We report on the first observation of a radio-quiet Active Galactic Nucleus (AGN) inpolarized X-rays: the Seyfert 1.9 galaxy MCG-05-23-16. This source was pointed at with theImaging X-ray Polarimetry ...Explorer(IXPE) starting on May 14, 2022 for a net observing timeof 486 ks, simultaneously with XMM-Newton(58 ks) andNuSTAR(83 ks). A polarizationdegreeΠsmaller than 4.7% (at the 99% confidence level) is derived in the 2–8 keV energyrange, where emission is dominated by the primary component ascribed to the hot corona.The broad-band spectrum, inferred from a simultaneous fit to theIXPE,NuSTAR, and XMM-Newtondata, is well reproduced by a power law with photon indexΓ=1.85±0.01and ahigh-energy cutoffEC=120±15keV. A comparison with Monte Carlo simulations showsthat a lamp-post and a conical geometry of the corona are consistent with the observed upperlimit, a slab geometry is allowed only if the inclination angle of the system is less than 50◦
Febrile status epilepticus (FSE) has been associated with hippocampal injury and subsequent mesial temporal sclerosis and temporal lobe epilepsy. However, little is known about the semiology of FSE.
...A prospective, multicenter study of the consequences of FSE included children, aged 1 month through 5 years, presenting with a febrile seizure lasting 30 minutes or more. Procedures included neurologic history and examination and an MRI and EEG within 72 hours. All information related to seizure semiology was reviewed by three epileptologists blinded to MRI and EEG results and to subsequent outcome. Inter-rater reliability was assessed by the kappa statistic.
Among 119 children, the median age was 1.3 years, the mean peak temperature was 103.2 degrees F, and seizures lasted a median of 68.0 minutes. Seizure duration followed a Weibull distribution with a shape parameter of 1.68. Seizures were continuous in 52% and behaviorally intermittent (without recovery in between) in 48%; most were partial (67%) and almost all (99%) were convulsive. In one third of cases, FSE was unrecognized in the emergency department. Of the 119 children, 86% had normal development, 24% had prior febrile seizures, and family history of febrile seizures in a first-degree relative was present in 25%.
Febrile status epilepticus is usually focal and often not well recognized. It occurs in very young children and is usually the first febrile seizure. Seizures are typically very prolonged and the distribution of seizure durations suggests that the longer a seizure continues, the less likely it is to spontaneously stop.
Due to be launched in late 2021, the Imaging X-ray Polarimetry Explorer (IXPE) is a NASA Small Explorer mission designed to perform polarization measurements in the 2–8 keV band, complemented with ...imaging, spectroscopy and timing capabilities. At the heart of the focal plane is a set of three polarization-sensitive Gas Pixel Detectors (GPD), each based on a custom ASIC acting as a charge-collecting anode.
In this paper we shall review the design, manufacturing, and test of the IXPE focal-plane detectors, with particular emphasis on the connection between the science drivers, the performance metrics and the operational aspects. We shall present a thorough characterization of the GPDs in terms of effective noise, trigger efficiency, dead time, uniformity of response, and spectral and polarimetric performance. In addition, we shall discuss in detail a number of instrumental effects that are relevant for high-level science analysis—particularly as far as the response to unpolarized radiation and the stability in time are concerned.
ABSTRACT
We report spectro-polarimetric results of an observational campaign of the bright neutron star low-mass X-ray binary Cyg X-2 simultaneously observed by IXPE, NICER, and INTEGRAL. ...Consistently with previous results, the broad-band spectrum is characterized by a lower-energy component, attributed to the accretion disc with kTin ≈ 1 keV, plus unsaturated Comptonization in thermal plasma with temperature kTe = 3 keV and optical depth τ ≈ 4, assuming a slab geometry. We measure the polarization degree in the 2–8 keV band P = 1.8 ± 0.3 per cent and polarization angle ϕ = 140° ± 4°, consistent with the previous X-ray polarimetric measurements by OSO-8 as well as with the direction of the radio jet which was earlier observed from the source. While polarization of the disc spectral component is poorly constrained with the IXPE data, the Comptonized emission has a polarization degree P = 4.0 ± 0.7 per cent and a polarization angle aligned with the radio jet. Our results strongly favour a spreading layer at the neutron star surface as the main source of the polarization signal. However, we cannot exclude a significant contribution from reflection off the accretion disc, as indicated by the presence of the iron fluorescence line.
We report on a comprehensive analysis of simultaneous X-ray polarimetric and spectral data of the bright atoll source GX 9+9 with the Imaging X-ray Polarimetry Explorer (IXPE) and
NuSTAR
. The source ...is significantly polarized in the 4–8 keV band, with a degree of 2.2% ± 0.5% (uncertainty at the 68% confidence level). The
NuSTAR
broad-band spectrum clearly shows an iron line, and is well described by a model including thermal disc emission, a Comptonized component, and reflection. From a spectro-polarimetric fit, we obtain an upper limit to the polarization degree of the disc of 4% (at the 99% confidence level), while the contribution of Comptonized and reflected radiation cannot be conclusively separated. However, the polarization is consistent with resulting from a combination of Comptonization in a boundary or spreading layer, plus reflection off the disc, which significantly contributes in any realistic scenario.
ABSTRACT
We report on an X-ray polarimetric observation of the high-mass X-ray binary LMC X-1 in the high/soft state, obtained by the Imaging X-ray Polarimetry Explorer (IXPE) in 2022 October. The ...measured polarization is below the minimum detectable polarization of 1.1 per cent (at the 99 per cent confidence level). Simultaneously, the source was observed with the Neutron Star Interior Composition Explorer (NICER), Nuclear Spectroscopic Telescope Array (NuSTAR), and Spectrum-Rontgen-Gamma (SRG)/Astronomical Roentgen Telescope – X-ray Concentrator (ART-XC) instruments, which enabled spectral decomposition into a dominant thermal component and a Comptonized one. The low 2–8 keV polarization of the source did not allow for strong constraints on the black hole spin and inclination of the accretion disc. However, if the orbital inclination of about 36° is assumed, then the upper limit is consistent with predictions for pure thermal emission from geometrically thin and optically thick discs. Assuming the polarization degree of the Comptonization component to be 0, 4, or 10 per cent, and oriented perpendicular to the polarization of the disc emission (in turn assumed to be perpendicular to the large-scale ionization cone orientation detected in the optical band), an upper limit to the polarization of the disc emission of 1.0, 0.9, or 0.9 per cent, respectively, is found (at the 99 per cent confidence level).
X Persei is a persistent low-luminosity X-ray pulsar of period of ≈ 835 s in a Be binary system. The field strength at the neutron star surface is not known precisely, but indirect signs indicate a ...magnetic field above 1013 G, which makes the object one of the most magnetized known X-ray pulsars. Here we present the results of observations X Persei performed with the Imaging X-ray Polarimetry Explorer (IXPE). The X-ray polarization signal was found to be strongly dependent on the spin phase of the pulsar. The energy-averaged polarization degree in 3–8 keV band varied from several to ∼20 per cent over the pulse with a phase dependence resembling the pulse profile. The polarization angle shows significant variation and makes two complete revolutions during the pulse period, resulting in nearly nil pulse-phase averaged polarization. Applying the rotating vector model to the IXPE data we obtain the estimates for the rotation axis inclination and its position angle on the sky, as well as for the magnetic obliquity. The derived inclination is close to the orbital inclination, reported earlier for X Persei. The polarimetric data imply a large angle between the rotation and magnetic dipole axes, which is similar to the result reported recently for the X-ray pulsar GRO J1008−57. After eliminating the effect of polarization angle rotation over the pulsar phase using the best-fitting rotating vector model, the strong dependence of the polarization degree with energy was discovered, with its value increasing from 0 at ∼2 keV to 30per cent at 8 keV.
Objective
Abnormal function of high‐density lipoprotein (HDL) has been implicated as a potential mechanism for the increased incidence of cardiovascular (CV) disease in patients with rheumatoid ...arthritis (RA). This study was undertaken to evaluate changes in HDL function and HDL‐associated proteins over 2 years of follow‐up in patients with early RA receiving either methotrexate (MTX) monotherapy, MTX + etanercept (ETN) combination therapy, or MTX + sulfasalazine (SSZ) + hydroxychloroquine (HCQ) triple therapy in the Treatment of Early Aggressive Rheumatoid Arthritis (TEAR) trial.
Methods
The antioxidant capacity of HDL, paraoxonase 1 (PON‐1) activity, and levels of HDL‐associated haptoglobin (Hp), HDL‐associated apolipoprotein A‐I (Apo A‐I), and myeloperoxidase (MPO) were measured in 550 TEAR participants at 4 time points (time 0 pretreatment and at 24, 48, and 102 weeks of treatment). Repeated‐measures analysis using mixed‐effects linear models with an autoregressive covariate structure was performed to model the within‐subject covariance over time.
Results
Mixed‐effects models, which were controlled for traditional CV risk factors, treatment regimen, prednisone use, and statin use, demonstrated significant associations between RA disease activity, measured using the Disease Activity Score in 28 joints, erythrocyte sedimentation rate, or C‐reactive protein level, and the profile of HDL function over time. Specifically, decreases in RA disease activity over time were associated with increases in PON‐1 activity and levels of HDL‐associated Apo A‐I, and decreases in the HDL inflammatory index and levels of MPO and HDL‐associated Hp.
Conclusion
Reduced disease activity in patients with early RA treated with MTX monotherapy, MTX + ETN combination therapy, or MTX + SSZ + HCQ triple therapy in the TEAR trial was associated with improvements in the HDL function profile. Additional studies are warranted to evaluate abnormal HDL function as a potential mechanism and therapeutic target for CV risk in patients with RA.
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