A
bstract
We report a new measurement of the
e
+
e
−
→
ϒ(
nS
)
π
+
π
−
(
n
= 1
,
2
,
3) cross sections at energies from 10
.
52 to 11
.
02 GeV using data collected with the Belle detector at the KEKB ...asymmetric-energy
e
+
e
−
collider. We observe a new structure in the energy dependence of the cross sections; if described by a Breit-Wigner function its mass and width are found to be
M
=
10752.7
±
5.9
−
1.1
+
0.7
MeV
/
c
2
and
Γ
=
35.5
−
11.3
−
3.3
+
17.6
+
3.9
MeV, where the first error is statistical and the second is systematic. The global significance of the new structure including systematic uncertainty is 5.2 standard deviations. We also find evidence for the
e
+
e
−
→
ϒ (1
S
)
π
+
π
−
process at the energy 10
.
52 GeV, which is below the
B
B
¯
threshold.
Radiation-enhanced diffusion (RED) of copper (Cu) in iron (Fe) is essential for understanding solute/impurity diffusion in nuclear materials, especially reactor pressure vessel steel, but has been ...rarely reported experimentally. In this study, we performed a high-precision investigation of RED using well-controlled electron irradiation and three-dimensional atom probe (3D-AP). Cu-Fe diffusion pairs were created using high-purity Fe and Cu as base materials, and irradiated by 2 MeV electron at a temperature of 773 – 893 K controlled to within ±3 K. Cu diffusion into the Fe matrix was observed at the atomic level using 3D-AP, and the diffusion coefficient was obtained directly using Fick's law. RED was clearly observed, and the ratio of diffusion under irradiation to thermal diffusion was increased as the irradiation temperature decreased. RED was quantitatively evaluated using the reaction kinetics model, and the model which consider only vacancies gave a good agreement. This gave experimental clarification that RED was dominated by irradiation-induced vacancies. In addition, the direct experimental results on the effect of irradiation on the solubility limits of Cu in Fe was obtained; solubility limits under irradiation were found to be lower than those under thermal aging.
We study B --> K(*)l+l- decays (l = e, mu) based on a data sample of 657 x 10(6) BB pairs collected with the Belle detector at the KEKB e+e- collider. We report the differential branching fraction, ...isospin asymmetry, K* polarization, and the forward-backward asymmetry (A(FB)) as functions of q2 = M(ll)(2)c2. The fitted A(FB) spectrum exceeds the standard model expectation by 2.7 standard deviations. The measured branching fractions are B(B --> K*l+l-) = (10.7(-1.0)(+1.1) +/- 0.9) x 10(-7) and B(B --> Kl+l-) = (4.8(-0.4)(+0.5) +/- 0.3) x 10(-7), where the first errors are statistical and the second are systematic, with the muon to electron ratios R(K*) = 0.83 +/- 0.17 +/- 0.08 and R(K) = 1.03 +/- 0.19 +/- 0.06.
Circulating tumour DNA (ctDNA) is an emerging candidate biomarker for malignancies and may be useful for monitoring the disease status of gastric cancer.
We performed targeted deep sequencing of ...plasma cell-free DNA (cfDNA) by massively parallel sequencing in patients with tumours harbouring TP53 mutations. The quantitative values of TP53-ctDNA during the clinical course were compared with the tumour status.
Three out of ten patients with TP53 mutations in primary tumours showed detectable TP53 mutation levels in preoperative cfDNA. Although the cfDNA concentrations were not always reflective of the disease course, the ctDNA fraction correlated with the disease status.
ctDNA may serve as a useful biomarker to monitor gastric cancer progression and residual disease.
The cross section for e+ e- --> pi+ pi- psi(2S) between threshold and sqrts=5.5 GeV is measured using 673 fb(-1) of data on and off the Upsilon(4S) resonance collected with the Belle detector at ...KEKB. Two resonant structures are observed in the pi+ pi- psi(2S) invariant-mass distribution, one at 4361 +/- 9 +/- 9 MeV/c2 with a width of 74 +/- 15 +/- 10 MeV/c2, and another at 4664 +/- 11 +/- 5 MeV/c2 with a width of 48 +/- 15 +/- 3 MeV/c2, if the mass spectrum is parametrized with the coherent sum of two Breit-Wigner functions. These values do not match those of any of the known charmonium states.
We report a study of B→(J/ψγ)K and B→(ψ'γ)K decay modes using 772×10⁶ B ̅B events collected at the Υ(4S) resonance with the Belle detector at the KEKB energy-asymmetric e(+)e(-) collider. We observe ...X(3872)→J/ψγ and report the first evidence for χ(c2)→J/ψγ in B→(X_{c ̅cγ)K decays, while in a search for X(3872)→ψ'γ no significant signal is found. We measure the branching fractions, B(B(±)→X(3872)K(±))B(X(3872)→J/ψγ)=(1.78(-0.44)(+0.48)±0.12)×10(-6), B(B(±)→χ(c2)K(±))=(1.11(-0.34)(+0.36)±0.09)×10(-5), B(B(±)→X(3872)K(±))B(X(3872)→ψ'γ)<3.45×10⁶ (upper limit at 90% C.L.), and also provide upper limits for other searches.
CD133 and CD44 are putative cancer stem cell (CSC) markers in colorectal cancer (CRC). However, their clinical significance is currently unclear. Here, we evaluated primary CRC cell isolates to ...determine the significance of several CSC markers, including CD133 and CD44, as predictors of tumourigenesis and prognosis.
CD133- and CD44-positive cells from fresh clinical samples of 77 CRCs were selected by flow cytometric sorting and evaluated for tumourigenicity following subcutaneous transplantation into NOD/SCID mice. Cancer stem cell marker expression was examined in both xenografts and a complementary DNA library compiled from 167 CRC patient samples.
CD44(+), CD133(+) and CD133(+)CD44(+) sub-populations were significantly more tumourigenic than the total cell population. The clinical samples expressed several transcript variants of CD44. Variant 2 was specifically overexpressed in both primary tumours and xenografts in comparison with the normal mucosa. A prognostic assay using qRT-PCR showed that the CD44v2(high) group (n=84, 5-year survival rate (5-OS): 0.74) had a significantly worse prognosis (P=0.041) than the CD44v2(low) group (n=83, 5-OS: 0.88).
CD44 is an important CSC marker in CRC patients. Furthermore, CRC patients with high expression of CD44v2 have a poorer prognosis than patients with other CD44 variants.
The Japanese prime minister declared a state of emergency on April 7 2020 to combat the outbreak of coronavirus disease 2019 (COVID-19). This declaration was unique in the sense that it was ...essentially driven by the voluntary restraint of the residents. We examined the change of the infection route by investigating contact experiences with COVID-19–positive cases.
This study is a population-level questionnaire-based study using a social networking service (SNS).
To assess the impact of the declaration, this study used population-level questionnaire data collected from an SNS with 121,375 respondents (between March 27 and May 5) to assess the change in transmission routes over the study period, which was measured by investigating the association between COVID-19–related symptoms and (self-reported) contact with COVID-19–infected individuals.
The results of this study show that the declaration prevented infections in the workplace, but increased domestic infections as people stayed at home. However, after April 24, workplace infections started to increase again, driven by the increase in community-acquired infections.
While careful interpretation is necessary because our data are self-reported from voluntary SNS users, these findings indicate the impact of the declaration on the change in transmission routes of COVID-19 over time in Japan.
•After a weak lockdown, the transmission route of coronavirus disease 2019 (COVID-19)–related symptoms changed.•COVID-19 monitoring responses from more than 120,000 social networking service users in Japan were used for analysis.•The emergency declaration prevented infections in the workplace and increased domestic infections.•Even lockdown with limited enforcement may prevent the spread of infection.
The cross section for e(+)e(-)-->pi(+)pi(-)J/psi between 3.8 and 5.5 GeV/c(2) is measured using a 548 fb(-1) data sample collected on or near the Upsilon(4S) resonance with the Belle detector at ...KEKB. A peak near 4.25 GeV/c(2), corresponding to the so called Y(4260), is observed. In addition, there is another cluster of events at around 4.05 GeV/c(2). A fit using two interfering Breit-Wigner shapes describes the data better than one that uses only the Y(4260), especially for the lower-mass side of the 4.25 GeV enhancement.
We report the analysis of the three-body e^{+}e^{-}→BBover ¯π^{±}, BBover ¯^{*}π^{±}, and B^{*}Bover ¯^{*}π^{±} processes, including the first observations of the Z_{b}^{±}(10610)→BBover ...¯^{*}+c.c.^{±} and Z_{b}^{±}(10650)→B^{*}Bover ¯^{*}^{±} transitions that are found to dominate the corresponding final states. We measure Born cross sections for the three-body production of σ(e^{+}e^{-}→BBover ¯^{*}+c.c.^{±}π^{∓})=17.4±1.6(stat)±1.9(syst) pb and σ(e^{+}e^{-}→B^{*}Bover ¯^{*}^{±}π^{∓})=8.75±1.15(stat)±1.04(syst) pb and set a 90% C.L. upper limit of σ(e^{+}e^{-}→BBover ¯^{±}π^{∓})<2.9 pb. The results are based on a 121.4 fb^{-1} data sample collected with the Belle detector at a center-of-mass energy near the ϒ(10860) peak.
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