The aim of this study is to carry out a taxonomic revision of the groups Calamistratum and Geraniodorum of the genus Inosperma sect. Inosperma in Europe. For this purpose, a multigenic phylogenetic ...analysis was carried out using the ITS, LSU, RPB1 and RPB2 markers, covering a total of 111 sequences, including those generated from the existing type-material collections. This analysis led to the recognition of nine clades or terminal groups for the European continent, correlating with nine morphological species. Three of them, I. calamistratum, I. neohirsutum sp. nov. and I. turietoense sp. nov., are distributed in humid and temperate forests, whereas I. geminum sp. nov., I. geraniodorum, I. gracilentum sp. nov., I. praetermissum comb. nov., I. subhirsutum and I. veliferum seem to be restricted to the colder altimontane, boreal and alpine climates. It is concluded that the study of morphological and ecological characteristics allows the recognition of species without the need for an often-subjective interpretation of organoleptic characteristics. Inocybe hirsuta is considered a synonym of Inosperma calamistratum, Inosperma praetermissum as a different species from I. calamistratum, and Inocybe geraniodora var. gracilenta f. salicis-herbaceae as a synonym of I. praetermissum. Four new species and one new combination are proposed. A key for the recognition of the European species is provided. Illustrations and photographs of macro- and micromorphological characters and SEM spores of all species are presented.
This article is the 15th contribution in the Fungal Diversity Notes series, wherein 115 taxa from three phyla, nine classes, 28 orders, 48 families, and 64 genera are treated. Fungal taxa described ...and illustrated in the present study include a new family, five new genera, 61 new species, five new combinations, one synonym, one new variety and 31 records on new hosts or new geographical distributions. Ageratinicolaceae
fam. nov.
is introduced and accommodated in Pleosporales. The new genera introduced in this study are
Ageratinicola
,
Kevinia
,
Pseudomultiseptospora
(Parabambusicolaceae),
Marasmiellomycena
, and
Vizzinia
(Porotheleaceae). Newly described species are
Abrothallus altoandinus
,
Ageratinicola kunmingensis
,
Allocryptovalsa aceris
,
Allophoma yuccae
,
Apiospora cannae
,
A. elliptica
,
A. pallidesporae
,
Boeremia wisteriae
,
Calycina papaeana
,
Clypeococcum lichenostigmoides
,
Coniochaeta riskali-shoyakubovii
,
Cryphonectria kunmingensis
,
Diaporthe angustiapiculata
,
D. campylandrae
,
D. longipapillata
,
Diatrypella guangdongense
,
Dothiorella franceschinii
,
Endocalyx phoenicis
,
Epicoccum terminosporum
,
Fulvifomes karaiensis
,
F. pannaensis
,
Ganoderma ghatensis
,
Hysterobrevium baoshanense
,
Inocybe avellaneorosea
,
I. lucida
,
Jahnula oblonga
,
Kevinia lignicola
,
Kirschsteiniothelia guangdongensis
,
Laboulbenia caprina
,
L. clavulata
,
L. cobiae
,
L. cosmodisci
,
L. nilotica
,
L. omalii
,
L. robusta
,
L. similis
,
L. stigmatophora
,
Laccaria rubriporus
,
Lasiodiplodia morindae
,
Lyophyllum agnijum
,
Marasmiellomycena pseudoomphaliiformis
,
Melomastia beihaiensis
,
Nemania guangdongensis
,
Nigrograna thailandica
,
Nigrospora ficuum
,
Oxydothis chinensis
,
O. yunnanensis
,
Petriella thailandica
,
Phaeoacremonium chinensis
,
Phialocephala chinensis
,
Phytophthora debattistii
,
Polyplosphaeria nigrospora
,
Pronectria loweniae
,
Seriascoma acutispora
,
Setoseptoria bambusae
,
Stictis anomianthi
,
Tarzetta tibetensis
,
Tarzetta urceolata
,
Tetraploa obpyriformis
,
Trichoglossum beninense
, and
Tricoderma pyrrosiae
. We provide an emendation for
Urnula ailaoshanensis Agaricus duplocingulatoides
var.
brevisporus
introduced as a new variety based on morphology and phylogeny.
Abstract A non-synonymous genetic rare variant, rs75932628-T (p.R47H), in the TREM2 gene has recently been reported to be a strong genetic risk factor for Alzheimer's disease (AD). Also, rare ...recessive mutations have been associated with frontotemporal dementia (FTD). We aimed to investigate the role of p.R47H variant in AD and FTD through a multi-center study comprising 3172 AD and 682 FTD patients and 2169 healthy controls from Spain. We found that 0.6% of AD patients carried this variant compared to 0.1% of controls (odds ratio OR = 4.12, 95% confidence interval CI = 1.21–14.00, p = 0.014). A meta-analysis comprising 32,598 subjects from 4 previous studies demonstrated the large effect of the p.R47H variant in AD risk (OR = 4.11, 95% CI = 2.99–5.68, p = 5.27×10−18 ). We did not find an association between p.R47H and age of onset of AD or family history of dementia. Finally, none of the FTD patients harbored this genetic variant. These data strongly support the important role of p.R47H in AD risk, and suggest that this rare genetic variant is not related to FTD.
The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with ...frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls). Additionally, we included 101 individuals from 21 families with genetic FTD. MAPT p.A152T was borderline significantly associated with FTD odds ratio (OR) = 2.03; p = 0.063, but not with AD. MAPT H1 haplotype was associated with AD risk (OR = 1.12; p = 0.0005). Stratification analysis showed that this association was mainly driven by APOE ɛ4 noncarriers (OR = 1.14; p = 0.0025). MAPT H1 was also associated with risk for PD (OR = 1.30; p = 0.0003) and PSP (OR = 3.18; p = 8.59 × 10-8) but not FTD. Our results suggest that the MAPT H1 haplotype increases the risk of PD, PSP, and non-APOE ɛ4 AD.
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