After travelling to Spain at the end of 1936 with the intention of working as a correspondent for a British socialist newspaper, thirty-three-year-old George Orwell decided to join the Republican ...efforts to overturn Franco's Nationalists in the Spanish Civil War. Having enrolled in the POUM militias, the young writer was soon forced to experience first-hand the hardships and dangers of trench warfare, before becoming involved in the Barcelona May Day street fighting and nearly being killed by a bullet on his return to the front line. Orwell's initial idealistic dreams of a victorious fight against fascism were gradually tainted by doubt and disillusionment as the divisions and infighting within the Republican coalition became apparent.Part war memoir, part tract, part exposé, Homage to Catalonia is a pivotal work in Orwell's oeuvre, and a key to understanding his political ideas and commitment to the socialist cause. Rejected by Orwell's long-standing publisher, Gollancz, on political grounds, it is here presented in its original version, as published by Secker & Warburg in 1938.
There have been many studies of George Orwell, but nothing quite like this book by Alex Woloch—an exuberant, revisionary account of Orwell’s radical writing. Bearing down on the propulsive irony and ...formal restlessness intertwined with his plain-style, Woloch offers a new understanding of Orwell and a new way of thinking about writing and politics.
Neisseria meningitidis is a major cause of bacterial septicemia and meningitis. Sequence variation of surface-exposed proteins and cross-reactivity of the serogroup B capsular polysaccharide with ...human tissues have hampered efforts to develop a successful vaccine. To overcome these obstacles, the entire genome sequence of a virulent serogroup B strain (MC58) was used to identify vaccine candidates. A total of 350 candidate antigens were expressed in Escherichia coli, purified, and used to immunize mice. The sera allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans.
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