The next generation of water Cherenkov neutrino telescopes in the Mediterranean Sea are under construction offshore France (KM3NeT/ORCA) and Sicily (KM3NeT/ARCA). The KM3NeT/ORCA detector features an ...energy detection threshold which allows to collect atmospheric neutrinos to study flavour oscillation. This paper reports the KM3NeT/ORCA sensitivity to this phenomenon. The event reconstruction, selection and classification are described. The sensitivity to determine the neutrino mass ordering was evaluated and found to be 4.4 \(\sigma\) if the true ordering is normal and 2.3 \(\sigma\) if inverted, after three years of data taking. The precision to measure \(\Delta m^2_{32}\) and \(\theta_{23}\) were also estimated and found to be \(85\cdot10^{-6}\) eV\(^2\) and \((^{+1.9}_{-3.1})^{\circ}\) for normal neutrino mass ordering and, \(75\cdot10^{-6}\) eV\(^2\) and \((^{+2.0}_{-7.0})^{\circ}\) for inverted ordering. Finally, a unitarity test of the leptonic mixing matrix by measuring the rate of tau neutrinos is described. Three years of data taking were found to be sufficient to exclude \(\nu_{\tau}\) and \(\bar{\nu}_{\tau}\) event rate variations larger than 20% at \(3\sigma\) level.
The cardiac response to a rapid volume infusion was studied in 18 patients with septic shock accompanied by pulmonary hypertension. Right and left ventricular ejection fractions were measured, and ...right and left ventricular volume indices were calculated from ejection fractions and stroke volumes before and 30 minutes after the start of the infusion. Responders (13 patients) showed an increase in stroke volume index (SVI) as a result of a mean 30% increase in right ventricular end-diastolic volume index (RVEDVI) and a mean 17% increase in left ventricular end-diastolic volume index (LVEDVI) during volume loading. In the nonresponders (five patients) fluid loading resulted in a decreased or unchanged SVI; this was accompanied by a 7% increase in RVEDVI but no change in LVEDVI, although both the central venous pressure and pulmonary capillary wedge pressure increased. At baseline, nonresponders differed from responders as evidenced by a high central venous pressure and RVEDVI but a lower mean arterial pressure: thus, right ventricular coronary perfusion pressure was lower and right ventricular wall stress may have been higher. Mean pulmonary artery pressure did not differ between the groups. Our data suggest that in some patients with septic shock volume loading does not result in increased forward flow because of right ventricular failure associated with pulmonary hypertension and coronary hypotension.
The effects of environmental impact assessment in the Netherlands Heuvelhof, E.T; Nauta, C. (Department of Systems Engineering, Policy Analysis and Management, Delft University of Technology, Jaffalaan 5, 2628 BX, Delft (Netherlands))
Project Appraisal (United Kingdom),
(1997), Letnik:
12, Številka:
1
Publication
A double-blind randomized crossover study was performed in 56 chemotherapy-naive patients, all receiving non-cisplatin-based chemotherapy, to compare the antiemetic effects of 2 doses of a single ...administration of methylprednisolone succinate (Solu-Medrol): 250 versus 500 mg. Among the 39 patients who satisfactorily completed both parts of the study, complete and major protection from emesis (0 and 1 emetic episode or only retching) was observed in 79% during the first course and in 69% during the second course. Treatment failure (> or = 6 episodes of vomiting) was observed in 18% during the first course and 21% during the second course. There was no significant difference between the two dose levels neither in terms of antiemetic protection nor in terms of the occurrence of side effects nor in patient preference. Most important side effects were facial flushing (45%), headache (22%) and facial edema (18%). It is concluded that, although a comparison with lower dosages cannot be made, within the dose range studied no clear dose-response relationship could be found.
A young woman presented with a large pancreatic mass that was found to be a solid and papillary epithelial neoplasm. The endoscopic, radiologic, and gross appearance of this tumor is described. The ...origin of the tumor is probably from a multipotential stem cell of the pancreas. Surgical resection is usually curative, although radiotherapy and chemotherapy have been successfully used. This unusual tumor should be considered in the differential diagnosis of a young female with a pancreatic mass.
The first gamma-ray burst detections by Imaging Atmospheric Cherenkov Telescopes have been recently announced: GRB 190114C, detected by MAGIC, GRB 180720B and GRB 190829A, observed by H.E.S.S. A ...dedicated search for neutrinos in space and time coincidence with the gamma-ray emission observed by IACTs has been performed using ANTARES data. The search covers both the prompt and afterglow phases, yielding no neutrinos in coincidence with the three GRBs studied. Upper limits on the energetics of the neutrino emission are inferred. The resulting upper limits are several orders of magnitude above the observed gamma-ray emission, and they do not allow to constrain the available models.
An offline search for a neutrino counterpart to gravitational-wave (GW) events detected during the second observation run (O2) of Advanced-LIGO and Advanced-Virgo performed with ANTARES data is ...presented. In addition to the search for long tracks induced by \(\nu_\mu\) (\(\bar{\nu}_{\mu}\)) charged current interactions, a search for showering events induced by interactions of neutrinos of any flavour is conducted. The severe spatial and time coincidence provided by the gravitational-wave alert allows regions above the detector horizon to be probed, extending the ANTARES sensitivity over the entire sky. The results of this all-neutrino-flavour and all-sky time dependent analysis are presented. The search for prompt neutrino emission within \(\pm\)500~s around the time of six GW events yields no neutrino counterparts. Upper limits on the neutrino spectral fluence and constraints on the isotropic radiated energy are set for each GW event analysed.
This letter presents a combined measurement of the energy spectra of
atmospheric $\nu_e$ and $\nu_\mu$ in the energy range between $\sim$100 GeV and
$\sim$50 TeV with the ANTARES neutrino telescope. ...The analysis uses 3012 days
of detector livetime in the period 2007--2017, and selects 1016 neutrinos
interacting in (or close to) the instrumented volume of the detector, yielding
shower-like events (mainly from $\nu_e+\overline \nu_e$ charged current plus
all neutrino neutral current interactions) and starting track events (mainly
from $\nu_\mu + \overline \nu_\mu$ charged current interactions). The
contamination by atmospheric muons in the final sample is suppressed at the
level of a few per mill by different steps in the selection analysis, including
a Boosted Decision Tree classifier. The distribution of reconstructed events is
unfolded in terms of electron and muon neutrino fluxes. The derived energy
spectra are compared with previous measurements that, above 100 GeV, are
limited to experiments in polar ice and, for $\nu_\mu$, to Super-Kamiokande.
The unique sensitivity of magnetic resonance imaging (MRI) in detecting disease activity in multiple sclerosis (MS) and the objective nature of the information obtained suggest that MRI will be a ...useful and reliable way of monitoring treatment trials. There is a need to develop an appropriate database which would provide a standardised means of assessment, not only of MRI, but also of essential clinical information. As part of the program of Concerted Action in Multiple Sclerosis, funded by the Commission of the European Community (CEC), we have developed a database for recording serial brain MRI results. The database consists of core, entry and follow-up sections. Both entry and follow-up parts are subdivided into clinical, MR system and MRI data. We expect that the use of this database will maximise efficiency of MRI monitoring in MS treatment trials, particularly in multicentre studies.
