production of IL‐13, a cytokine associated with the induction ...of airway hyper‐responsiveness (AHR), chronic pulmonary eosinophilia, airway mucus overproduction and eosinophilic oesophagitis.
Objective
Our study aimed to address the therapeutic potential of a human anti‐human IL‐13 IgG4 monoclonal antibody (CAT‐354) in a murine model of respiratory and oesophageal inflammation induced by intratracheal human IL‐13.
Methods
BALB/c mice were treated on days 1 and 3 with CAT‐354 (intraperitoneal injection), and human IL‐13 was injected intratracheally on days 2 and 4. AHR to methacholine, airway eosinophilia in bronchoalveolar lavage fluid, histologic analysis of goblet cell metaplasia and oesophageal eosinophilia were evaluated.
Results
Human IL‐13 induced airway eosinophilia and goblet cell metaplasia in mice in a dose‐dependent manner. Moreover, intratracheal dosing with 25 μg of human IL‐13 was sufficient to induce AHR, goblet cell metaplasia and oesophageal eosinophilia. Pretreatment with CAT‐354 significantly reduced AHR, airway eosinophilia and oesophageal eosinophilia.
Conclusion
These results demonstrate that anti‐human IL‐13 (CAT‐354) is a potential therapeutic treatment for allergic airway and oesophageal diseases.
Solution processed organic-inorganic metal halide perovskite based solar cells are emerging as a new cost effective photovoltaic technology. In the context of increasing the power conversion ...efficiency (PCE) and sustainability of perovskite solar cells (PSC) devices, we comprehensively analyzed a physics-based numerical modelling for doped and un-doped PSC devices. Our analytics emphasized the role of different charge carrier layers from the view point of interfacial adhesion and its influence on charge extraction rate and charge recombination mechanism. Morphological and charge transport properties of perovskite thin film as a function of device architecture are also considered to investigate the photovoltaic properties of PSC. We observed that photocurrent is dominantly influenced by interfacial recombination process and photovoltage has functional relationship with defect density of perovskite absorption layer. A novel contour mapping method to understand the characteristics of current density-voltage (J-V) curves for each device as a function of perovskite layer thickness provide an important insight about the distribution spectrum of photovoltaic properties. Functional relationship of device efficiency and fill factor with absorption layer thickness are also discussed.
Summary
Background
Excessive alcohol use has been reported to be responsible for 80 000 annual deaths in the United States. However, the exact cause of death related to the excessive use of alcohol ...has not been fully explored.
Aim
To assess the effect of alcoholic liver disease (ALD) on all‐cause, liver‐related and cardiovascular mortality using population‐based data.
Methods
Data were obtained from the Third National Health and Nutrition Examination Survey (NHANES III) Linked Mortality Files. Alcohol consumption was estimated as grams per day. Multivariate Cox proportional hazards model was utilised to assess the effects of ALD on follow‐up time to mortality from all causes, cardiovascular disease and liver disease.
Results
A total of 8,306 participants were included ALD (n = 148). Mortality follow‐up data were available for a median time of 178.27 months. Participants with ALD had increased risk for liver‐related mortality adjusted hazard ratios or aHR 7.06 (2.09–23.79), but not for overall mortality aHR 1.14 (0.70–1.85) or cardiovascular mortality aHR 0.61 (0.11–3.25).
Conclusion
Alcoholic liver disease increases the risks for liver‐related mortality but not for cardiac or overall mortality.
In the present paper, the coefficient estimates are found for the class
S
∗
−
1
(
α
)
consisting of inverses of functions in the class of univalent starlike functions of order
α in
D
=
{
z
∈
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:
|
z
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<
1
}
. These estimates extend the work of Krzyz, Libera and Zlotkiewicz J.G. Krzyz, R.J. Libera, E. Zlotkiewicz, Coefficients of inverse of regular starlike functions, Ann. Univ. Mariae Curie-Sklodowska Sect. A 33 (10) (1979) 103–109 who found sharp estimates on only first two coefficients for the functions in the class
S
∗
−
1
(
α
)
. The coefficient estimates are also found for the class
Σ
∗
−
1
(
α
)
, consisting of inverses of functions in the class
Σ
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(
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of univalent starlike functions of order
α in
V
=
{
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:
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|
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∞
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. The open problem of finding sharp coefficient estimates for functions in the class
Σ
∗
(
α
)
stands completely settled in the present work by our method developed here.
An investigation about influence of deposition current density on electrodeposited magnetic film is reported in this paper. Ferromagnetic NiFe thin films were electrodeposited on copper wires of ...100 μm diameter for various electrdepostion current densities ranging from 10 to 60 mA/cm
2
maintaining equal thickness in all films. The composition of deposited film varied with deposition current density and in particular, a composition of Ni
79
Fe
21
was achieved for a current density of 20 mA/cm
2
. The surface microstructure of the film deposited at the current density of 20 mA/cm
2
was found to have excellent smoothness. The coercivity of the film was lowest and highest value of magnetoimpedance was measured for this film. The influence of current density on film composition and hence magnetic properties was attributed to the change of deposition mechanism.
Abstract
Context (Background):
Visual-based screening techniques are low cost and have good sensitivity. Hence, they appear promising for primary screening in low-resource settings. However, to ...reduce referrals for diagnostic colposcopy, there is need to triage these screen-positive women with test with good specificity.
Aims:
The study aims to evaluate the performance of cytology as triage for visual inspection after application of 4% acetic acid (VIA) screen-positive women.
Settings and Design:
Community-based cervical cancer screening using VIA was implemented among socioeconomically disadvantaged women in Mumbai, India.
Methods:
Cytology was performed on screen-positive women. All primarily screen-positive women underwent colposcopy. Directed biopsies were obtained among women with positive findings on colposcopy. The gold standard used for final disease status was histopathology or negative colposcopy.
Statistical Analysis Used:
Test characteristics of cytology as triage test.
Results:
Among the 138,383 population, 16,424 eligible women were screened with VIA. 785 (4.78%) women were VIA positive and 580 women participated in triage with cytology. The sensitivity and specificity of cytology at threshold of atypical squamous cells of undetermined significance in detecting ≥cervical intraepithelial neoplasia (CIN) 2 were 75.0 and 94.7, respectively. The positive and negative predictive values of cytology as triage test were 23.1 and 99.4, respectively, and the false positivity and false negativity rates were 5.34 and 25.0, respectively.
Conclusion:
Cytology triage with VIA can reduce referrals for colposcopy to 4.97% of original referrals but may miss around 25%, of high-grade CIN. The substantial reduction in referrals has special implication for low-resource settings, wherein compliance to referral and availability of diagnostic facilities are poor.
The sense of smell has been largely ignored by otorhinolaryngologists, even though 1) its medical stewardship falls within their specialty's purview, 2) olfactory dysfunction is not uncommon in the ...general population, and 3) disorders of olfaction have significant quality of life, nutritional, and safety consequences. This report provides a succinct overview of the major intranasal neural systems present in humans (namely, cranial nerves O, I, and V, and the nonfunctional accessory vomeronasal organ system), along with a summary of notable findings resulting from the application of modern olfactory tests to patient populations, emphasizing diseases of the nose. Such tests have led to the discovery of significant influences of age, gender, smoking, toxic exposure, and genetics on the ability to smell. Within the field of otorhinolaryngology, they have revealed that 1) surgical and medical interventions in patients with rhinosinusitis do not, on average, lead to complete recovery of olfactory function, despite common beliefs to the contrary, and 2) associations are generally lacking between measures of airway patency and olfactory function in such cases. These findings have thrown into question the dogma that olfactory loss in rhinosinusitis is attributable primarily to blockage of airflow to the receptors and have led to histopathological studies demonstrating significant olfactory epithelial compromise in sinonasal syndromes.
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