The aim of this study was, first of all, to associate the mercury (Hg) concentrations and respiratory functions of the gold miners in the artisanal small-scale gold mining (ASGM) environment in San ...Martín de Loba, Colombia. We carried out a cross-sectional study using a survey whereby we collected basic demographic information, occupational medical history, and applied two validated questionnaires (Q16 and SF36). We measured Hg levels in all volunteers using direct thermal decomposition-atomic absorption spectrometry. Univariate and bivariate statistical analyses were carried out for all variables, performing logistic regression to assess the effect of ASGM on health outcomes. Volunteers enrolled (n = 124) were between the ages of 20 and 84 years (84% miners and 79% males). No changes were found in the systolic blood pressure, diastolic blood pressure, and heart rate from the ASGM miners, in crude and adjusted statistical analyses. ASGM miners increased 8.91 (95% confidence interval, 1.55-95.70) times the risk of having these than of having neurotoxic effects. Concentrations of total whole blood mercury (T-Hg) in all participants ranged from 0.6 to 82.5 with a median of 6.0 μg/L. Miners had higher T-Hg concentrations than non-miners (
-value = 0.011). Normal and abnormal respiratory spirometry patterns showed significant differences with the physical role and physical function of quality-of-life scales (the (
-value was 0.012 and 0.004, respectively). The spirometry test was carried out in 87 male miners, with 25% of these miners reporting abnormalities. Out of these, 73% presented a restrictive spirometry pattern, and 27%, an obstructive spirometry pattern. The ASGM population had higher Hg concentrations and worse neurotoxic symptomatology than non-miners of the same community.
The aim of the present study was to find if workers chronically exposed to lead (Pb) and cadmium (Cd) presented changes in their general health and in the clinical parameters of the population under ...study. We carried out a cross-sectional survey in a sample of informal workers in Cartagena, Colombia. The population under study was composed of male informal workers (≥18 years of age), with experience in their job, selected from occupational settings with potential exposure to Pb and Cd (i.e., mechanics, battery and garbage recyclers, and welders). The median age was 45 years (interquartile range (IQR), 33−53). The median blood Pb level (BLL) was 2 μg/dL (IQR, 0.76−6.22), and the median of blood Cd level (BCL) was 1.22 μg/L (IQR, 0.33−2.01). The study found that 33% of high exposure jobs with BLL > 5 μg/dL (n = 57), whereas in ‘control’ workers, this was 15.3% (n = 9). The highest BLLs were found in battery recyclers (82.1%; n = 23), followed by mechanics (37.3%, n = 22). In the logistic regression model adjusted by age, time on the job, smoking and elevated BCL and BLL increased 3.2 times (95% CI, 1.1−9.7) in mechanics and 29.6 times (95% CI, 7.2−145.6) in battery recyclers. This study found negative changes in the health of workers with higher chronic exposure to lead in Cartagena, Colombia.
The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause ...lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19. Concomitantly with occurrence of cell death and inflammation, FasL expression was significantly increased on inflammatory monocytic macrophages and NK cells in the lungs of MA20-infected mice. Importantly, therapeutic FasL inhibition markedly increased survival of both, young and old MA20-infected mice coincident with substantially reduced cell death and inflammation in their lungs. Intriguingly, FasL was also increased in the bronchoalveolar lavage fluid of critically-ill COVID-19 patients. Together, these results identify FasL as a crucial host factor driving the immuno-pathology that underlies COVID-19 severity and lethality, and imply that patients with severe COVID-19 may significantly benefit from therapeutic inhibition of FasL.
The X-ray crystallographic structures, the magnetic susceptibilities from 2 to 300 K, and a theoretical analysis of the magnetism for a triangular and a tetranuclear molecule consisting of linked ...high-spin cobalt(II) centers are described. The interpretation of the magnetic data for the triangular compound Co(depa)Cl3 (depa is the anion of 2,2‘-(bis-4-ethylpyridyl)amine), which has tetrahedrally coordinated Co2+ ions, entails isotropic antiferromagnetic exchange interaction and antisymmetric exchange acting within the two low-lying spin doublets. Two strong isotropic ferromagnetic interactions have been modeled in the cuboidal compound Co4(DPM)4(CH3O)4(CH3OH)4 (DPM represents the anion of dipivaloylmethane), which has octahedral coordination, and the system can be approximately considered as two weakly coupled S = 3 species.
Intraepithelial cervical lesions in indigenous in Ecuador Zoila Katherine Salazar Torres; Magdali del Rocío Murillo Bacilio; Boris Santiago Castro Reyes ...
DOAJ (DOAJ: Directory of Open Access Journals),
12/2019, Letnik:
47, Številka:
2
Journal Article
Recenzirano
Odprti dostop
The aim of this research was to determine the prevalence of cervical intraepithelial lesions in indigenous women of Ecuador 2017. A descriptive study was performed. Population was formed by 2489 ...indigenous women aged 15 to 64 years old, of which 396 users were chosen by spontaneous demand. Frequency values and percentages were taken from qualitative variables, while mean and standard deviation were taken from quantitative variables. Prevalence of intraepithelial lesions was 13,8%. Average age was 31 years old. Uncertain importance's squamous atypical cells were higher in 30-to-39-year-old group (46,7%). Non-specific atypical glandular cells were observed in 66,7% of 30-to-39-year-old group. Low-grade intraepithelial lesions were majorly found in 20-to-29-year-old group (43,8%). High-grade intraepithelial lesions were also seen in 20-to-29-year-old group. Conclusions were: prevalence of intraepithelial lesions in indigenous women of Ecuador was higher than 10% of reported in other studies, and more frequent in those aged 20 and 39 years old.
The aim of this research was to determine the prevalence of cervical intraepithelial lesions in indigenous women of Ecuador 2017. A descriptive study was performed. Population was formed by 2489 ...indigenous women aged 15 to 64 years old, of which 396 users were chosen by spontaneous demand. Frequency values and percentages were taken from qualitative variables, while mean and standard deviation were taken from quantitative variables. Prevalence of intraepithelial lesions was 13,8%. Average age was 31 years old. Uncertain importance's squamous atypical cells were higher in 30-to-39-year-old group (46,7%). Non-specific atypical glandular cells were observed in 66,7% of 30-to-39-year-old group. Low-grade intraepithelial lesions were majorly found in 20-to-29-year-old group (43,8%). High-grade intraepithelial lesions were also seen in 20-to-29-year-old group. Conclusions were: prevalence of intraepithelial lesions in indigenous women of Ecuador was higher than 10% of reported in other studies, and more frequent in those aged 20 and 39 years old. Keywords: Uterine cervical dysplasia, cervix neoplasms, intraepithelial cervical neoplasm El objetivo de esta investigación fue determinar la prevalencia de lesiones intraepiteliales cervicales en mujeres indígenas del Ecuador 2017. Se realizó un estudio descriptivo. La población estuvo compuesta por 2489 mujeres indígenas de 15 a 64 años, de las cuales 396 usuarias fueron elegidas por demanda espontánea. De las variables cualitativas se obtuvieron los valores de frecuencia y porcentajes, y de las cuantitativas la media y la desviación estándar. La prevalencia de las lesiones intraepiteliales fue del 13,8%. La edad promedio fue 31 años. Las células escamosas atípicas de importancia incierta fueron mayores en el grupo de edad de 30 a 39 años (46,7%). Se observaron células atípicas glandulares no específicas en el 66,7% en el grupo de 30 y 39 años de edad. Las lesiones intraepiteliales de bajo grado se presentaron más en el grupo de 20 y 29 años (43,8%). Las lesiones intraepiteliales de alto grado se identificaron también en el grupo de 20 a 29 años de edad. Las conclusiones fueron: la prevalencia de lesiones intraepiteliales en las mujeres indígenas del Ecuador fue superior al 10% de las reportadas en otros estudios, y más frecuente en aquellas de 20 y 39 años de edad. Palabras clave: displasia cervical uterina, neoplasias del cuello uterino, neoplasia intraepitelial cervical.
Les enjeux des 26èmes journées du longitudinal (JDL) étaient d’examiner les formes de la sélection, ainsi que leurs évolutions et leurs articulations, d’interroger l’expérience de celles et de ceux ...qui sont sélectionnés et de celles et de ceux qui sélectionnent et de distinguer les ressemblances et les dissemblances entre les deux univers scolaire et professionnel. L’approche longitudinale requise pour ces journées a permis d’analyser les sélections successives au fil des parcours, dans le système éducatif puis vers et sur le marché du travail, ceci notamment en examinant les déterminants qui conduisent à accéder ou non à telle ou telle position dans le système éducatif (niveau, filière, spécialité, etc.) ou sur le marché du travail (qualification, secteur, etc.). À cette fin, les contributions se sont appuyées sur des méthodes quantitatives, via des enquêtes nationales ou locales, ou qualitatives, par des entretiens biographiques et/ou des interrogations répétées. Ces journées ont été organisées par le centre associé au Céreq de Toulouse du Laboratoire CERTOP (UMR-CNRS et Université Jean-Jaurès), avec la participation des laboratoires EFTS (UMR Université Jean-Jaurès et ENSFEA) et LPS-DT (EA Université Jean-Jaurès). Elles se sont déroulées en visioconférences, les 12 et 13 novembre 2020, et ont bénéficié du soutien financier de l’Université Jean-Jaurès Toulouse 2, de l’Institut national de la jeunesse et de l’éducation populaire (INJEP), du Céreq et des trois laboratoires organisateurs. Depuis plus de 20 ans, les JDL sont organisées par le Céreq ou un de ses centres régionaux associés. Elles regroupent une centaine de chercheur·e·s autour d’une thématique inscrite dans une approche longitudinale de l’analyse de la relation formation-emploi. Les actes des rencontres sont édités tous les ans par le Céreq.
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing ...host immunity. Molecular arms-races have been a strong driving force for the evolution of pathogenicity, with pathogens often encoding overlapping or redundant functions, such as type III protein secretion effectors and hosts encoding ever more sophisticated immune systems. The pathogens' frequent exposure to other microbes, either in their host or in the environment, provides opportunities for the acquisition or interchange of mobile genetic elements. These DNA elements accessorise the core genome and can play major roles in shaping genome structure and altering the complement of virulence factors. Here, we review the different mobile genetic elements focusing on the more recent discoveries and highlighting their role in shaping bacterial pathogen evolution.
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