Pain in Parkinson's disease patients Maria-Lucia Muntean; Lacramioara Perju Dumbrava
Romanian journal of neurology,
09/2009, Letnik:
8, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Parkinson’s disease is characterized by motor features, which represent diagnostic criteria and non-motor symptoms that have greater significance when assessed by quality-of-life measures. Pain is a ...part of the large spectrum of non-motor symptoms. It can occur in any stage of the disease, even in the premotor-phase. Its prevalence varies between 38% and 85%, depending on the study design and inclusion criteria. Pain in PD can be classified using different criteria: its relation to PD or depending on the aggravating factors. The pathology of pain in PD in not completely clarified, but the basal ganglia seem to play an important role in the processing of pain signals. One can assess pain by measuring the pain threshold or by using scales. Treating pain in PD patients can be difficult and it implies a good management of antiparkinsonian medication, NSAIDs, antidepressants, antiepileptic drugs and physical therapy.
Elderly and patients with neurodegenerative diseases (NDD) often complain about sleep problems and show altered sleep structure. Automated algorithms for efficient and specific sleep staging are ...needed. We propose a new algorithm using only one electroencephalographic and two electrooculographic channels to score wakefulness, rapid eye movement (REM) sleep and non-REM sleep in a cohort of elderly healthy controls (HC), patients with Parkinson's disease (PD), isolated REM sleep behavior disorder (iRBD), considered the prodromal stage of PD, and patients with PD and RBD (PD+RBD). The proposed method scores both standard 30-s epochs (macro-staging) and 5-s mini-epochs (micro-staging), whose evaluation may help to better understand sleep micro-structure. Moreover, the algorithm is interactive, as it labels the classified sleep epochs as either certain or uncertain, so that experts can manually review the uncertain ones. The algorithm performances were evaluated for macro-sleep staging, where it achieved overall accuracies of 0.87±0.05 in 41 HC, 0.86±0.10 in 57 PD, 0.76±0.10 in 31 iRBD and 0.77±0.10 in 30 PD+RBD patients when all 30-s epochs were considered. The accuracies increased to 0.91±0.05, 0.90±0.08, 0.85±0.09, 0.88±0.08 respectively when considering only the certain ones. The epochs labeled as uncertain were 9.95±4.15%, 11.13±7.86%, 18.39±7.38% and 18.90±8.00% in HC, PD, iRBD and PD+RBD respectively. The proposed interactive micro and macro sleep staging algorithm can be used in clinics to reduce the burden of manual sleep staging in elderly and patients with NDD.
Curcumin’s role in the treatment of ulcerative colitis (UC) has been proven by numerous studies, but its preventive administration, with the aim of reducing the remission episodes that are ...characteristic of this disease, must be further investigated. This study investigates the effects of a novel curcumin-loaded polymeric microparticulate oral-drug-delivery system for colon targeting (Col-CUR-MPs) in an experimental model of UC. Male Wistar rats (n = 40) were divided into five groups (n = 8), which were treated daily by oral gavage for seven days with a 2% aqueous solution of carboxymethylcellulose sodium salt (CMCNa) (healthy and disease control), free curcumin powder (reference), Col-CUR-MPs (test) and prednisolone (reference) prior to UC induction by the intrarectal administration of acetic acid (AA), followed by animal sacrification and blood and colonic samples’ collection on the eighth day. Col-CUR-MPs exhibited an important preventive effect in the severity degree of oxidative stress that resulted following AA intrarectal administration, which was proved by the highest catalase (CAT) and total antioxidant capacity (TAC) levels and the lowest nitrites/nitrates (NOx), total oxidative status (TOS) and oxidative stress index (OSI) levels. Biochemical parameter analysis was supported by histopathological assessment, confirming the significant anti-inflammatory and antioxidant effects of this novel colon-specific delivery system in AA-induced rat models of UC. Thus, this study offers encouraging perspectives regarding the preventive administration of curcumin in the form of a drug delivery system for colon targeting.
Knowledge about the geographical areas preferred by grapevine moths, the size of the populations, and the attraction to certain cultivars supports winegrowers for a better zoning of vineyards and ...vine cultivars, which is in continuing dynamic due to the climate change. Grapevine moths Lobesia botrana (Denis & Schiffermüller) and Eupoecilia ambiguella (Hübner) are the main pests of grapes in the Târnave vineyard. For this reason, the influence of the cultivar in the climatic conditions of 2016–2019 period on the dynamics of the two moths species was evaluated in five plantations (Jidvei, Șona, Sâmniclăuș, Tăuni and Cenade) from Târnave vineyards on five cultivars Fetească regală, Sauvignon blanc, Chardonnay, Traminer and Rhine Riesling. During the studied period, the climate experienced deviations from the multiannual values. Our results highlight different activities of the two moth species. The number of captures was influenced by climatic conditions, geographical area and grape cultivar. L. botrana prefers drier climates, lower geographical areas and Traminer cultivar; meanwhile, E. ambiguella prefers wetter climates, higher hilly areas and the Sauvignon blanc cultivar. These findings are important in the general context of grapevine protection in order to reduce the use of pesticides by choosing the right cultivars in the appropriate climate conditions.
Vitis vinifera, known as the common grape vine, represents one of the most important fruit crops in the world. Romania is a wine-producing country with a rich and long tradition in viticulture. In ...the last decade, increasing reports of damage caused by grapevine trunk diseases (GTDs) have raised concerns in all wine producing countries. Up to now, no study was performed regarding the GTDs situation in Romania, an important grapevine grower in Europe. In this study, we aim, after a comprehensive presentation of the fungal GTDs worldwide, to review the scientific information related to these diseases in Romania in order to open a national platform in an international framework. In order to achieve this, we consulted over 500 references from different scientific databases and cited 309 of them. Our review concludes that, in Romania, there is little amount of available literature on this matter. Three out of six fungal GTDs are reported and well documented in all of the Romanian viticultural zones (except for viticultural zone 4). These are Eutypa dieback, Phomopsis dieback, and Esca disease. Of the fungal pathogens considered responsible Eutypa lata, Phomopsis viticola and Stereum hirsutum are the most studied and well documented in Romania. Management measures are quite limited, and they mostly include preventive measures to stop the GTDs spread and the removal of affected grapevines.
Following the global trend of selling high-quality wines, those produced in Blaj vineyard must be superior due to a highly competitive market and consumer tastes and demands. Because the quality of ...wine is given by both sensory and chemical properties this work presents the phenolic fingerprint, the general chemical characteristics, and the sensory properties of the 2021 Blaj Muscat Ottonel wine as well as the phenolic composition of the grapes from which this wine was produced. Grape phenolics were represented by flavanols (73%), flavonols (14%), hydroxybenzoic acids (9.08 %) and hydroxycinnamic acids (4%), while wine phenolics by flavanols (42%), hydroxycinnamic acids (33%) and hydroxybenzoic acids (15%). Catechin and procyanidin dimer B1 were identified both in grapes and in wine. More than half of the grapes’ procyanidin dimer B1 (3.638 mg/g out of 6.379 mg/g) and more than one-tenth of grapes’ catechin (1.570 mg/g out of 9.298 mg/g) were found in wine. As the general and sensory qualities of the Blaj Muscat Ottonel wine were kept within the limits of a Protected Designation of Origin (PDO) demi-sweet wine, the presence of resveratrol glucoside, catechin, and procyanidin in its content supports the idea of classifying this wine as a potential nutraceutical ‘functional wine’.
The present study aimed, on the one hand, to improve the yield of microwave assisted extraction (MAE) of polyphenols from beech bark by using a design of experiments (DoE) approach. On the other ...hand, beech bark extracts (BBE) were characterized in terms of their phytochemical profile and evaluated for biological potential (antioxidant, antibacterial, antifungal, antimutagen, anti-α-glucosidase, and anti-tyrosinase). The extraction time varies with the amount of extracted total phenolic content (TPC). The microwave power favors TPC extraction but in different proportions. The optimum conditions which gave the highest TPC (76.57 mg GAE/g dry plant material) were reached when the microwave power was 300 W, extraction time was 4 min, and the solvent was an ethanol–water (50:50) mixture. The practical value of TPC after a controlled experiment was 76.49 mg GAE/g plant material. The identified compounds were vanillic acid, gallic acid, epicatechin, catechin, protocatechuic acid, chlorogenic acid, ferulic acid, and isoquercitrin. The antioxidant potential of BBEs was demonstrated by in vitro experiments. The BBEs were active against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, and Candida species. All extracts were antimutagenic and expressed an inhibition on α-glucosidase and tyrosinase activity. Regarding antimutagen activity, the assayed extracts may be considered to have low or no antimutagen effects.
Plasma protein binding plays a critical role in drug therapy, being a key part in the characterization of any compound. Among other methods, this process is largely studied by ultrafiltration based ...on its advantages. However, the method also has some limitations that could negatively influence the experimental results. The aim of this study was to underline key aspects regarding the limitations of the ultrafiltration method, and the potential ways to overcome them. The main limitations are given by the non-specific binding of the substances, the effect of the volume ratio obtained, and the need of a rigorous control of the experimental conditions, especially pH and temperature. This review presents a variety of methods that can hypothetically reduce the limitations, and concludes that ultrafiltration remains a reliable method for the study of protein binding. However, the methodology of the study should be carefully chosen.
Knowledge about the geographical areas preferred by grapevine moths, the size of the populations, and the attraction to certain cultivars supports winegrowers for a better zoning of vineyards and ...vine cultivars, which is in continuing dynamic due to the climate change. Grapevine moths Lobesia botrana (Denis & Schiffermüller) and Eupoecilia ambiguella (Hübner) are the main pests of grapes in the Târnave vineyard. For this reason, the influence of the cultivar in the climatic conditions of 2016-2019 period on the dynamics of the two moths species was evaluated in five plantations (Jidvei, Șona, Sâmniclăuș, Tăuni and Cenade) from Târnave vineyards on five cultivars Fetească regală, Sauvignon blanc, Chardonnay, Traminer and Rhine Riesling. During the studied period, the climate experienced deviations from the multiannual values. Our results highlight different activities of the two moth species. The number of captures was influenced by climatic conditions, geographical area and grape cultivar. L. botrana prefers drier climates, lower geographical areas and Traminer cultivar; meanwhile, E. ambiguella prefers wetter climates, higher hilly areas and the Sauvignon blanc cultivar. These findings are important in the general context of grapevine protection in order to reduce the use of pesticides by choosing the right cultivars in the appropriate climate conditions.
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