Abstract
In view of the Training Quality of Undergraduate Majoring in Logistics Management and Engineering, an improved TOPSIS method based on combinatorial weight is proposed to evaluate the ...training quality of undergraduate majoring in logistics management and engineering. Firstly, the paper studies and analyses the related literatures of training quality of undergraduate majoring in logistics management and engineering, and puts forward a set of evaluation of training quality indicator system for the undergraduate majoring in logistics management and engineering. Secondly, the objective weight and subjective weight of each indicator are determined by using the variable coefficient method based on mixed data and the improved AHP method based on triangular fuzzy number, and on this basis, the combined weight of each indicator is calculated by using the maximum method of comprehensive evaluation value. After that, the improved TOPSIS method is used to rank the training quality for undergraduate majoring in logistics management and engineering.
Ferroptosis is a regulated form of necrotic cell death that involves the accumulation of lipid peroxide (LPO) species in an iron‐ and reactive oxygen species (ROS)‐dependent manner. Previous ...investigations have reported that ferroptosis‐based cancer therapy can overcome the limitations of traditional therapeutics targeting the apoptosis pathway. However, it is still challenging to enhance the antitumor efficacy of ferroptosis due to intrinsic cellular regulation. In this study, a ferroptosis‐inducing agent, i.e., chlorin e6 (Ce6)‐conjugated human serum albumin–iridium oxide (HSA‐Ce6‐IrO2, HCIr) nanoclusters, is developed to achieve sonodynamic therapy (SDT)‐triggered ferroptosis‐like cancer cell death. The sonosensitizing role of both Ce6 and IrO2 within the HCIr nanoclusters exhibits highly efficient 1O2 generation capacity upon ultrasound stimulation, which promotes the accumulation of LPO and subsequently induces ferroptosis. Meanwhile, the HCIr can deplete glutathione (GSH) by accelerating Ir (IV)–Ir (III) transition, which further suppresses the activity of glutathione peroxidase 4 (GPX4) to enhance the ferroptosis efficacy. Through in vitro and in vivo experiments, it is demonstrated that HCIr possesses tremendous capacity to reduce the intracellular GSH content, which enhances SDT‐triggered ferroptosis‐like cancer cell death. Thus, an iridium‐nanoclusters‐based ferroptosis‐inducing agent is developed, providing a promising strategy for inducing ferroptosis‐like cancer cell death.
A bioactive HCIr nanocluster is reported for triggering effective ferroptosis‐like cancer cell death via triggering GPX4 inhibition and concurrent dual sonodynamic effect by iridium oxide nanoclusters and chlorin e6 (Ce6). These HCIr nanoclusters hold a great promise as a ferroptosis‐inducing agent for treating intrinsic apoptotic resistance of tumors, and the findings provide a promising strategy for future studies exploring nanoclusters as anticancer agents.
Concerning the discrete stochastic multi-attribute decision making (SMADM) problems in which attribute values are interval neutrosophic numbers and the attribute weight is incompletely known, a novel ...SMADM method based on the cumulative prospect theory (CPT) and generalized Shapley function is proposed. Firstly, the value prospect of each attribute under interval neutrosophic environment is calculated as well as subjective probability weights respectively, and the prospect function values are obtained according to the formulation of prospect function. Then, following the maximum deviation principle, the optimization model with respect to the incompletely known attribute weight information is constructed to obtain the optimal fuzzy measure, and the optimal weights of each attribute based on the formulation of generalized Shapley function are generated. Further, by aggregating the above prospect function values and the optimal weights, the values of the comprehensive prospect function are obtained and then alternatives are ranked. Finally, an illustrate example is presented to demonstrate the validity and feasibility of the proposed method.
Ferroptosis‐based treatment strategies display the potential to suppress some malignant tumors with intrinsic apoptosis resistance. However, current related cancer treatments are still hampered by ...insufficient intracellular reactive oxygen species (ROS) levels and Fe2+ contents, posing considerable challenges for their clinical translation. Herein, an intracellular acid‐biodegradable iridium‐coordinated nanosheets (Ir‐Hemin) with sonodynamic therapy (SDT) properties to effectively induce ferroptosis in tumor cells through multiple regulatory pathways are proposed. Under ultrasound (US) irradiation, Ir‐Hemin nanosheets act as nanosonosensitizers to effectively generate ROS, subsequently causing the accumulation of lipid peroxides (LPO) and inducing ferroptotic cell death. Furthermore, these Ir‐Hemin nanosheets decompose quickly to release hemin and Ir(IV), which deplete intracellular glutathione (GSH) to deactivate the enzyme glutathione peroxidase 4 (GPX4) and initiate the ferroptosis pathway. Specifically, the released hemin enables heme oxygenase 1 (HO‐1) upregulation for endogenous ferrous ion supplementation, which compensates for the toxicity concerns brought about by the large uptake of exogenous iron. Surprisingly, Ir‐Hemin nanosheets exhibit high tumor accumulation and trigger effective ferroptosis for tumor therapy. These Ir‐Hemin nanosheets display pronounced synergistic anticancer efficacy under US stimulation both in vitro and in vivo, providing a strong rationale for the application of ferroptosis in cancer treatment.
An acidity‐biodegradable Ir‐Hemin nanosheet reported in this work presents a typical paradigm to achieve notable ferroptosis efficacy through multiple regulatory pathways, including SDT‐triggered ROS generation, GSH depletion‐induced GPX4 inhibition and HO‐1 upregulation‐mediated endogenous Fe2+ elevation. The findings pave a new way for future studies exploring nanomaterials as ferroptosis inducers.
The gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia ...intestinalis, and the neurotransmitter homovanillic acid (HVA) in individuals with depression and mouse depression models. Although R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. This highlights a synergistic interaction among gut microbiota in regulating intestinal neurotransmitter production. Administering HVA, B. longum, or R. intestinalis to mouse models with chronic unpredictable mild stress (CUMS) and corticosterone (CORT)-induced depression significantly improved depressive symptoms. Mechanistically, HVA inhibited synaptic autophagic death by preventing excessive degradation of microtubule-associated protein 1 light chain 3 (LC3) and SQSTM1/p62 proteins, protecting hippocampal neurons’ presynaptic membrane. These findings underscore the role of the gut microbial metabolism in modulating synaptic integrity and provide insights into potential novel treatment strategies for depression.
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•HVA levels are depleted along with altered gut bacteria in people with depression•R. intestinalis promotes the abundance of B. longum for HVA production•Treatment with HVA, B. longum, or R. intestinalis alleviates depression in mice•HVA restores synaptic function by inhibiting autophagic death
The study by Zhao et al. shows that administering intestinal B. longum, R. intestinalis, or the neurotransmitter, homovanillic acid, improved depressive symptoms in mice. This highlights the role of gut microbial metabolism in maintaining synaptic integrity and suggests potential treatment strategies for depression.
Ferroptosis
In article 2202562 by Longchen Wang, Jianrong Wu, Tao Ying, and co‐workers, an aciditybiodegradable Ir‐Hemin nanosheet is presented to achieve notable ferroptosis efficacy through ...multiple regulatory pathways, including SDT‐triggered ROS generation, GPX4 inhibition and HO‐1 upregulation‐mediated endogenous Fe2+ elevation. This work paves a new way for future studies exploring nanomaterials as ferroptosis inducers.
In this paper, an improved fuzzy comprehensive evaluation method based on entropy is proposed to evaluate the quality of the cultivation of undergraduate talents in logistics management major. ...Firstly, this paper studies and analyzes the literature related to the quality of undergraduate training of logistics management major, and puts forward a set of evaluation index system of the quality of undergraduate training of logistics management major. Secondly, entropy method is used to determine the objective weight of each index. On this basis, the improved fuzzy comprehensive evaluation method is used to rank the quality of logistics management and engineering undergraduate talent cultivation.
With the increasing awareness of global environmental protection, people pay more and more attention to the selection of green suppliers. In addition to choosing the right suppliers, the buyers pay ...more attention to the green suppliers. To solve this problem, we use PROMETHEE method and hesitant fuzzy linguistic to study. Hesitation and language are good at converting language terms into clear, simple forms of computation. PROMETHEE defines the net flow of a scheme and gives the full order of all schemes, because different hesitant fuzzy linguistic can not be calculated directly, this paper uses hesitant fuzzy linguistic PROMETHEE method to study the green supplier selection.
Phase change materials (PCMs) based thermal energy storage (TES) has proved to have great potential in various energy-related applications. The high energy storage density enables TES to eliminate ...the imbalance between energy supply and demand. With the fast-rising demand for cold energy, cold thermal energy storage is becoming very appealing. In this paper, a review of TES for cold energy storage consisting of various liquid-solid low-temperature PCMs has been carried out. The classification of the PCMs is briefly introduced. Recent approaches to optimizing the properties of PCMs, particularly to remedy the poor thermal conductivity, leakage of liquid PCMs and the high degree of super-cooling, which limits the cold applications of TES, have also been reviewed. Methods for increasing the thermal performance including using composite PCMs and solid mesh are compared. Both modelling and experimental research on cold energy storage devices have been examined. The current cold energy storage applications including air conditioning, free cooling, etc. have been summarised. Compared with previous reviews, this work emphasises the cold energy storage applications instead of the materials aspects. The main challenges and approaches to cold thermal energy storage from the perspective of the engineering applications have been identified. Recommendations for future low charging rates and device design methodology are proposed.
•Recent approaches to optimizing PCMs properties have been reviewed.•Both modelling and experimental researches on cold energy storage devices have been examined.•Main challenges and approaches on cold thermal energy storage engineering applications have been identified.•Recommendations on low charging rate issue and device design methodology have been proposed.
Chiral nanophotonic devices are promising candidates for chiral molecule sensing, polarization of diverse nanophotonics, and display technologies. Active chiral nanophotonic devices, where the ...optical chirality can be controlled by an external stimulus has triggered great research interest. However, efficient modulation of the optical chirality has been challenging. Here, we demonstrate switching of the extrinsic chirality by applied magnetic fields in a magnetoplasmonic metasurface device based on a magneto-optical oxide material, Ce1Y2Fe5O12 (Ce:YIG). Due to the low optical loss and strong magneto-optical effect of Ce:YIG, we experimentally demonstrated giant and continuous far-field circular dichroism (CD) modulation by applied magnetic fields from −0.6 ± 0.2° to +1.9 ± 0.1° at 950 nm wavelength under glancing incident conditions. The far-field CD modulation is due to both magneto-optical circular dichroism and near-field modulation of the superchiral fields by applied magnetic fields. Finally, we demonstrate magnetic-field-tunable chiral imaging in millimeter-scale magnetoplasmonic metasurfaces fabricated using self-assembly.
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