•Signals which overlaps in both time and frequency domain, are very difficult to separate out without distortion.•In multimedia content making, sound plays a vital role.•Deep Neural Networks ...(DNN)have been used to handle the full separation of overlapping sources.•DNNs for audio signal separation depends on factors such as the quality, size of the training data, architecture of the network, and the specific task at hand.
Separating the signals from the mixture when the signals share same frequency and time domain pattern is always a matter of concern. In natural environment, sound events often appear simultaneously, increasing the complexity. Movie making and audio-visual content creation is an industry which covers a huge share of our economy. With the advancement of technology, it becomes important to give audience more realistic experience. But sometimes due to certain environmental conditions, recording devices capture sound signals which overlap with the character voice of the script or required ambience sound either in frequency domain or time domain or in both. To fix the problem, sound engineers mostly dub the sound in the studio and try to collect the ambience sound later on. Further mixing is done during post processing of sound. Although different software tools are available in market, but here aesthetic value and originality of the sound has been compromised. Because, it is very hard to get the exact voice parameters and same ambience in studio environment. This paper gives an overview of different approaches to deal with the overlapping sound by focussing the recently reported literature and highlights the key attributes which are catalysing the evolving scenario.
Noise removal continuous to be a challenging domain of work despite of several techniques which are proposed to overcome this issue are found to be efficient and reliable. In mobile communications, ...the time varying nature of signals and noise makes this issue more challenging. Among conventional signal processing techniques, finite impulse response (FIR) and infinite impulse response (IIR) structures provide their own set of advantages and disadvantages. Though gamma filters in FIR and IIR forms have been suggested for noise cancellation in speech, it is bottlenecked due to issue such as longer convergence time, delay generation and inability to provide phase variation compensation. This paper presents certain techniques to overcome this issue. Firstly, a modified gamma filter with a feedback structure is used to improve MSE convergence and provide better phase variation correction. The second method uses a transfer function approach for phase correction of the filtered signal. Experiments show that the MSE and phase difference(in degree) between the filtered signal and the desired signal are lower for the proposed structure than the MSE and phase difference values obtained for the FIR filter and original gamma filter structure. Thus the suggested techniques have been found to be more reliable and efficient.
In recent years research based on kaempferol (KMP) has shown its potential therapeutic applications in medicinal chemistry and clinical biology. Therefore, to understand its molecular recognition ...mechanism, we studied its interactions with the carrier proteins, namely, human serum albumin (HSA), bovine hemoglobin (BHb) and hen egg white lysozyme (HEWL). The ligand, KMP was able to quench the intrinsic fluorescence of these three proteins efficiently through static quenching mode. The binding constant (Kb) for the interactions of KMP with these three proteins were found in the following order: HSA-KMP > BHb-KMP > HEWL-KMP. Different non-covalent forces such as hydrogen bonding and hydrophobic forces played a major role in the binding of KMP with HSA and HEWL, whereas hydrogen bonding and van der Waals forces contribute to the complexation of BHb with KMP. KMP was able to alter the micro-environment near the Trp fluorophore of the proteins. KMP altered the secondary structural component of all three proteins. The putative binding sites and the residues surrounding the KMP molecule within the respective protein matrix were determined through molecular docking and molecular dynamics (MD) simulation studies. The conformational flexibility of the ligand KMP and the three individual proteins were also evident from the MD simulation studies.
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•Kaempferol (KMP) quenched the intrinsic fluorescence of HSA, BHb, and HEWL.•Non-covalent forces played significant roles in the complexation processes.•Micro-environment around the tryptophan of the proteins altered on complexation with KMP.•The alterations in the α-helical content of HEWL and BHb was observed on binding with KMP.•Docking and MD simulation studies indicate the preferred binding locations of KMP within the proteins.
Introduction: The detection of inflammation is important for diagnosis of inflammatory joint diseases and its severity. There are clinically doubtful cases of inflammation of joints. Advanced thermal ...cameras are able to detect the presence of inflammation. Hence, thermal imaging technology has been used for detection of this type of subclinical inflammation of joints. Aim: To study the efficacy of infrared imaging to detect the subclinical inflammation of joints in doubtful cases of arthritis. Materials and Methods: A prospective cohort study was conducted for a period of one year from January 2016 to June 2017. The study comprised of 60 patients of all age groups. Patients with joint pain attending Out Patient Department (OPD) of Physical Medicine and Rehabilitation Department (PMR), Agartala Government Medical College (AGMC) and Govind Ballav Pant Hospital (GBPH), Agartala, India, irrespective of the duration of illness and diseases were selected considering inclusion and exclusion criteria. They were evaluated clinically (swelling, tenderness, redness, increased temperature and the presence of restriction of movement) for presence of inflammation in the joint. Blood tests were done for Acute Phase Reactant (APR) namely Erythrocyte Sedimentation Rate (ESR) and C-reactive Protein (CRP) and infrared imaging of the respective joints were taken. On the basis of clinical examination all these patients were divided in three groups: (i) patients with inflamed joint; (ii) non inflamed joint; and (iii) doubtful inflammation of joints. Infrared imaging of all the respective joints of all the patients were compared with the respective results of APR for presence of inflammation. Values more than the normal range of APR were considered as positive marker for inflammation. The data was analysed statistically by calculating sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) using MATLAB 2013b software. Results: Out of 60 cases, 37 (61.66%) patients showed clinically inflamed joints, 10 (16.66%) showed no inflammation and there were 13 (21.66%) clinically doubtful cases of inflammation. The results were statistically analysed and the sensitivity, specificity, PPV and NPV of infrared imaging for detection of joint inflammation were 91%, 80%, 94% and 72%, respectively. Conclusion: Infrared imaging is a very sensitive tool for the detection of inflammation of joints and is very useful for detection of subclinical inflammation of joint.
In order to better understand the bioavailability and biocompatibility of polyphenol-assisted surface-modified bioengineered nanoparticles in nanomedicine applications, here, we address a series of ...photophysical experiments to quantify the binding affinity of serum albumin toward polyphenol-capped gold nanoparticles. For this, two different gold nanoparticles (AuNPs) were synthesized via the green synthesis approach, where curcumin and turmeric extract act as reducing as well as capping agents. The size, surface charge, and surface plasmon bands of the AuNPs were highly affected by the adsorption of human serum albumin (HSA) during protein corona formation, which was investigated using dynamic light scattering (DLS), ξ-potential, ultraviolet–visible (UV–vis) spectroscopy, and transmission electron microscopy (TEM) measurements. Fluorescence-based methods, absorbance, and SERS experiments were carried out to evaluate the binding aspects of AuNPs with HSA. We found that the AuNPs show moderate binding affinity toward HSA (K b ∼ 104 M–1), irrespective of the capping agents on the surface. Hydrophobic association, along with some contribution of electrostatic interaction, played a key role in the binding process. The binding interaction was more toward the subdomain IIA region of HSA, as indicated by the competitive displacement studies using site-specific binders (warfarin and flufenamic acid). Because of the large surface curvature of small-sized AuNPs, the secondary structural conformations of HSA were slightly altered, as revealed by circular dichroism (CD), Fourier transform infrared (FT-IR) spectroscopy, and surface-enhanced Raman scattering (SERS) measurements. Additionally, the findings of the binding interactions were re-evaluated using molecular dynamics (MD) simulation studies by determining the root-mean-square deviation (RMSD), root-mean-square fluctuation (RMSF), radius of gyration (R g), and changes in the binding energy of HSA upon complexation with AuNPs. To determine the tentative evidence for pharmacokinetic administration, these biocompatible AuNPs were applied to inhibit the amyloid fibril formation of HSA and monitored by using the thioflavin T (ThT) assay, ANS fluorescence assay, fluorescence microscopic imaging, and FESEM. AuNPs were found to show better resistance toward fibrillation of the adsorbed protein.
•We examine the economy-wide impact of the CEPA between India and Japan through economic and CGE analysis;.•Tariff reductions will create a marginal increase in output growth for both ...countries;.•India's exports to Japan would increase more than those of Japan to India;.•Positive net welfare gains are expected for both countries as a result of trade liberalization;.•Japan will not reduce its heavy reliance on the Chinese market, though India will. In general, India, compared to Japan, will gain more if CEPA materializes by 2020;.•Both countries need to accelerate structural reforms to remove behind the border barriers in addition to reducing tariffs, in order to reap maximum benefit of their economic partnership.
This paper examines the benefits and challenges of the 2011 Comprehensive Economic Partnership Agreement (CEPA) between India and Japan, specifically the ways to maximize gains from their complementary economies, trade and FDI relations. It also measures the partnership's economy-wide impact empirically, and its role in regional and global integration. An analysis of the trade intensity indices shows that the bilateral trade flow is small considering the other country's importance in world trade, suggesting the existence of great potential for improving trade relations. The computable general equilibrium (CGE) analysis of the economy wide impact of the CEPA suggests that tariff reductions will create a marginal increase in output growth for both India and Japan as compared to the business as usual scenario. In terms of the effect on exports, India's exports to Japan would increase more than those of Japan to India while positive net welfare gains are expected for both countries as a result of trade liberalization. This is in contrast to the study by Ahmed (2010), which finds welfare gains only for Japan, not for India. Furthermore, one of the striking results of the paper is that Japan will not reduce its heavy reliance on the Chinese market, though India will. In general, India, compared to Japan, will gain more, if CEPA materializes by 2020. Japan too will have welfare gains in spite of opening up the agriculture sector with 100% tariff reduction by 2020. Both countries need to accelerate structural reforms to remove the border barriers in addition to reducing tariffs, in order to reap maximum benefit of their economic partnership.
... we have undertaken this study. ... overall, the right hand was found to be affected more commonly. The occupation of many patients (as well as household work, especially in women) makes their ...hands and feet vulnerable to repeated minor trauma and exposure to water, chemicals and irritants for relatively long periods.
Nail changes and nail disorders in the elderly Rao, Sudhakar; Banerjee, Sabyasachi; Ghosh, Sadhan Kumar ...
Indian journal of dermatology,
07/2010, Letnik:
55, Številka:
3
Journal Article
Recenzirano
Odprti dostop
The right thumb, index, and ring fingers were affected in four cases each, the left thumb and the right middle finger in three cases while the left index, middle, ring and little fingers, right ...little finger and left toe were involved in two cases each. ... the right hand was found to be more commonly affected. ... dermatologists will have to brace themselves up beforehand to handle such common geriatric problems of this organ.
In Arthritis, the self-limiting inflammatory process becomes continuous and as a result chronic inflammatory disease might occur. The skin surface is responsible for maintaining the core internal ...body temperature. Medical Infrared thermography (MIT) as a diagnostic tool is well known for its contribution in providing statistical quantification to detect acute to minute temperature deviation for accurate assessment of inflammation. Accurate assessment of inflammation helps in making early individual treatment plan and also offers an insight to the determination of severity of the disease. In this scope, we validate the importance of infrared imaging with a newly created datasets of Arthritis knee joints. After validation, the efficacy of infrared imaging is also proved as a complementary diagnostic tool to other clinical tests in detecting inflammation that lacks recognizable clinical findings in relation to Arthritis.
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