The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming ...increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology have convened to establish this Brazilian Consensus for the Treatment of MS, based on their understanding that neurologists should be able to prescribe MS DMTs according to what is better for each patient, based on up-to-date evidence and practice. We herein propose practical recommendations for the treatment of MS, with the main focus on the choice and management of DMTs, as well as present a review of the scientific rationale supporting therapeutic strategies in MS.
Here, we present angular diameter measurements obtained by measuring the position of baryon acoustic oscillations (BAO) in an optimized sample of galaxies from the first three years of Dark Energy ...Survey data (DES Y3). The sample consists of 7 million galaxies distributed over a footprint of 4100 deg2 with 0.6 < z photo < 1.1 and a typical redshift uncertainty of 0.03(1 + z). The sample selection is the same as in the BAO measurement with the first year of DES data, but the analysis presented here uses three times the area, extends to higher redshift, and makes a number of improvements, including a fully analytical BAO template, the use of covariances from both theory and simulations, and an extensive preunblinding protocol. We used two different statistics; angular correlation function and power spectrum, and validate our pipeline with an ensemble of over 1500 realistic simulations. Both statistics yield compatible results. We combine the likelihoods derived from angular correlations and spherical harmonics to constrain the ratio of comoving angular diameter distance DM at the effective redshift of our sample to the sound horizon scale at the drag epoch. We obtain DM(z eff = 0.835 )/rd = 18.92 ± 0.51, which is consistent with, but smaller than, the Planck prediction assuming flat Λ CDM , at the level of 2.3σ. The analysis was performed blind and is robust to changes in a number of analysis choices. It represents the most precise BAO distance measurement from imaging data to date, and is competitive with the latest transverse ones from spectroscopic samples at z > 0.75. When combined with DES 3x2pt + SNIa, they lead to improvements in H0 and Ωm constraints by ~20 %.
This work, together with its companion paper, Secco and Samuroff et al. (2021), presents the Dark Energy Survey Year 3 cosmic shear measurements and cosmological constraints based on an analysis of ...over 100 million source galaxies. With the data spanning 4143 deg2 on the sky, divided into four redshift bins, we produce the highest significance measurement of cosmic shear to date, with a signal-to-noise of 40. We conduct a blind analysis in the context of the ΛCDM model and find a 3% constraint of the clustering amplitude, S8≡σ8(Ωm/0.3)0.5=0.759+0.025-0.023. A ΛCDM-Optimized analysis, which safely includes smaller scale information, yields a 2% precision measurement of S8=0.772+0.018-0.017 that is consistent with the fiducial case. The two low-redshift measurements are statistically consistent with the Planck Cosmic Microwave Background result, however, both recovered S8 values are lower than the high-redshift prediction by 2.3σ and 2.1σ (p-values of 0.02 and 0.05), respectively. The measurements are shown to be internally consistent across redshift bins, angular scales and correlation functions. The analysis is demonstrated to be robust to calibration systematics, with the S8 posterior consistent when varying the choice of redshift calibration sample, the modeling of redshift uncertainty and methodology. Similarly, we find that the corrections included to account for the blending of galaxies shifts our best-fit S8 by 0.5σ without incurring a substantial increase in uncertainty. We examine the limiting factors for the precision of the cosmological constraints and find observational systematics to be subdominant to the modeling of astrophysics. Specifically, we identify the uncertainties in modeling baryonic effects and intrinsic alignments as the limiting systematics.
The genus Lippia (Verbenaceae) comprises about 200 taxa mainly distributed in Brazil, Mexico, Central America, Africa, Argentina and Paraguay. Some problems involving the number and delimitation of ...species have been reported. In order to contribute to the solving of these problems, the chromosome numbers of 14 Lippia species are documented. The following species were collected at Espinhaço Range, Southeast Brazil: Section Zapania (L. corymbosa, L. diamantinensis, L. hermannioides, L. lacunosa, L. rotundifolia, L. rubella), section Rhodolippia (L. florida, L. lupulina, L. pseudothea, L. rosella), section Goniostlachyum (L. glandulosa, L. pohliana, L. sidoides) and section Dioicolippia (L.filifolia). Immature inflorescences were collected and the ideal size for chromosome observation was determined. The majority of species have a haploid chromosome number from 10 to 14. Few species have a higher chromosome number, which suggests the occurrence of polyploidy. The relationships between chromosome numbers and the taxonomic sections are also discussed.
Obesity is believed to be a risk factor for COVID-19 and unfavorable outcomes, although data on this remains to be better elucidated.
To evaluate the impact of obesity on the endpoints of patients ...hospitalized due to SARS-CoV-2.
This retrospective cohort study evaluated patients hospitalized at a tertiary hospital (Hospital das Clínicas da Faculdade de Medicina da USP) from March to December 2020. Only patients positive for COVID-19 (real-time PCR or serology) were included. Data were collected from medical records and included clinical and demographic information, weight and height, SAPS-3 score, comorbidities, and patient-centered outcomes (mortality, and need for mechanical ventilation, renal replacement therapy, or vasoactive drugs). Patients were divided into categories according to their BMI (underweight, eutrophic, overweight and obesity) for comparison porpoise.
A total of 2547 patients were included. The mean age was 60.3 years, 56.2% were men, 65.2% were white and the mean BMI was 28.1 kg/m
. SAPS-3 score was a risk factor for all patient-centered outcomes (HR 1.032 for mortality, OR 1.03 for dialysis, OR 1.07 for vasoactive drug use, and OR 1.08 for intubation, p < 0.05). Male sex increased the risk of death (HR 1.175, p = 0.027) and dialysis (OR 1.64, p < 0.001), and underweight was protective for vasoactive drug use (OR 0.45, p = 0.027) and intubation (OR 0.31, p < 0.003).
Obesity itself was not an independent factor for worse patient-centered outcomes. Critical clinical state (indirectly evaluated by SAPS-3) appears to be the most important variable related to hard outcomes in patients infected with COVID-19.
The differential charged jet cross sections, jet fragmentation distributions, and jet shapes are measured in minimum bias proton-proton collisions at centre-of-mass energy $\sqrt{s}=7$ TeV using the ...ALICE detector at the LHC. Jets are reconstructed from charged particle momenta in the mid-rapidity region using the sequential recombination $k_{\rm T}$ and anti-$k_{\rm T}$ as well as the SISCone jet finding algorithms with several resolution parameters in the range $R=0.2$ to $0.6$. Differential jet production cross sections measured with the three jet finders are in agreement in the transverse momentum ($p_{\rm T}$) interval $20<p_{\rm T}^{\rm jet,ch}<100$ GeV/$c$. They are also consistent with prior measurements carried out at the LHC by the ATLAS collaboration. The jet charged particle multiplicity rises monotonically with increasing jet $p_{\rm T}$, in qualitative agreement with prior observations at lower energies. The transverse profiles of leading jets are investigated using radial momentum density distributions as well as distributions of the average radius containing 80% ($\langle R_{\rm 80} \rangle$) of the reconstructed jet $p_{\rm T}$. The fragmentation of leading jets with $R=0.4$ using scaled $p_{\rm T}$ spectra of the jet constituents is studied. The measurements are compared to model calculations from event generators (PYTHIA, PHOJET, HERWIG). The measured radial density distributions and $\langle R_{\rm 80} \rangle$ distributions are well described by the PYTHIA model (tune Perugia-2011). The fragmentation distributions are better described by HERWIG.
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