The inclusion of heavy neutral leptons (right-handed neutrinos) to the Standard Model (SM) particle content is one of the best motivated ways to account for the observed neutrino masses and flavor ...mixing. The modification of the charged and neutral currents from active-sterile mixing of the neutral leptons can provide novel signatures which can be tested at the future collider experiments. In this article, we explore the discovery prospect of a very heavy right handed neutrino to probe such extensions at the future collider experiments like Large Hadron electron Collider (LHeC) and linear collider. We consider the production of the heavy neutrino via the t and s-channel processes and its subsequent decays into the semileptonic final states. We specifically focus on the scenario where the gauge boson produced from heavy neutrino decay is highly boosted, leading to a fat jet. We study the bounds on the sterile neutrino properties from several past experiments and compare with our results.
We propose a simple extension of the Standard Model (SM) which has a viable dark matter (DM) candidate and can explain the generation of tiny neutrino masses. The DM is an electroweak (EW) singlet ...scalar S, odd under an imposed exact Z2 symmetry, that interacts with the SM through the “Higgs portal” coupling, while all other particles are even under Z2. The model also has an EW isospin 3/2 scalar Δ and a pair of EW isospin vectors Σ and Σ¯, which are responsible for generating tiny neutrino mass via the effective dimension-seven operator. Thanks to the additional interactions with Δ, the scalar singlet DM S survives a large region of parameter space by relic density constraints from WMAP/Planck and direct search bounds from updated LUX data. Constraints on the model from the LHC are also discussed.
Photoionization in the time and frequency domain Isinger, M.; Squibb, R. J.; Busto, D. ...
Science (American Association for the Advancement of Science),
11/2017, Letnik:
358, Številka:
6365
Journal Article
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Ultrafast processes in matter, such as the electron emission after light absorption, can now be studied using ultrashort light pulses of attosecond duration (10−18 seconds) in the extreme ultraviolet ...spectral range. The lack of spectral resolution due to the use of short light pulses has raised issues in the interpretation of the experimental results and the comparison with theoretical calculations. We determine photoionization time delays in neon atoms over a 40–electron volt energy range with an interferometric technique combining high temporal and spectral resolution. We spectrally disentangle direct ionization from ionization with shake-up, in which a second electron is left in an excited state, and obtain excellent agreement with theoretical calculations, thereby solving a puzzle raised by 7-year-old measurements.
In this paper, we revisit the dimension-7 neutrino mass generation mechanism based on the addition of an isospin 3/2 scalar quadruplet and two vectorlike isotriplet leptons to the standard model. We ...discuss the LHC phenomenology of the charged scalars of this model, complemented by the electroweak precision and lepton flavor violation constraints. We pay particular attention to the triply charged and doubly charged components. We focus on the same-sign-trilepton signatures originating from the triply charged scalars and find a discovery reach of 600–950 GeV at 3 ab−1 of integrated luminosity at the LHC. On the other hand, doubly charged Higgs has been an object of collider searches for a long time, and we show how the present bounds on its mass depend on the particle spectrum of the theory. Strong constraints on the model parameter space can arise from the measured decay rate of the standard model Higgs to a pair of photons as well.
Abstract
The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of a drug and/or ...component, equipment, their toxicological studies, dose, side effects are in vivo studied for future use in humans considering its’ ethical issues. Here lies the importance of the animal model for its enormous use in biomedical research. Animal models have many facets that mimic various disease conditions in humans like systemic autoimmune diseases, rheumatoid arthritis, epilepsy, Alzheimer’s disease, cardiovascular diseases, Atherosclerosis, diabetes, etc., and many more. Besides, the model has tremendous importance in drug development, development of medical devices, tissue engineering, wound healing, and bone and cartilage regeneration studies, as a model in vascular surgeries as well as the model for vertebral disc regeneration surgery. Though, all the models have some advantages as well as challenges, but, present review has emphasized the importance of various small and large animal models in pharmaceutical drug development, transgenic animal models, models for medical device developments, studies for various human diseases, bone and cartilage regeneration model, diabetic and burn wound model as well as surgical models like vascular surgeries and surgeries for intervertebral disc degeneration considering all the ethical issues of that specific animal model. Despite, the process of using the animal model has facilitated researchers to carry out the researches that would have been impossible to accomplish in human considering the ethical prohibitions.
Recently, research has picked up a fervent pace in the area of fault diagnosis of electrical machines. The manufacturers and users of these drives are now keen to include diagnostic features in the ...software to improve salability and reliability. Apart from locating specific harmonic components in the line current (popularly known as motor current signature analysis), other signals, such as speed, torque, noise, vibration etc., are also explored for their frequency contents. Sometimes, altogether different techniques, such as thermal measurements, chemical analysis, etc., are also employed to find out the nature and the degree of the fault. In addition, human involvement in the actual fault detection decision making is slowly being replaced by automated tools, such as expert systems, neural networks, fuzzy-logic-based systems; to name a few. It is indeed evident that this area is vast in scope. Hence, keeping in mind the need for future research, a review paper describing different types of faults and the signatures they generate and their diagnostics' schemes will not be entirely out of place. In particular, such a review helps to avoid repetition of past work and gives a bird's eye view to a new researcher in this area.
The discovery of a significantly large anomalous Hall effect in the chiral antiferromagnetic system—Mn3Ge—indicates that the Weyl points are widely separated in phase space and positioned near the ...Fermi surface. In order to examine the effects of Fe substitution in Mn3Ge on the presence and location of the Weyl points, we synthesized (Mn1−αFeα)3Ge (α=0−0.30) compounds. The AHE was observed in compounds up to α = 0.22, but only within the temperature range where the magnetic structure remains the same as the Mn3Ge. Additionally, positive longitudinal magnetoconductance and planar Hall effect (PHE) were detected within the same temperature and doping range. These findings strongly suggest the existence of Weyl points in (Mn1−αFeα)3Ge (α=0−0.22) compounds. Further, we observed that with an increase in Fe doping fraction, there is a significant reduction in the magnitude of anomalous Hall conductivity, PHE, and positive longitudinal magnetoconductance, indicating that the Weyl points move further away from the Fermi surface. Consequently, it can be concluded that suitable dopants in the parent Weyl semimetals have the potential to tune the properties of Weyl points and the resulting anomalous electrical transport effects.
ABSTRACT
We report the complex radio properties of the radio galaxy NGC 2329 that resides in the centre of the galaxy cluster Abell 569. For this study, we have used archival data from the Very Large ...Array (VLA) at various resolutions and frequencies, as well as the Very Long Baseline Array (VLBA). While the wide-angle tailed (WAT) Fanaroff–Riley type I (FR I) radio morphology of the source has been discussed widely in the literature, the nature of the inner lobes has not been as widely discussed. In particular, we note that the inner lobes resemble the bubble-like radio structures observed in Seyfert galaxies. Polarization-sensitive data from the VLA clearly show magnetic field structures consistent with FR Is for the outer lobes and Seyferts for the inner lobes in NGC 2329. FR Is are classified as radio-loud (RL) active galactic nuclei (AGN) and Seyferts as radio-quiet (RQ) AGN, making this source unique. The VLBA shows a one-sided radio jet suggesting a relativistic pc-scale outflow, leading into the inner lobes. Electron lifetime estimates suggest that the outer FR I-like lobes are nearly twice as old (∼45 Myr) as the inner Seyfert-like lobes (∼25 Myr). Gas inflow in this merging cluster seems to have rejuvenated the AGN about ∼25 Myr ago, and may have caused a change in the accretion disc state. The complex composite radio morphology of NGC 2329 suggests that the RL/RQ dichotomy is a function of time in the lifecycle of an AGN.
Increased matrix metalloprotease 9 (MMP9) after myocardial infarction (MI) exacerbates ischemia-induced chronic heart failure (CHF). Autophagy is cardioprotective during CHF; however, whether ...increased MMP9 suppresses autophagic activity in CHF is unknown. This study aimed to determine whether increased MMP9 suppressed autophagic flux and MMP9 inhibition increased autophagic flux in the heart of rats with post-MI CHF. Sprague-Dawley rats underwent either sham surgery or coronary artery ligation 6-8 wk before being treated with MMP9 inhibitor for 7 days, followed by cardiac autophagic flux measurement with lysosomal inhibitor bafilomycin A1. Furthermore, autophagic flux was measured in vitro by treating H9c2 cardiomyocytes with two independent pharmacological MMP9 inhibitors, salvianolic acid B (SalB) and MMP9 inhibitor-I, and CRISPR/cas9-mediated MMP9 genetic ablation. CHF rats showed cardiac infarct, significantly increased left ventricular end-diastolic pressure (LVEDP), and increased MMP9 activity and fibrosis in the peri-infarct areas of left ventricular myocardium. Measurement of the autophagic markers LC3B-II and p62 with lysosomal inhibition showed decreased autophagic flux in the peri-infarct myocardium. Treatment with SalB for 7 days in CHF rats decreased MMP9 activity and cardiac fibrosis but increased autophagic flux in the peri-infarct myocardium. As an in vitro corollary study, measurement of autophagic flux in H9c2 cardiomyocytes and fibroblasts showed that pharmacological inhibition or genetic ablation of MMP9 upregulates autophagic flux. These data are consistent with our observations that MMP9 inhibition upregulates autophagic flux in the heart of rats with CHF. In conclusion, the results in this study suggest that the beneficial outcome of MMP9 inhibition in pathological cardiac remodeling is in part mediated by improved autophagic flux.
This study elucidates that the improved cardiac extracellular matrix (ECM) remodeling and cardioprotective effect of matrix metalloprotease 9 (MMP9) inhibition in chronic heart failure (CHF) are via increased autophagic flux. Autophagy is cardioprotective; however, the mechanism of autophagy suppression in CHF is unknown. We for the first time demonstrated here that increased MMP9 suppressed cardiac autophagy and ablation of MMP9 increased cardiac autophagic flux in CHF rats. Restoring the physiological level of autophagy in the failing heart is a challenge, and our study addressed this challenge. The novelty and highlights of this report are as follows:
) MMP9 regulates cardiomyocyte and fibroblast autophagy,
) MMP9 inhibition protects CHF after myocardial infarction (MI) via increased cardiac autophagic flux,
) MMP9 inhibition increased cardiac autophagy via activation of AMP-activated protein kinase (AMPK)α, Beclin-1, Atg7 pathway and suppressed mechanistic target of rapamycin (mTOR) pathway.
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