Context.
Massive stars end their lives in catastrophic supernova (SN) explosions. Key information on the explosion processes and on the progenitor stars can be extracted from observations of ...supernova remnants (SNRs), which are the outcome of SNe. Deciphering these observations, however, is challenging because of the complex morphology of SNRs.
Aims.
We aim to link the dynamical and radiative properties of the remnant of SN 1987A to the geometrical and physical characteristics of the parent aspherical SN explosion and to the internal structure of its progenitor star.
Methods.
We performed comprehensive three-dimensional hydrodynamic simulations which describe the long-term evolution of SN 1987A from the onset of the SN to the full-fledged remnant at the age of 50 years, accounting for the pre-SN structure of the progenitor star. The simulations include all physical processes relevant for the complex phases of SN evolution and for the interaction of the SNR with the highly inhomogeneous ambient environment around SN 1987A. Furthermore, the simulations follow the life cycle of elements from the synthesis in the progenitor star through the nuclear reaction network of the SN to the enrichment of the circumstellar medium as a result of the mixing of chemically homogeneous layers of ejecta. From the simulations, we synthesize observables that are to be compared with observations.
Results.
By comparing the model results with observations, we constrained the initial SN anisotropy causing Doppler shifts, observed in the emission lines of heavy elements from ejecta, and leading to the remnant evolution observed in the X-ray band in the last thirty years. In particular, we found that the high mixing of ejecta unveiled by high redshifts and broadenings of Fe II and
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Ti lines require a highly asymmetric SN explosion channeling a significant fraction of energy along an axis that is almost lying in the plane of the central equatorial ring around SN 1987A, roughly along the line-of-sight, but with an offset of 40°, with the lobe propagating away from the observer slightly more energetic than the other. Furthermore, we found unambiguously that the observed distribution of ejecta and the dynamical and radiative properties of the SNR can be best reproduced if the structure of the progenitor star was that of a blue supergiant which had resulted from the merging of two massive stars.
Autonomous vehicles need to plan trajectories to a specified goal that avoid obstacles. For robust execution, we must take into account uncertainty, which arises due to uncertain localization, ...modeling errors, and disturbances. Prior work handled the case of set-bounded uncertainty. We present here a chance-constrained approach, which uses instead a probabilistic representation of uncertainty. The new approach plans the future probabilistic distribution of the vehicle state so that the probability of failure is below a specified threshold. Failure occurs when the vehicle collides with an obstacle or leaves an operator-specified region. The key idea behind the approach is to use bounds on the probability of collision to show that, for linear-Gaussian systems, we can approximate the nonconvex chance-constrained optimization problem as a disjunctive convex program. This can be solved to global optimality using branch-and-bound techniques. In order to improve computation time, we introduce a customized solution method that returns almost-optimal solutions along with a hard bound on the level of suboptimality. We present an empirical validation with an aircraft obstacle avoidance example.
Summary
Studies on regulatory T cells (Treg) have focused on thymic Treg as a stable lineage of immunosuppressive T cells, the differentiation of which is controlled by the transcription factor ...forkhead box protein 3 (Foxp3). This lineage perspective, however, may constrain hypotheses regarding the role of Foxp3 and Treg in vivo, particularly in clinical settings and immunotherapy development. In this review, we synthesize a new perspective on the role of Foxp3 as a dynamically expressed gene, and thereby revisit the molecular mechanisms for the transcriptional regulation of Foxp3. In particular, we introduce a recent advancement in the study of Foxp3‐mediated T cell regulation through the development of the Timer of cell kinetics and activity (Tocky) system, and show that the investigation of Foxp3 transcriptional dynamics can reveal temporal changes in the differentiation and function of Treg in vivo. We highlight the role of Foxp3 as a gene downstream of T cell receptor (TCR) signalling and show that temporally persistent TCR signals initiate Foxp3 transcription in self‐reactive thymocytes. In addition, we feature the autoregulatory transcriptional circuit for the Foxp3 gene as a mechanism for consolidating Treg differentiation and activating their suppressive functions. Furthermore, we explore the potential mechanisms behind the dynamic regulation of epigenetic modifications and chromatin architecture for Foxp3 transcription. Lastly, we discuss the clinical relevance of temporal changes in the differentiation and activation of Treg.
The recent technological advancements show that Foxp3 transcription is dynamically regulated in vivo. In this review, we synthesize a new perspective on the role of Foxp3 as a dynamically expressed gene, and thereby revisit the molecular mechanisms for the transcriptional regulation of Foxp3 and discuss the implications for basic and clinical studies.
ABSTRACT
The detected polarized radio emission from the remnant of SN1987A opens the possibility to unveil the structure of the pre-supernova (pre-SN) magnetic field (MF) in the circumstellar medium. ...Properties derived from direct measurements would be of importance for understanding the progenitor stars and their MFs. As the first step to this goal, we adopted the hydrodynamic (HD) data from an elaborated three-dimensional (3D) numerical model of SN1987A. We have developed an approximate method for ‘reconstruction’ of 3D MF structure inside SN remnant on the 'HD background’. This method uses the distribution of the MF around the progenitor as the initial condition. With such a 3D magnetohydrodynamic model, we have synthesized the polarization maps for a number of SN1987A models and compared them to the observations. In this way, we have tested different initial configurations of the MF as well as a structure of the synchrotron emission in SN987A. We have recovered the observed polarization pattern and we have found that the radial component of the ambient pre-SN MF should be dominant on the length-scale of the present-day radius of SN1987A. The physical reasons for such a field are discussed.
Impaired cerebral autoregulation may predispose patients to cerebral hypoperfusion during cardiopulmonary bypass (CPB). The purpose of this study was to identify risk factors for impaired ...autoregulation during coronary artery bypass graft, valve surgery with CPB, or both and to evaluate whether near-infrared spectroscopy (NIRS) autoregulation monitoring could be used to identify this condition.
Two hundred and thirty-four patients were monitored with transcranial Doppler and NIRS. A continuous, moving Pearson’s correlation coefficient was calculated between mean arterial pressure (MAP) and cerebral blood flow (CBF) velocity, and between MAP and NIRS data, to generate the mean velocity index (Mx) and cerebral oximetry index (COx), respectively. Functional autoregulation is indicated by an Mx and COx that approach zero (no correlation between CBF and MAP); impaired autoregulation is indicated by an Mx and COx approaching 1. Impaired autoregulation was defined as an Mx ≥0.40 at all MAPs during CPB.
Twenty per cent of patients demonstrated impaired autoregulation during CPB. Based on multivariate logistic regression analysis, time-averaged COx during CPB, male gender, PaCO2, CBF velocity, and preoperative aspirin use were independently associated with impaired CBF autoregulation. Perioperative stroke occurred in six of 47 (12.8%) patients with impaired autoregulation compared with five of 187 (2.7%) patients with preserved autoregulation (P=0.011).
Impaired CBF autoregulation occurs in 20% of patients during CPB. Patients with impaired autoregulation are more likely than those with functional autoregulation to have perioperative stroke. Non-invasive monitoring autoregulation may provide an accurate means to predict impaired autoregulation.
Clinical trials registration. www.clinicaltrials.gov (NCT00769691).
When the local heat flux exceeds specified flux limit, tungsten PFC surfaces can be damaged, which is not acceptable for a reliable reactor operations. The divertor PFCs are typically designed for a ...specific heat flux limit usually assuming an average steady-state heat flux which is typically 5–10 MW/m
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. However, in addition to steady-state heat flux, fusion reactor divertor PFCs could experience transient heat fluxes such as ELMs and/or other magnetic reconnection events which can deposit large transient heat fluxes onto the divertor PFCs. The transient divertor heat flux could be significantly larger than the steady-state heat flux which could damage the solid PFC surfaces. The divertor heat flux can be subjected to additional complications such as the uncertainties in the the divertor strike point heat flux projection. Moreover, there are additional experimental observations of non-axisymmetric power flux which can occur under non-axisymmetric magnetic perturbations. The liquid lithium (LL) PFCs is more resilient against such transient heat fluxes as they could evaporate LL as needed and the lost LL can be then replenished afterward. In this paper, we analyze a case for a transient divertor heat pulse of 1 MJ in 10 ms for a ITER-size reactor. This is a small perturbation (~ 0.1%) to the expected plasma stored energy compared to the previously analyzed case of 20 MJ heat pulse. Even with this relatively modest heat pulse, the LL surface undergoes ~ 100 °C temperature rise. However, the resulting LL surface heating without rapid cooldown mechanism could lead to excessive LL evaporation continuing well after the transient heat flux resulting in a significant Li injection of ~ 0.6 mol in about a 200 ms period. This amount of Li injection could cause plasma dilution and performance degradation. On the other hand, an active Li injection capability if optimized could prevent the LL surface temperature rise and thus reducing subsequent Li evaporation into the plasma by a factor of 7 compared to the passive LL PFC case. A crucial tool of active Li injection is a rapid response pellet injector which could inject light impurity pellets before the excessive heat flux could reach the divertor plate causing serious damage. A simple pellet ablation model suggests a favorable pellet deposition profile for smaller ~ 0.1 mm radius pellet with ~ 10–20 m/s velocity. Moreover, if it is possible to inject from the private flux region, the pellet injection efficiency into the high heat flux strike point region can be as high as 80% compared to ~ 50% for the injection from outer radius region. The pellet deposition efficiency can be further improved by designing a shell-pellet which can burst when a certain ablation fraction is reached. A possible implementation technique using an inductive pellet injector with a rapid time response of a few msec is proposed here which can be tested in NSTX-U.
The Telescope Array (TA) observatory utilizes fluorescence detectors and surface detectors (SDs) to observe air showers produced by ultra high energy cosmic rays in Earth's atmosphere. Cosmic-ray ...events observed in this way are termed hybrid data. The depth of air shower maximum is related to the mass of the primary particle that generates the shower. This paper reports on shower maxima data collected over 8.5 yr using the Black Rock Mesa and Long Ridge fluorescence detectors in conjunction with the array of SDs. We compare the means and standard deviations of the observed X max distributions with Monte Carlo X max distributions of unmixed protons, helium, nitrogen, and iron, all generated using the QGSJet II-04 hadronic model. We also perform an unbinned maximum likelihood test of the observed data, which is subjected to variable systematic shifting of the data X max distributions to allow us to test the full distributions, and compare them to the Monte Carlo to see which elements are not compatible with the observed data. For all energy bins, QGSJet II-04 protons are found to be compatible with TA hybrid data at the 95% confidence level after some systematic X max shifting of the data. Three other QGSJet II-04 elements are found to be compatible using the same test procedure in an energy range limited to the highest energies where data statistics are sparse.
This study examined the seasonal transition of precipitation characteristics and its association with land surface conditions in and around Bangladesh, where land surface conditions are predominantly ...wet. Hourly rain rate data from the Global Satellite Mapping of Precipitation Microwave‐Infrared Combined Product and 10 day soil moisture data from the Advanced Microwave Scanning Radiometer Earth Observing System were used over the 7 years from 2003 to 2009. Area mean values of soil moisture, and precipitation amount, frequency, and intensity were calculated for each 10 day period. Results showed that higher precipitation amount and frequency were observed over the wet soil conditions, which indicates that soil moisture was influenced by previous precipitation events. However, the soil moisture could also control the precipitation characteristics. The seasonal and interannual variations in all regions suggested that precipitation amount and frequency increased in moist soil conditions, which is associated with an increase of water vapor supplied from the moist land surface. Over a flat plain (87°E–91°E, 23°N–25°N), a higher afternoon precipitation intensity was observed over drier land surfaces. This relationship was observed on seasonal and interannual variations. This suggests that the land surface conditions in this region can affect the afternoon precipitation intensity to some extent, although changes of atmospheric conditions can be a major factor particularly for the seasonal changes. However, this relationship was not observed in mountainous regions. This can be explained by other factors, such as thermally induced local circulations by the surrounding topography, being stronger than the impact of land surface conditions.
Key Points
Drier surface possibly induces the heavier precipitation over the wet Asian monsoon region
Seasonal transition of precipitation characteristics and soil wetness are examined by satellite observations
Role of land surface on precipitation characteristics was discussed over a wet tropical region
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