Provider: - Institution: Gredos. Repositorio Documental de la Universidad de Salamanca - Data provided by Europeana Collections- ENBackground: MicroRNAs are known to inhibit gene expression by ...binding to the 3′UTR of the target transcript. Downregulation of miR-223 has been recently reported to have prognostic significance in CLL. However, there is no evidence of the pathogenetic mechanism of this miRNA in CLL patients. Methods: By applying next-generation sequencing techniques we have detected a common polymorphism (rs2307842), in 24% of CLL patients, which disrupts the binding site for miR-223 in HSP90B1 3′UTR. We investigated whether miR-223 directly targets HSP90B1 through luciferase assays and ectopic expression of miR-223. Quantitative real-time polymerase chain reaction and western blot were used to determine HSP90B1 expression in CLL patients. The relationship between rs2307842 status, HSP90B1 expression and clinico-biological data were assessed. Results: HSP90B1 is a direct target for miR-223 by interaction with the putative miR-223 binding site. The analysis in paired samples (CD19+ fraction cell and non-CD19+ fraction cell) showed that the presence of rs2307842 and IGHV unmutated genes determined HSP90B1 overexpression in B lymphocytes from CLL patients. These results were confirmed at the protein level by western blot. Of note, HSP90B1 overexpression was independently predictive of shorter time to the first therapy in CLL patients. By contrast, the presence of rs2307842 was not related to the outcome. Conclusions: HSP90B1 is a direct target gene of miR-223. Our results provide a plausible explanation of why CLL patients harboring miR-223 downregulation are associated with a poor outcome, pointing out HSP90B1 as a new pathogenic mechanism in CLL and a promising therapeutic target.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Fragmenta Chorologica Occidentale Javier Cremades; Ignacio Bárbara; Alberto Granja ...
Anales del Jardín Botánico de Madrid (1979),
12/1997, Letnik:
55, Številka:
2
Journal Article
Provider: - Institution: Gredos. Repositorio Documental de la Universidad de Salamanca - Data provided by Europeana Collections- Memoria ID-030. Ayudas de la Universidad de Salamanca para la ...innovación docente, curso 2010-2011.- Mediante el proyecto “Arquitectura de comunicación e interacción basada en estándares de calidad para la comunidad universitaria”, la comunicación entre los miembros de la Facultad de Ciencias se ha agilizado. Las actividades que se llevaron a cabo para el desarrollo del proyecto fueron las establecidas en la propuesta inicial. Como conclusión podemos decir que el desarrollo e implantación de la arquitectura ha cubierto exitosamente los objetivos planteados en la propuesta inicial pues se han logrado los resultados esperados.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Gredos. Repositorio Documental de la Universidad de Salamanca - Data provided by Europeana Collections- Memoria ID-0019. Ayudas de la Universidad de Salamanca para la ...Innovación Docente, curso 2008-2009.- El proyecto Formación y tutorización activa mediante Web 3D, ha permitido poner en marcha el portal fcienciasvirtual.usal.es en el que se presenta un mundo virtual de la Facultad de Ciencias. La Web 3D de la facultad de ciencias facilita la interacción entre estudiantes y profesores y es una herramienta de soporte a la docencia. Se trata de un entorno inmersivo 3D, adaptado a la Facultad y de tipo experimental.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Artisanal coastal invertebrate fisheries in Galicia are socio-economically important and ecologically relevant. Theirmanagement, however, has been based on models of fish population dynamics ...appropriate for highly mobile demersalor pelagic resources and for industrial fisheries. These management systems focus on regulating fishing effort,but in coastal ecosystems activities that change or destruct key habitats may have a greater effect on populationabundance than does fishing mortality. The Golfo Artabro was analysed as a representative example of a coastalecosystem in Galicia, and the spider crab "Maja squinado" used as a model of an exploited coastal invertebrate,for which shallow coastal areas are key habitats for juvenile stages. The commercial legal gillnet fishery for thespider crab harvests adults during their reproductive migrations to deep waters and in their wintering habitats.Illegal fisheries operate in shallow waters. The annual rate of exploitation is higher to 90%, and lower to 10% of the primiparousfemales reproduce effectively at least once. A simple spatially-explicit cohort model was constructed to simulatethe population dynamics of spider crab females. Yield- and egg-per-recruit analyses corresponding to differentexploitation regimes were performed to compare management policies directed to control the fishing effort orto protect key habitats. It was found that the protection of juvenile habitats could allow increases in yield andreproductive effort higher than in the present system, with such protection based in the control of the fishing effortof the legal fishery. Additionally, there is an urgent need for alternative research and management strategies inartisanal coastal fisheries based on the implementation of a system of territorial use rights for fishers, the integrationof the fishers into assessment and management processes, and the protection of key habitats (marine reserves) as abasic tool for the regulation of the fisheries.
Consellería de Educación e Ordenación Universitaria (XUGA10301B97, Xunta de Galicia
Artisanal coastal invertebrate fisheries in Galicia are socio-economically important and ecologically relevant. Theirmanagement, however, has been based on models of fish population dynamics ...appropriate for highly mobile demersalor pelagic resources and for industrial fisheries. These management systems focus on regulating fishing effort,but in coastal ecosystems activities that change or destruct key habitats may have a greater effect on populationabundance than does fishing mortality. The Golfo Artabro was analysed as a representative example of a coastalecosystem in Galicia, and the spider crab "Maja squinado" used as a model of an exploited coastal invertebrate,for which shallow coastal areas are key habitats for juvenile stages. The commercial legal gillnet fishery for thespider crab harvests adults during their reproductive migrations to deep waters and in their wintering habitats.Illegal fisheries operate in shallow waters. The annual rate of exploitation is higher to 90%, and lower to 10% of the primiparousfemales reproduce effectively at least once. A simple spatially-explicit cohort model was constructed to simulatethe population dynamics of spider crab females. Yield- and egg-per-recruit analyses corresponding to differentexploitation regimes were performed to compare management policies directed to control the fishing effort orto protect key habitats. It was found that the protection of juvenile habitats could allow increases in yield andreproductive effort higher than in the present system, with such protection based in the control of the fishing effortof the legal fishery. Additionally, there is an urgent need for alternative research and management strategies inartisanal coastal fisheries based on the implementation of a system of territorial use rights for fishers, the integrationof the fishers into assessment and management processes, and the protection of key habitats (marine reserves) as abasic tool for the regulation of the fisheries.
Consellería de Educación e Ordenación Universitaria (XUGA10301B97, Xunta de Galicia
Artisanal coastal invertebrate fisheries in Galicia are socio-economically important and ecologically relevant. Theirmanagement, however, has been based on models of fish population dynamics ...appropriate for highly mobile demersalor pelagic resources and for industrial fisheries. These management systems focus on regulating fishing effort,but in coastal ecosystems activities that change or destruct key habitats may have a greater effect on populationabundance than does fishing mortality. The Golfo Artabro was analysed as a representative example of a coastalecosystem in Galicia, and the spider crab "Maja squinado" used as a model of an exploited coastal invertebrate,for which shallow coastal areas are key habitats for juvenile stages. The commercial legal gillnet fishery for thespider crab harvests adults during their reproductive migrations to deep waters and in their wintering habitats.Illegal fisheries operate in shallow waters. The annual rate of exploitation is higher to 90%, and lower to 10% of the primiparousfemales reproduce effectively at least once. A simple spatially-explicit cohort model was constructed to simulatethe population dynamics of spider crab females. Yield- and egg-per-recruit analyses corresponding to differentexploitation regimes were performed to compare management policies directed to control the fishing effort orto protect key habitats. It was found that the protection of juvenile habitats could allow increases in yield andreproductive effort higher than in the present system, with such protection based in the control of the fishing effortof the legal fishery. Additionally, there is an urgent need for alternative research and management strategies inartisanal coastal fisheries based on the implementation of a system of territorial use rights for fishers, the integrationof the fishers into assessment and management processes, and the protection of key habitats (marine reserves) as abasic tool for the regulation of the fisheries.
Consellería de Educación e Ordenación Universitaria (XUGA10301B97, Xunta de Galicia
Procédese á revisión dos traballos de prospección previa na serra do Barbanza e ampliados aos montes de Macenda e Bealo na procura de asentamentos gandeiros/pastorís, no curso deses traballos ...localizáronse ademáis un interesante xacemento de cronoloxía calcolítca e un castro inédito. Asemade, dáse conta dos resultados das intervencións en dous xacementos, un de carácter gandeiro que presenta un palimpsesto estrutural e cronolóxico (Río Barbanza), e outro relacionado con sistemas de control territorial (Outeiro da Torre).
España es plural: Una encuesta con matices Luna, Fernando Agullera; Asensio, Pilar; Zurita, M. Goya Asín ...
El Ciervo,
03/2007, Letnik:
56, Številka:
672
Magazine Article
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