This study assessed the effects of COVID-19 home confinement on physical activity, sedentary behavior, smartphone use, and sleep patterns. Data was collected in a sample of 20 young adults (mean age ...± SD: 22.6 ± 3.4 years; 55% males) over seven days pre- and during the COVID-19 lockdown. Objective and subjective physical activity (Accelerometer and the International Physical Activity Questionnaire (IPAQ), respectively), the number of hours sitting (IPAQ), objectively-measured smartphone use (smartphone screen time applications), and objective and subjective sleep (accelerometer and the Pittsburgh Sleep Quality Index, respectively) were assessed. Results revealed significantly greater walking time and mean steps (p < 0.001, d = 1.223 to 1.605), and moderate and vigorous physical activity (p < 0.05, d = 0.568 to 0.616), in the pre- compared with the during-COVID-19 lockdown phase. Additionally, smartphone use (p = 0.009, d = 0.654), sitting time (p = 0.002, d = 1.120), and total sleep (p < 0.004, d = 0.666) were significantly greater in the during- compared with the pre-COVID-19 lockdown phase. Multiple regressions analyses showed associations between physical activity and sedentary behavior and sleep quality. The number of hours sitting per day and moderate-to-vigorous physical activity significantly predicted deep sleep (adj.R2 = 0.46). In conclusion, this study revealed that during the COVID-19 outbreak, behaviors changed, with participants spending less time engaging in physical activity, sitting more, spending more time using the smartphone, and sleeping more hours. These findings may be of importance to make recommendations, including lifestyle modifications during this time.
Caffeine used as a supplement has been shown to improve physical and cognitive performance in several sport modalities due to its effects on the central nervous system. This review assesses the ...direct effects of caffeine supplementation on performance in combat sports. Using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines, relevant studies were identified through the Medline, Scopus and SPORTDiscus databases. Of 1053 search results, only 9 articles fulfilled the inclusion criteria. Of these, three studies detected no ergogenic effect of caffeine supplementation, while six studies did observe a significant positive effect. Supplementation with 3-6 mg/kg of caffeine was found to increase the glycolytic contribution to energy metabolism during the execution of real or simulated combats, as indicated by elevated blood lactate concentrations. Caffeine intake was also noted to improve levels of strength, power and upper arm muscular endurance. These effects were not paralleled by an increase in the exertion perceived by the athlete.
Abstract The increasing prevalence of chronic and hospital-acquired infections produced by multidrug-resistant (MDR) or extensively drug-resistant (XDR) Pseudomonas aeruginosa strains is associated ...with significant morbidity and mortality. This growing threat results from the extraordinary capacity of this pathogen for developing resistance through chromosomal mutations and from the increasing prevalence of transferable resistance determinants, particularly those encoding carbapenemases or extended-spectrum β-lactamases (ESBLs). P. aeruginosa has a nonclonal epidemic population structure, composed of a limited number of widespread clones which are selected from a background of a large quantity of rare and unrelated genotypes that are recombining at high frequency. Indeed, recent concerning reports have provided evidence of the existence of MDR/XDR global clones, denominated high-risk clones, disseminated in hospitals worldwide; ST235, ST111, and ST175 are likely those more widespread. Noteworthy, the vast majority of infections by MDR, and specially XDR, strains are produced by these and few other clones worldwide. Moreover, the association of high-risk clones, particularly ST235, with transferable resistance is overwhelming; nearly 100 different horizontally-acquired resistance elements and up to 39 different acquired β-lactamases have been reported so far among ST235 isolates. Likewise, MDR internationally-disseminated epidemic strains, such as the Liverpool Epidemic Strain (LES, ST146), have been noted as well among cystic fibrosis patients. Here we review the population structure, epidemiology, antimicrobial resistance mechanisms and virulence of the P. aeruginosa high-risk clones. The phenotypic and genetic factors potentially driving the success of high-risk clones, the aspects related to their detection in the clinical microbiology laboratory and the implications for infection control and public health are also discussed.
Childhood and adolescent obesity has become one of the most vital challenges to overcome in the present age. Physical fitness, physical activity and the Mediterranean diet (MD) are valuable tools for ...its prevention and treatment. The main objective of this study is to analyze the associations between health-related physical fitness components, body composition and adherence to the MD in 917 adolescents aged from 13- to 16-years-old. The ALPHA-Fitness Test was used to measure physical fitness and body composition, and the Adherence to the Mediterranean Diet (KIDMED) questionnaire was employed to assess the adherence to the MD. The associations between variables were tested according to gender and age a generalized linear model (GLM) univariate analysis (two factors) and one-way analysis of variance (ANOVA, with Bonferroni posthoc). As to the body composition and physical fitness variables, significant differences were obtained in both genders but not in relation to the adherence to the MD. The boys performed better in the physical fitness tests. Age was a determinant factor in adherence to the MD in the total sample, lowering as the age of the sample increases. Both the boys and girls who had a significantly higher performance in the endurance test were those who showed high/medium adherence to the MD. It is concluded that higher levels of cardiovascular endurance in boys and girls are associated with a medium and high adherence to the MD.
•A new optimization algorithm based on Lichtenberg figure pattern is presented.•Difussion Limited Aggregation is formulated to create new agents in search space.•Lichtenberg figure pattern presents ...exploration–exploitation balance.•Tested on complex functions and problems and compared with renowned metaheuristics.
This paper proposes a novel global optimization algorithm called Lichtenberg Algorithm (LA), inspired by the Lichtenberg figures patterns. Optimization is an essential tool to minimize or maximize functions, obtaining optimal results on costs, mass, energy, gains, among others. Actual problems may be multimodal, nonlinear, and discontinuous and may not be minimized by classical analytical methods that depend on the gradient. In this context there are metaheuristics algorithms inspired by natural phenomena to optimize real problems. There is no algorithm that is the worst or the best, but more efficient for a given type of problem. Thus, an unprecedented metaheuristic algorithm was created inspired by the physical phenomenon of radial intra-cloud lightning and Lichtenberg figures, successfully exploiting the fractal power and it is different from many in the literature as it is a hybrid algorithm composed of methods of search based on population and trajectory. Several test functions, including a design problem in a welded beam, were used to verify the robustness and to validate the Lichtenberg Algorithm. In all cases, the results were satisfactory when compared to those in the literature. LA shown to be a powerful optimization tool for both unconstraint optimizations and real problems with linear and nonlinear constraints.
In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant or extensively drug-resistant (MDR/XDR)
has become a public health threat. This article reviews their ...mechanisms of resistance, epidemiology, and clinical impact and current and upcoming therapeutic options.
and
treatment studies and pharmacokinetic and pharmacodynamic (PK/PD) models are discussed. Polymyxins are reviewed as an important therapeutic option, outlining dosage, pharmacokinetics and pharmacodynamics, and their clinical efficacy against MDR/XDR
infections. Their narrow therapeutic window and potential for combination therapy are also discussed. Other "old" antimicrobials, such as certain β-lactams, aminoglycosides, and fosfomycin, are reviewed here. New antipseudomonals, as well as those in the pipeline, are also reviewed. Ceftolozane-tazobactam has clinical activity against a significant percentage of MDR/XDR
strains, and its microbiological and clinical data, as well as recommendations for improving its use against these bacteria, are described, as are those for ceftazidime-avibactam, which has better activity against MDR/XDR
, especially strains with certain specific mechanisms of resistance. A section is devoted to reviewing upcoming active drugs such as imipenem-relebactam, cefepime-zidebactam, cefiderocol, and murepavadin. Finally, other therapeutic strategies, such as use of vaccines, antibodies, bacteriocins, anti-quorum sensing, and bacteriophages, are described as future options.
The concepts of active disturbance rejection control and flatness-based control are used in this paper to regulate the response of a dc-to-dc buck power converter affected by unknown, exogenous, ...time-varying load current demands. The generalized proportional integral observer is used to estimate and cancel the time-varying disturbance signals. A key element in the proposed control for the buck converter-dc motor combination is that even if the control input gain is imprecisely known, the control strategy still provides proper regulation and tracking. The robustness of this method is further extended to the case of a double buck topology driving two different dc motors affected by different load torque disturbances. Simulation results are provided.
Iron deficiency is a frequent and multifactorial disorder in the career of athletes, particularly in females. Exercise-induced disturbances in iron homeostasis produce deleterious effects on ...performance and adaptation to training; thus, the identification of strategies that restore or maintain iron homeostasis in athletes is required. Hepcidin is a liver-derived hormone that degrades the ferroportin transport channel, thus reducing the ability of macrophages to recycle damaged iron, and decreasing iron availability. Although it has been suggested that the circulating fraction of hepcidin increases during early post-exercise recovery (~3 h), it remains unknown how an acute exercise bout may modify the circulating expression of hepcidin. Therefore, the current review aims to determine the post-exercise expression of serum hepcidin in response to a single session of exercise. The review was carried out in the Dialnet, Elsevier, Medline, Pubmed, Scielo and SPORTDiscus databases, using hepcidin (and "exercise" or "sport" or "physical activity") as a strategy of search. A total of 19 articles were included in the review after the application of the inclusion/exclusion criteria. This search found that a single session of endurance exercise (intervallic or continuous) at moderate or vigorous intensity (60-90% VO
) stimulates an increase in the circulating levels of hepcidin between 0 h and 6 h after the end of the exercise bout, peaking at ~3 h post-exercise. The magnitude of the response of hepcidin to exercise seems to be dependent on the pre-exercise status of iron (ferritin) and inflammation (IL-6). Moreover, oxygen disturbances and the activation of a hypoxia-induced factor during or after exercise may stimulate a reduction of hepcidin expression. Meanwhile, cranberry flavonoids supplementation promotes an anti-oxidant effect that may facilitate the post-exercise expression of hepcidin. Further studies are required to explore the effect of resistance exercise on hepcidin expression.
The growing use of external management consultancy services by public sector organizations has generated controversy. Some claim that users have become overreliant on, or even addicted to, this ...source of knowledge. However, our understanding of this phenomenon and the precise nature of its risks is underdeveloped. In this article, we address these concerns by focusing on whether using consulting services inflates future demand and on its consequences for efficiency. This is examined in the context of the English National Health Service and the adoption of New Public Management practices such as outsourcing and private finance initiative contracting. Based on an analysis of four years of data, the results suggest that using consulting services is associated with demand inflation and has negative implications for client organizational efficiency. These findings reveal a strong management consultancy effect, emphasizing the risks associated with demand inflation, with implications for both theory and policy.
Sports supplements (SS) are commonly used by athletes to improve their performance. SS use by competitive swimmers is reported to be prevalent but there is no evidence of such use by elite swimmers, ...either male or female. The objective of this research was to study the patterns of SS use by competitive swimmers based on sex and competitive levels (national and international); Methods: Using the categories of the Australian Institute of Sport (AIS), a total of 102 competitive swimmers (59 men and 43 women) completed a validated self-administered questionnaire on the use of SS; (3) Results: Overall, 86.9% of swimmers had consumed SSs with no differences observed between males and females (p = 0.247) or between competitive levels (p = 0.597). The SS that were most consumed by swimmers were caffeine (53.5%), sport drinks (52.5%), sport bars (51.5%), and vitamin C (43.4%). SSs categorized as medical supplements were consumed significantly more frequently by international swimmers (p = 0.012), with significant differences also found in the level—sex interaction (p = 0.049); (4) Conclusions: Compared to other sports disciplines, the prevalence of SS consumption is high in competitive swimmers regardless of performance level or gender. However, the consumption of medical supplements was greater in swimmers at a higher performance level.
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