In this rich, highly illustrated book, Mieke Bal takes us on a journey through the range of her work, using the concept of image-thinking as a point of connection between cultural analysis and ...artistic practice. Bal teaches us how to think with images, but also how to write and think - as artists and writers - about our own creative work.
Clinical trials have recently evaluated safety and efficacy of neoadjuvant therapy among patients with surgically resectable regional melanoma metastases. To capture informative prognostic data ...connected to pathological response in such trials, it is critical to standardize pathologic assessment and reporting of tumor response after this treatment.
The International Neoadjuvant Melanoma Consortium meetings in 2016 and 2017 assembled pathologists from academic centers to develop consensus guidelines for pathologic examination and reporting of surgical specimens from AJCC (8th edition) stage IIIB/C/D or oligometastatic stage IV melanoma patients treated with neoadjuvant-targeted or immune therapy. Patterns of pathologic response are provided context to inform these guidelines.
Based on our collective experience and guided by efforts in well-established neoadjuvant settings like breast cancer, procedures directing handling of pre- and post-neoadjuvant therapy–treated melanoma specimens are provided to facilitate comparison of findings across different trials and centers. Definitions of pathologic response are provided together with guidelines for reporting and quantifying the extent of pathologic response. Finally, the spectrum of histopathologic responses observed following neoadjuvant-targeted and immune-checkpoint therapy is described and illustrated.
Standardizing pathologic evaluation of resected melanoma metastases following neoadjuvant-targeted or immune-checkpoint therapy allows more robust stratification of patient outcomes. This includes recognizing the spectrum of histopathologic response patterns to neoadjuvant therapy and a standard approach to grading pathologic responses. Such an approach will facilitate comparison of results across clinical trials and inform ongoing correlative studies into the mechanisms of response and resistance to agents applied in the neoadjuvant setting.
The existence of cryovolcanic features on Titan has been the subject of some controversy. Here we use observations from the Cassini RADAR, including Synthetic Aperture Radar (SAR) imaging, ...radiometry, and topographic data as well as compositional data from the Visible and Infrared Mapping Spectrometer (VIMS) to reexamine several putative cryovolcanic features on Titan in terms of likely processes of origin (fluvial, cryovolcanic, or other). We present evidence to support the cryovolcanic origin of features in the region formerly known as Sotra Facula, which includes the deepest pit so far found on Titan (now known as Sotra Patera), flow‐like features (Mohini Fluctus), and some of the highest mountains on Titan (Doom and Erebor Montes). We interpret this region to be a cryovolcanic complex of multiple cones, craters, and flows. However, we find that some other previously supposed cryovolcanic features were likely formed by other processes. Cryovolcanism is still a possible formation mechanism for several features, including the flow‐like units in Hotei Regio. We discuss implications for eruption style and composition of cryovolcanism on Titan. Our analysis shows the great value of combining data sets when interpreting Titan's geology and in particular stresses the value of RADAR stereogrammetry when combined with SAR imaging and VIMS.
Key PointsEvidence to support volcanic origin of features on TitanSeveral Cassini data sets used to support the argumentSotra patera and associated features provide strongest evidence of cryovolcanism
In this paper, we present the analysis and results of a direct measurement of the cosmic-ray proton spectrum with the CALET instrument onboard the International Space Station, including the detailed ...assessment of systematic uncertainties. The observation period used in this analysis is from October 13, 2015 to August 31, 2018 (1054 days). We have achieved the very wide energy range necessary to carry out measurements of the spectrum from 50 GeV to 10 TeV covering, for the first time in space, with a single instrument the whole energy interval previously investigated in most cases in separate subranges by magnetic spectrometers (BESS-TeV, PAMELA, and AMS-02) and calorimetric instruments (ATIC, CREAM, and NUCLEON). The observed spectrum is consistent with AMS-02 but extends to nearly an order of magnitude higher energy, showing a very smooth transition of the power-law spectral index from -2.81±0.03 (50-500 GeV) neglecting solar modulation effects (or -2.87±0.06 including solar modulation effects in the lower energy region) to -2.56±0.04 (1-10 TeV), thereby confirming the existence of spectral hardening and providing evidence of a deviation from a single power law by more than 3σ.
Extended results on the cosmic-ray electron + positron spectrum from 11 GeV to 4.8 TeV are presented based on observations with the Calorimetric Electron Telescope (CALET) on the International Space ...Station utilizing the data up to November 2017. The analysis uses the full detector acceptance at high energies, approximately doubling the statistics compared to the previous result. CALET is an all-calorimetric instrument with a total thickness of 30 X_{0} at normal incidence and fine imaging capability, designed to achieve large proton rejection and excellent energy resolution well into the TeV energy region. The observed energy spectrum in the region below 1 TeV shows good agreement with Alpha Magnetic Spectrometer (AMS-02) data. In the energy region below ∼300 GeV, CALET's spectral index is found to be consistent with the AMS-02, Fermi Large Area Telescope (Fermi-LAT), and Dark Matter Particle Explorer (DAMPE), while from 300 to 600 GeV the spectrum is significantly softer than the spectra from the latter two experiments. The absolute flux of CALET is consistent with other experiments at around a few tens of GeV. However, it is lower than those of DAMPE and Fermi-LAT with the difference increasing up to several hundred GeV. The observed energy spectrum above ∼1 TeV suggests a flux suppression consistent within the errors with the results of DAMPE, while CALET does not observe any significant evidence for a narrow spectral feature in the energy region around 1.4 TeV. Our measured all-electron flux, including statistical errors and a detailed breakdown of the systematic errors, is tabulated in the Supplemental Material in order to allow more refined spectral analyses based on our data.
The discovery of superconductivity in a d9−δ nickelate has inspired disparate theoretical perspectives regarding the essential physics of this class of materials. A key issue is the magnitude of the ...magnetic superexchange, which relates to whether cuprate-like high-temperature nickelate superconductivity could be realized. We address this question using Ni L-edge and O K-edge spectroscopy of the reduced d9−1/3 trilayer nickelates R4Ni3O8 (where R = La Pr) and associated theoretical modeling. A magnon energy scale of ∼ 80 meV resulting from a nearest-neighbor magnetic exchange of J = 69 (4) meV is observed, proving that d9−δ nickelates can host a large superexchange. This value, along with that of the Ni-O hybridization estimated from our O K -edge data, implies that trilayer nickelates represent an intermediate case between the infinite-layer nickelates and the cuprates. Layered nickelates thus provide a route to testing the relevance of superexchange to nickelate superconductivity.
Two wave packets of second harmonic poloidal Pc 4 waves with a wave frequency of ~7 mHz were detected by Van Allen Probe A at a radial distance of ~5.8 RE and magnetic local time of 13 hr near the ...magnetic equator, where plasmaspheric refilling was in progress. Proton butterfly distributions with energy dispersions were also measured at the same time; the proton fluxes at 10–30 keV oscillated with the same frequency as the Pc 4 waves. Using the ion sounding technique, we find that the Pc 4 waves propagated eastward with an azimuthal wave number (m number) of ~220 and ~260 for each wave packet, respectively. Such eastward propagating high‐m (m > 100) waves were seldom reported in previous studies. The condition of drift‐bounce resonance is well satisfied for the estimated m numbers in both events. Proton phase space density was also examined to understand the wave excitation mechanism. We obtained temporal variations of the energy and radial gradient of the proton phase space density and find that temporal intensification of the radial gradient can generate the two wave packets. The cold electron density around the spacecraft apogee was >100 cm−3 in the present events, and hence the eigenfrequency of the Pc 4 waves became lower. This causes the increase of the m number which satisfies the resonance condition of drift‐bounce resonance for 10–30 keV protons and meets the condition for destabilization due to gyrokinetic effect.
Key Points
The first direct observation of drift‐bounce resonance that excites eastward propagating second harmonic poloidal waves with high m number
These waves are excited by intensification of radial gradient of proton phase space density due to substorm injection
Cold electrons also contribute to the wave excitation by increasing the m number to satisfy gyro‐kinetic destabilization condition
Context.
The observation of numerous magnetic switchbacks and associated plasma jets in Parker Solar Probe (PSP) during its first five orbits, particularly near the Sun, has attracted considerable ...attention. Switchbacks have been found to be systematically associated with correlated reversals in the direction of the propagation of Alfvénic fluctuations, as well as similar reversals of the electron strahl.
Aims.
Here we aim to see whether the energetic particles change direction at the magnetic field switchbacks.
Methods.
We use magnetic field data from the MAG suite’s fluxgate magnetometer instrument to identify switchback regions. We examine the radial anisotropy of the energetic particles measured by the EPI-Lo instrument of the IS⊙IS suite.
Results.
We find that energetic particles measured by EPI-Lo generally do not preferentially change their directionality from that of the background magnetic field to that of the switchbacks.
Conclusions.
A reasonable hypothesis is that particles with smaller gyroradii, such as strahl electrons, can reverse direction by following the magnetic field in switchbacks, but that larger gyroradii particles cannot. This provides the possibility of setting a constraint on the radius of the curvature of the magnetic field in switchbacks, a property not otherwise observed by PSP. We expect that particles at higher energies than those detectable by EPI-Lo will also not respond to switchbacks. The observed reversals of radial energetic particle flux are separate phenomena, likely associated with source locations or other propagation effects occurring at greater radial distances.
Considerable effort has been put into the application of quantitative microbiological risk assessment for
Listeria monocytogenes, and data are available for England and Wales (probably more so than ...most other countries) on the adverse health effects, together with incidence data on different age and risk groups for human
L. monocytogenes infections. This paper reviews aspects of
Listeria and human listeriosis, especially from a public health perspective and provide hazard characterisation data, i.e. the qualitative and/or quantitative evaluation of the adverse health effect associated with the hazard, which is the relationship between exposure levels (dose) and frequency of illness.
The majority of cases of human listeriosis are food-borne; however, the disease process is complex with multiple routes of infection. The dose–response relationship is poorly understood, and data from human volunteer studies are not available and would be unethical to produce. Data are available from a range of different animal and in vitro models, although these poorly mimic the natural disease process in route of infection, end point, host and history of prior exposure to the bacterium. Epidemiological data provide some information on infective doses and dose responses, but because of the characteristics of the disease (the hugely variable and potentially very long incubation periods, the low attack rates and the rarity of identification of specific food vehicles), this also provides limited data for calculation of dose responses. There is some, albeit limited, evidence for strain variation, but this is an area of considerable uncertainty despite great advances in the genetic basis of the virulence of this bacterium, and almost all strains seem capable of causing serious disease. A variety of mathematical approaches have been used to model dose responses. The review is written to provide a clinical and epidemiological background to the mathematically oriented, as well as to outline the mathematical approaches to those interested in food-borne infection.
The Radiation Belt Storm Probes Ion Composition Experiment (RBSPICE) on the two Van Allen Probes spacecraft is the magnetosphere ring current instrument that will provide data for answering the three ...over-arching questions for the Van Allen Probes Program: RBSPICE will determine “how space weather creates the storm-time ring current around Earth, how that ring current supplies and supports the creation of the radiation belt populations,” and how the ring current is involved in radiation belt losses. RBSPICE is a time-of-flight versus total energy instrument that measures ions over the energy range from ∼20 keV to ∼1 MeV. RBSPICE will also measure electrons over the energy range ∼25 keV to ∼1 MeV in order to provide instrument background information in the radiation belts. A description of the instrument and its data products are provided in this chapter.
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