Background:
Pregnancy mobile applications (apps) have grown in popularity over the past decade, with some being used to promote study recruitment or health behaviors. However, no app serves as an ...all-in-one solution for collecting general data for research purposes and providing women with useful and desirable features.
Aim:
To create and develop a Swiss pregnancy mobile app as an innovative means to collect research data and provide users with reliable information.
Methods:
Determining the key features of the app involved a review of the literature and assessment of popular apps in the Swiss AppStore. A team of engineers developed the app, which includes a pregnancy timeline, questionnaires for data collection, medical and psychological articles and a checklist with appointment reminders. The content was written and reviewed by healthcare providers considered experts in the topics adressed. The questionnaires are distributed based on the user’s gestational age, by a chatbot. The project was authorized by the ethics commission in the canton of Vaud. An online survey of ten questions, advertised on Datamama’s home screen, was conducted to assess the users’ use of the app (27.11- 19.12.2022).
Results:
A review of 84 articles and 25 popular apps showed the need for a comprehensive pregnancy app. The development of Datamama took 2 years and included the creation of 70 medical and psychological articles and 29 questionnaires covering 300 unique variables. Six months after the launch, there were 800 users with a 73% average participation rate in the questionnaires. Sixty-five women completed the survey, with 70.8% using the app once to multiple times per week. The primary reason for using the app was to help research by answering the questionnaires, followed by access to reliable medical information. The reason most frequently ranked first for using the app was to help research by answering the questionnaires (42/65, 67% of women rated it first), followed by access to reliable medical information (34/65, 54% women rated it second). Women rated the information as clear, understandable, and interesting with a trust rating in data handling at 98.5%. The average grade for recommending the app was 8/10, with suggestions for increasing the amount of medical content and tailoring it based on gestational age.
Conclusion:
Datamama is the first pregnancy app to address the needs of both patients and researchers. Initial feedback from users was positive, highlighting future challenges for success. Future work will consist in improving the app, validating the data and use it to answer specific pregnancy-related research questions.
Dual antiplatelet therapy is commonly used in patients undergoing transcatheter aortic valve implantation (TAVI), but the optimal antiplatelet regimen is uncertain and remains to be determined. The ...objective of this study was to compare 2 strategies of antiplatelet therapy in patients undergoing TAVI. A strategy using monoantiplatelet therapy (group A, n = 164) was prospectively compared with a strategy using dual antiplatelet therapy (group B, n = 128) in 292 consecutive patients undergoing TAVI. The primary end point was a combination of mortality, major stroke, life-threatening bleeding (LTB), myocardial infarction, and major vascular complications at 30 days. All adverse events were adjudicated according to the Valve Academic Research Consortium. The primary end point occurred in 22 patients (13.4%) in the group A and in 30 patients (23.4%) in the group B (hazard ratio 0.51, 95% confidence interval 0.28 to 0.94, p = 0.026). LTB (3.7% vs 12.5%, p = 0.005) and major bleedings (2.4% vs 13.3%, p <0.0001) occurred less frequently in the group A, whereas the incidence of stroke (1.2% vs 4.7%, p = 0.14) and myocardial infarction (1.2% vs 0.8%, p = 1.0) was not significantly different between the 2 groups. The benefit of a strategy using mono versus dual antiplatelet therapy persisted after multivariate adjustment and propensity score analysis (hazard ratio 0.53, 95% confidence interval 0.28 to 0.95, p = 0.033). In conclusion, a strategy using mono versus dual antiplatelet therapy in patients undergoing TAVI reduces LTB and major bleedings without increasing the risk of stroke and myocardial infarction. The results of our study question the justification of dual antiplatelet therapy and require confirmation in a randomized trial.
Highlights • SEBT and LOS scores were inversely related. • Both may be valid but measure different points on the balance continuum. • Care is needed when choosing balance tests.
New models of collective agriculture have been developing in France over the past 10 years that could encourage the emergence of more diversified and sustainable systems. However, as such production ...systems are relatively more complex to manage, the involvement of more people may be required. This raises renewed questions concerning the collective organization of work. Our study’s main hypothesis is that the collective organization of work could encourage crop-livestock integration and underlying agroecological processes. To test this hypothesis, we implemented a participatory design approach in a case study in Camargue (France). We first used ecological network analysis to characterize flows of material between production units and assess associated biotechnical performances, namely, efficiency, resilience, productivity, and dependence. In a second step, we drew from the QuaeWork method, which we adapted to the study of collective farms, to characterize the organizational dimension. These two methods allowed us to generate quantitative indicators related to the performance of the system (expressed in kgN.ha
−1
.yr
−1
) and to calculate and estimate the time spent on various types of work (h.yr
−1
). Using a participatory design approach, we then developed and assessed three scenarios with varying levels of integration between activities. The results indicate that the gradual substitution of external resources by internal resources leads to a broader range of flows within the system, generating performances that vary depending on the scenario. The design of the scenarios revealed the repercussions of the organization of work within production units. The two most integrated scenarios are more efficient and resilient than the scenario without integration between units, but they are less productive. Our research contributes novel insights into the impact of agroecological practices on the organization of work on collective farms. Our findings enable a deeper understanding of the complex link between the collective organization of production and the articulation of activities.
Conditional mutations are essential for determining the stage- and tissue-specific functions of genes. Here we achieve conditional mutagenesis in zebrafish using FT1, a gene-trap cassette that can be ...stably inverted by both Cre and Flp recombinases. We demonstrate that intronic insertions in the gene-trapping orientation severely disrupt the expression of the host gene, whereas intronic insertions in the neutral orientation do not significantly affect host gene expression. Cre- and Flp-mediated recombination switches the orientation of the gene-trap cassette, permitting conditional rescue in one orientation and conditional knockout in the other. To illustrate the utility of this system we analyzed the functional consequence of intronic FT1 insertion in supv3l1 , a gene encoding a mitochondrial RNA helicase. Global supv311 mutants have impaired mitochondrial function, embryonic lethality, and agenesis of the liver. Conditional rescue of supv311 expression in hepatocytes specifically corrected the liver defects. To test whether the liver function of supv311 is required for viability we used Flp-mediated recombination in the germline to generate a neutral allele at the locus. Subsequently, tissue-specific expression of Cre conditionally inactivated the targeted locus. Hepatocyte-specific inactivation of supv311 caused liver degeneration, growth retardation, and juvenile lethality, a phenotype that was less severe than the global disruption of supv311 . Thus, supv311 is required in multiple tissues for organismal viability. Our mutagenesis approach is very efficient and could be used to generate conditional alleles throughout the zebrafish genome. Furthermore, because FT1 is based on the promiscuous Tol2 transposon, it should be applicable to many organisms.
To expand our knowledge of the climate in the Lesser Antilles, we attempted to identify the spatio-temporal configurations of daily weather. We noticed certain pitfalls that can lead to poor results ...when using clustering algorithms and have proposed some steps towards the solution. These advancements might prove interesting for climate informatics, as well as for many applications that cluster physical fields. We illustrated the pitfalls with a dataset of cumulative rainfall from NASA’s Tropical Rainfall Measuring Mission for the period 2000 to 2014. First, the pitfall is the lack of numerical evaluation of the clusters found by the algorithms, which prevents the comparison of algorithms. We used silhouette index for this evaluation and to demonstrate other problems. Second, algorithms like K-means cluster the points around their barycentre. For many physical fields, this barycentre is trivial, which may lead to poor performances. Third, the L2 norm used in conventional clustering methods, such as K-means and hierarchical agglomerative clustering, focus on the exact location of fields, which leads to poor evaluations of similarity between fields. We replaced it by a similarity measure called the expert distance (ED) that compares the histograms of four zones, based on the symmetrised Kullback–Leibler divergence. It integrates the properties of the observed physical parameter and climate knowledge. With these improvements, the results revealed five clusters with high indexes. The algorithms now discriminate the daily scenarios favourably, thereby providing more physical meaning to the resulting clusters. The interpretation of these clusters as weather types is discussed.
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•The use of L2 norm in clustering methods alters the results relevance for rainfalls.•A new pseudo-distance for clustering analysis based on prior knowledges is proposed.•Integration the pseudo-distance into the silhouette index to assess the clustering.•A local application on Lesser Antilles gives significant results.
Here, we report a novel experimental setup to perform adoptive transfer of gene-edited B cells using humanized immune system mice by infusing autologous HIS mouse-derived human B cells “educated” in ...a murine context and thus rendered tolerant to the host. The present approach presents two advantages over the conventional humanized PBMC mouse models: (i) it circumvents the risk of xenogeneic graft-versus-host reaction and (ii) it mimics more closely human immune responses, thus favoring clinical translation. We show that the frequencies and numbers of transduced B cells in recipient’s spleens one week post-transfer are within the range of the size of the pre-immune B cell population specific for a given protein antigen in the mouse. They are also compatible with the B cell numbers required to elicit a sizeable immune response upon immunization. Altogether, our findings pave the way for future studies aiming at assessing therapeutic interventions involving B cell reprogramming for instance by an antibody transgene in a “humanized” hematopoietic setting.
Biodiversity-based agriculture is the main form of agriculture practiced by smallholder farmers, who produce half the world’s food, especially in the Global South. This form of agriculture relies on ...planned biodiversity intentionally managed by farmers and on the associated biodiversity that spontaneously colonizes the agroecosystem. In recent decades, there have been increasing calls from researchers and society to support biodiversity-based agriculture as an alternative paradigm to today’s industrial agriculture. Building adapted governance and management systems for enhancing farmers’ access to agrobiodiversity is a key challenge for the development of biodiversity-based agriculture. To achieve this, a better understanding of how farmer’s access agrobiodiversity is needed, and in particular, how this access is affected by interactions between farmers and with institutions, i.e., social networks. In this article, we first review the literature on the role of social networks in farmers’ access to agrobiodiversity, in the form of crop diversity and associated biodiversity, and the related knowledge to manage this diversity. This review points at a major knowledge gap concerning how the composition and structure of these networks affect farmers’ access to agrobiodiversity. Then, we review literature on social-ecological networks to identify how this framework developed for environmental management could contribute in getting a better understanding of the role of social networks’ structure and composition in farmers’ access to agrobiodiversity. Based on this review, we propose a social-ecological network framework dedicated to crop diversity. Finally, we present potential applications of this framework to develop new participatory approaches for agrobiodiversity management and governance, adapted to biodiversity-based agriculture.
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