This study aimed to determine possible association of eight polymorphisms of seven MMP genes with essential hypertension (EH) in a Caucasian population of Central Russia. Eight SNPs of the MMP1, ...MMP2, MMP3, MMP7, MMP8, MMP9, and MMP12 genes and their gene-gene (epistatic) interactions were analyzed for association with EH in a cohort of 939 patients and 466 controls using logistic regression and assuming additive, recessive, and dominant genetic models. The functional significance of the polymorphisms associated with EH and 114 variants linked to them (r
≥ 0.8) was analyzed in silico. Allele G of rs11568818 MMP7 was associated with EH according to all three genetic models (OR = 0.58-0.70, p
= 0.01-0.03). The above eight SNPs were associated with the disorder within 12 most significant epistatic models (OR = 1.49-1.93, p
< 0.02). Loci rs1320632 MMP8 and rs11568818 MMP7 contributed to the largest number of the models (12 and 10, respectively). The EH-associated loci and 114 SNPs linked to them had non-synonymous, regulatory, and eQTL significance for 15 genes, which contributed to the pathways related to metalloendopeptidase activity, collagen degradation, and extracellular matrix disassembly. In summary, eight studied SNPs of MMPs genes were associated with EH in the Caucasian population of Central Russia.
Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases (MMP) genes (rs1799750 MMP1, rs3918242 and ...rs17576 MMP9) in Russian patients with primary open-angle glaucoma (POAG), essential hypertension (EH) and peptic ulcer (PU) are presented. Association studies identified these SNPs as possible significant markers associated with many multifactorial disorders, including POAG, EH, and PU. The frequencies of alleles and genotypes of the three SNPs in Russian patients with POAG, EH, and PU were presented separately for the entire study sample, females, and males, respectively. The data can be used as a reference for the Russian population.
In this paper, we described a computational approach in educational assessment and illustrated it with an interactive textbook of mathematics for undergraduate students. To maintain the validity of ...assessment results, we used evidence-centered design since data collection in psychometrics is aligned with a theoretical framework. However, the results of computational methods can be used as collateral information to extend psychometric models.
We live in a time of globalization. People and events of one country often impact other countries. The term “globalization” became one of the main characteristics of today‟s world. Countries perceive ...themselves not only as separate nations but also as parts of the global world. On other hand, new product development field is a complex process that is vital for companies‟ growth and success. Today, in terms of globalization, success of the product can be judged by its performance on the global market. Reduction of trade barriers and duty, development of new technologies and communication channels and other factors cause a trend towards development of the global market. In such conditions, a challenging task of new product development becomes even more challenging. It transforms into a new process that aims to take advantages of global opportunities and increase efficiency and effectiveness of new products.The new product development theory is quite a researched field. Numerous studies were conducted in the field of global strategies as well. These two concepts, however, were always investigated separately and just little research has been conducted about the joint topic. There are no studies that analyze the new product development process in global companies. Brentani, Kleinschmidt and Salomo (2010) argue though that global company strategy, corporate global culture and global innovation strategy affects the new product development process that is conducted by global companies. Thus we can find a research gap in contemporary literature that studies the global development process in global companies. Thereby the purpose of the current research is to investigate and integrate diverse knowledge about this process and global company strategy. It contributes to the contemporary knowledge about the new product development process by adding global perspective to this concept. Moreover, the current study can provide a framework for companies that can be considered during the process of development of new products for the global market.Our research, therefore, aims to answer the research question: How is the new product development (NPD) process run in global companies: what are the differences with the traditional NPD model and by whom and how is this process managed?By conduction of qualitative interviews and content analysis of gathered data, the new product development process was investigated in three global companies. Further, relevant theories about new product development and global company strategy and gathered data were analyzed together. Based on this comprehensive analysis a new improved model was suggested for the new product development process in global companies. Besides this, managerial issues of this process were investigated as well and some propositions were developed.
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Självständigt arbete på avancerad nivå (masterexamen)
20 poäng / 30 hp
We live in a time of globalization. People and events of one country often impact other countries. The term “globalization” became one of the main characteristics of today‟s world. Countries perceive themselves not only as separate nations but also as parts of the global world. On other hand, new product development field is a complex process that is vital for companies‟ growth and success. Today, in terms of globalization, success of the product can be judged by its performance on the global market. Reduction of trade barriers and duty, development of new technologies and communication channels and other factors cause a trend towards development of the global market. In such conditions, a challenging task of new product development becomes even more challenging. It transforms into a new process that aims to take advantages of global opportunities and increase efficiency and effectiveness of new products.The new product development theory is quite a researched field. Numerous studies were conducted in the field of global strategies as well. These two concepts, however, were always investigated separately and just little research has been conducted about the joint topic. There are no studies that analyze the new product development process in global companies. Brentani, Kleinschmidt and Salomo (2010) argue though that global company strategy, corporate global culture and global innovation strategy affects the new product development process that is conducted by global companies. Thus we can find a research gap in contemporary literature that studies the global development process in global companies. Thereby the purpose of the current research is to investigate and integrate diverse knowledge about this process and global company strategy. It contributes to the contemporary knowledge about the new product development process by adding global perspective to this concept. Moreover, the current study can provide a framework for companies that can be considered during the process of development of new products for the global market.Our research, therefore, aims to answer the research question: How is the new product development (NPD) process run in global companies: what are the differences with the traditional NPD model and by whom and how is this process managed?By conduction of qualitative interviews and content analysis of gathered data, the new product development process was investigated in three global companies. Further, relevant theories about new product development and global company strategy and gathered data were analyzed together. Based on this comprehensive analysis a new improved model was suggested for the new product development process in global companies. Besides this, managerial issues of this process were investigated as well and some propositions were developed.
We live in a time of globalization. People and events of one country often impact other countries. The term “globalization” became one of the main characteristics of today‟s world. Countries perceive ...themselves not only as separate nations but also as parts of the global world. On other hand, new product development field is a complex process that is vital for companies‟ growth and success. Today, in terms of globalization, success of the product can be judged by its performance on the global market. Reduction of trade barriers and duty, development of new technologies and communication channels and other factors cause a trend towards development of the global market. In such conditions, a challenging task of new product development becomes even more challenging. It transforms into a new process that aims to take advantages of global opportunities and increase efficiency and effectiveness of new products.The new product development theory is quite a researched field. Numerous studies were conducted in the field of global strategies as well. These two concepts, however, were always investigated separately and just little research has been conducted about the joint topic. There are no studies that analyze the new product development process in global companies. Brentani, Kleinschmidt and Salomo (2010) argue though that global company strategy, corporate global culture and global innovation strategy affects the new product development process that is conducted by global companies. Thus we can find a research gap in contemporary literature that studies the global development process in global companies. Thereby the purpose of the current research is to investigate and integrate diverse knowledge about this process and global company strategy. It contributes to the contemporary knowledge about the new product development process by adding global perspective to this concept. Moreover, the current study can provide a framework for companies that can be considered during the process of development of new products for the global market.Our research, therefore, aims to answer the research question: How is the new product development (NPD) process run in global companies: what are the differences with the traditional NPD model and by whom and how is this process managed?By conduction of qualitative interviews and content analysis of gathered data, the new product development process was investigated in three global companies. Further, relevant theories about new product development and global company strategy and gathered data were analyzed together. Based on this comprehensive analysis a new improved model was suggested for the new product development process in global companies. Besides this, managerial issues of this process were investigated as well and some propositions were developed.
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