Estrogens and the skin Brincat, MP; Muscat Baron, Y; Galea, R
Climacteric : the journal of the International Menopause Society,
06/2005, Letnik:
8, Številka:
2
Journal Article
Recenzirano
Objective A review of the medical literature concerning the effect of the menopause and its hormonal treatment on the skin.
Methods An extensive Medline and Pubmed internet search utilizing the key ...words: collagen, elastin, estrogen, hormone replacement therapy, skin and aging.
Results The literature review demonstrated a wide array of research ranging from basic science work to clinical implications of the effects of the menopause and its treatment on the skin.
Conclusion Estrogen loss at menopause has a profound influence on skin. Estrogen treatment in postmenopausal women has been repeatedly shown to increase collagen content, dermal thickness and elasticity, and data on the effect of estrogen on skin water content are also promising. Further, physiologic studies on estrogen and wound healing suggest that hormone replacement therapy (HRT) may play a beneficial role in cutaneous injury repair. Results on the effect of HRT on other physiologic characteristics of skin, such as elastin content, sebaceous secretions, wrinkling and blood flow, are discordant. Given the responsiveness of skin to estrogen, the effects of HRT on aging skin require further examination, and careful molecular studies will likely clarify estrogen's effects at the cellular level.
Objective To assess the intervertebral disc height in postmenopausal women with osteoporotic vertebral fractures.
Methods A total of 203 women were recruited from a bone densitometer directory. The ...disc heights measured were those between the 12th thoracic and 3rd lumbar vertebrae. The discs were assigned the symbols D, whereby D1 refers to the disc between the 12th thoracic and 1st lumbar vertebrae. The disc height of the group of women (n = 38) with osteoporotic vertebral fractures was compared to the disc heights of hormone-treated women (n = 47), untreated postmenopausal women (n = 77) and another group of premenopausal women (n = 41).
Results The total disc height (D1 - D3) (mean ± standard deviation) in the fracture group was 1.58 ± 0.1 cm, significantly lower (p < 0.0001) than in the untreated group (1.82 ± 0.06 cm), which in turn was significantly (p < 0.0001) lower than in the hormone-treated group (2.15 ± 0.08 cm) and in the premenopausal group (2.01 ± 0.09 cm).
Conclusion The fracture group was noted to have the lowest intervertebral disc height compared to the other three groups. The hormone-treated and the premenopausal women had the highest disc heights recorded. These results may be due to the effect that the menopause and senescence have on the discal connective tissue components. This may lead to loss of the shock-absorbing properties of the intervertebral disc and an altered discoid shape, influencing the occurrence of osteoporotic vertebral body fractures.
430 Labour ward: delivery suite or admissions unit? Vella Brincat, D.; Abu Shamala, N.; Cordina, C. ...
European journal of obstetrics & gynecology and reproductive biology,
March 2022, 2022-03-00, Letnik:
270
Journal Article
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