In conventional electron trapping optical storage phosphor, both short‐ and long‐wavelength light are needed for information write‐in and read‐out, respectively, complicating the optical storage ...system. Here, a Y3Al2Ga3O12:Pr3+,Eu3+ optical storage phosphor with Pr3+ as an electron donor and Eu3+ as an electron trap is designed, and a single wavelength write‐read scheme is demonstrated, which employs the same blue laser diode (LD) light source for both optical write‐in through two‐photon up‐conversion charging and for read‐out based on photostimulated luminescence (PSL), originated from 4f15d1→4f2 transition of Pr3+ peaked at 315 nm in UV region. A deep electron trap with the mean depth of 1.42 eV and a narrow distribution of 0.3 eV is observed in the presence of Eu3+ in Y3Al2Ga3O12:Pr3+, implying its long‐term storage potential. The write‐in and read‐out experiments are conducted using 450 nm blue LD light with the power density of 1 W cm−2 for write‐in and that with a low power density of 0.02 W cm−2 for read‐out in order to avoid the effect of up‐conversion luminescence on PSL signal. These results will advance the electron trapping optical storage scheme.
A novel optical storage scheme with two‐photon write‐in and one‐photon read‐out using a single‐wavelength light source is developed and demonstrated in Y3Al2Ga3O12:Pr3+,Eu3+ storage phosphor. Pr3+ and Eu3+ provide the energy‐level structure for two‐photon write‐in and deep traps for long‐term storage, respectively. This scheme simplifies conventional optical storage systems based on electron‐trapping media.
Deep traps are needed for electron‐trapping‐based long‐term optical storage due to its resistance to thermal erasure. Current electron trapping materials have the erasing temperatures hardly beyond ...600 K, limiting its storage time. Herein, an electron trapping material containing deep traps is achieved by co‐doping Tb and Eu in Y3Al5O12 via solid‐state reaction in reducing atmosphere. After 254 nm UV charging, strong thermoluminescence of Tb3+ with the glow curve peaking at 600, 693, and 765 K is observed. The comparative studies of the as‐made and the air‐annealed samples suggest that these new traps are related to the complex defects containing oxygen vacancy with adjacent Eu2+ and the charging process is the photoionization of Tb3+ with subsequent electron trapping. The 693 and 765 K thermoluminescence glow peaks in the charged sample show almost no decrease during 108 h storage in dark at room temperature. Images write‐in and read‐out via 808 nm laser stimulation are realized. Furthermore, the present phosphor also exhibits temperature‐sensitive afterglow spectra in the range of 553–803 K with the sensing span of 250 K wider than other afterglow thermometers. These findings indicate the great application potentials of Y3Al5O12:Tb,Eu phosphor in long‐term optical storage and temperature sensing.
Three deep electron trapping traps are created by co‐doping Tb and Eu into Y3Al5O12 under a reducing atmosphere. These traps exhibit thermoluminescence peaks greater than 600 K such that the release of trapped electrons can be suppressed at room temperature to achieve long‐term optical storage. These traps also exhibit a wide distribution such that wide‐range afterglow‐intensity‐ratio‐based temperature sensing is realized.
Nanowire solar cells: Pt nanoparticle (PtNP) decorated C/Si core/shell nanowire photoelectrochemical solar cells (see picture) show high conversion efficiency of 10.86 % and excellent stability in ...aggressive electrolytes under 1‐sun AM 1.5 G illumination. Superior device performance is achieved by improved surface passivation of the nanowires by carbon coating and enhanced interfacial charge transfer by PtNPs.
Introduction
AML patients with KMT2A‐MLLT3 and other 11q23 abnormalities belong to the intermediate and high‐risk level groups, respectively. Whether the poor prognostic value of Ecotropic Viral ...Integration site‐1 (EVI1) overexpression suits either the subtypes of KMT2A‐MLLT3 or Non‐KMT2A‐MLLT3 AML patients (intermediate and high risk group) needs to be further investigated.
Methods
We retrospectively analyzed the clinical characteristics of 166 KMT2A‐r and KMT2A‐PTD AML patients.
Results
For the Non‐KMT2A‐MLLT3 group, patients in the EVI1‐high subgroup had shorter OS and DFS and higher CIR than those in the EVI1‐low subgroup (p = .027, p = .018, and p = .020, respectively). Additionally, both KMT2A‐MLLT3 and Non‐KMT2A‐MLLT3 patients who received chemotherapy alone had poorer prognosis than patients who also received allogeneic hematopoietic stem cell transplant (allo‐HSCT) regardless of their EVI1 expression level (all p < .001). For transplanted patients with KMT2A‐MLLT3 or Non‐KMT2A‐MLLT3 rearrangement, the EVI1‐high subgroup had worse prognosis than the EVI1‐low subgroup (all p < .05). The 2‐year CIR of the KMT2A‐MLLT3 and Non‐KMT2A‐MLLT3 groups with high EVI1 expression was high (52% and 49.6%, respectively). However, for patients with low EVI1 expression, the 2‐year CIR of transplanted patients with KMT2A‐MLLT3 and Non‐KMT2A‐MLLT3 was relatively low.
Conclusions
Our study showed that for the Non‐KMT2A‐MLLT3 group, the EVI1‐high group had shorter OS and DFS than the EVI1‐low group. High EVI1 expression showed an adverse effect in AML with KMT2A rearrangement in different risk stratification subtypes. For the EVI1‐high patients with non‐KMT2A‐MLLT3 rearrangement, other novel regimens towards relapse should be taken into consideration.
Objective The study goal was to determine the diagnostic accuracy of a specific cytokine pattern including interferon-gamma (IFN-γ), interleukin (IL)-10, and IL-6 for hemophagocytic ...lymphohistiocytosis (HLH) in febrile children. Study design In this prospective study, 756 patients with fever admitted to a hematology-oncology unit were enrolled. The causes of fever were documented and the serum cytokines, including IFN-γ, tumor necrosis factor-alpha (TNF-α), IL-10, IL-6, IL-4, and IL-2, were determined using cytometric bead array techniques. Results Of 1474 episodes of fever that were analyzed, 71 episodes of HLH manifested a specific cytokine pattern of highly increased levels of IFN-γ (median level: 1088.5 pg/mL) and IL-10 (623.5 pg/mL) but a moderately increased level of IL-6 (51.1 pg/mL). IL-6 was predominantly increased to varied extents in patients in the sepsis group (244.6 pg/mL) and the nonsepsis infection group (34.7 pg/mL). The diagnostic accuracy of IFN-γ and IL-10 for HLH was 99.5% and 92.8%, respectively. By applying the cutoff point of 100 pg/mL, IFN-γ had a sensitivity of 94.4% and a specificity of 97.2% for HLH. When using the criteria of IFN-γ >75 pg/mL and IL-10 >60 pg/mL, the specificity reached 98.9% and the sensitivity was 93.0%. Conclusions The specific cytokine pattern of markedly elevated levels of IFN-γ and IL-10 with only modestly elevated IL-6 levels has high diagnostic accuracy for HLH and may be a useful approach to differentiate HLH from infection.
A solvent–non-solvent approach was used to create a CL-20-based aluminum-containing explosive with a composite structure. The SEM results demonstrate that the aluminum powder is equally embedded on ...the surface of the CL-20 crystal in the CL-20/Al explosive with a composite structure but the aluminum powder in the mechanically mixed CL-20/Al explosive is agglomerated and spread unevenly. The maximum expansion velocity of the composite structure CL-20/Al explosive was 17.74% higher than that of the mechanically mixed explosive in the cylinder test, and the acceleration ability of the CL-20/Al explosive with a composite structure to the cylinder wall is superior to that of the mechanically mixed explosive. In the air explosion test, the shock wave overpressure and impulse of the CL-20/Al explosive with a composite structure are superior to those of the mechanically mixed explosive, but as the distance increases, the gap between the two explosives gradually narrows until it is flat. The results of interfacial particle velocity show that the length of the reaction zone and duration of CL-20/Al explosives with composite structures are longer than those of mechanically mixed structures, and the interfacial particle velocity of CL-20/Al explosives with composite structures is higher than that of mechanically mixed structures.
Summary
Data from 200 children with high‐risk acute myeloid leukaemia who underwent their first haploidentical haematopoietic stem cell transplantation (haplo‐HSCT) between 2015 and 2021 at our ...institution were analysed. The 4‐year overall survival (OS), event‐free survival (EFS) and cumulative incidence of relapse (CIR) were 71.9%, 62.3% and 32.4% respectively. The 100‐day cumulative incidences of grade II–IV and III–IV acute graft‐versus‐host disease (aGVHD) were 41.1% and 9.5% respectively. The 4‐year cumulative incidence of chronic GVHD (cGVHD) was 56.1%, and that of moderate‐to‐severe cGVHD was 27.3%. Minimal residual disease (MRD)‐positive (MRD+) status pre‐HSCT was significantly associated with lower survival and a higher risk of relapse. The 4‐year OS, EFS and CIR differed significantly between patients with MRD+ pre‐HSCT (n = 97; 63.4%, 51.4% and 41.0% respectively) and those with MRD‐negative (MRD‐) pre‐HSCT (n = 103; 80.5%, 73.3% and 23.8% respectively). Multivariate analysis also revealed that acute megakaryoblastic leukaemia without Down syndrome (non‐DS‐AMKL) was associated with extremely poor outcomes (hazard ratios and 95% CIs for OS, EFS and CIR: 3.110 (1.430–6.763), 3.145 (1.628–6.074) and 3.250 (1.529–6.910) respectively; p‐values were 0.004, 0.001 and 0.002 respectively). Thus, haplo‐HSCT can be a therapy option for these patients, and MRD status pre‐HSCT significantly affects the outcomes. As patients with non‐DS‐AMKL have extremely poor outcomes, even with haplo‐HSCT, a combination of novel therapies is urgently needed.
Data on 200 pediatric patients with high risk AML reveals that unmanipulated haplo‐HSCT has the potential to enhance the chances of recovery. Moreover, the status of minimal residual disease (MRD) pre‐HSCT significantly influences the treatment outcomes.
Purpose
This study aimed to evaluate the factors associated with bilateral papillary thyroid carcinoma (PTC) and lateral cervical lymph node metastasis (LLNM) in patients with suspicious unilateral ...PTC.
Methods
This study analyzed patients with suspicious unilateral PTC who were enrolled in a university hospital between 2016 and 2019 in Zhejiang, China. Using logistic regression, the study examined the factors associated with bilateral PTC and LLNM in demographic data, anthropometric measurements, lifestyle factors, medical history, preoperative diagnostic tests, and histopathological factors.
Results
A total of 256 patients, with a mean age of 49 years, were enrolled. Bilateral PTC was associated with multifocality (aOR: 5.069, 95% CI: 2.440–10.529,
P
< 0.001), and contralateral nodule in the upper (aOR: 9.073, 95% CI: 2.111–38.985,
P
= 0.003) and middle (aOR: 9.926, 95% CI: 2.683–36.717,
P
< 0.001). LLNM was positively associated with bilateral PTC (aOR, 4.283, 95% CI: 1.378–13.308,
p
= 0.012), male (aOR, 3.377, 95% CI: 1.205–9.461,
P
= 0.021), upper location of carcinoma (aOR, 3.311, 95% CI: 1.091–10.053,
p
= 0.035), and punctate echogenic foci (aOR, 3.309, 95% CI: 1.165–9.394,
P
= 0.025). Contralateral maximal nodule in the upper (aOR: 0.098, 95% CI: 0.015–0.628,
p
= 0.014), middle (aOR: 0.114, 95% CI: 0.033–0.522,
p
< 0.001), and lower (aOR, 0.028, 95% CI: 0.003–0.276,
P
= 0.002) location were inversely associated with LLNM.
Conclusion
Upper and middle location of contralateral nodule and tumor multifocality predicted the risk bilateral PTC. Bilateral PTC, male, upper tumor location, punctate echogenic foci and contralateral nodule location in the entire lobes were independent predictors for LLNM.
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