ABSTRACT
We report on the Imaging X-ray Polarimetry Explorer (IXPE) observation of the closest and X-ray brightest Compton-thick active galactic nucleus (AGN), the Circinus galaxy. We find the source ...to be significantly polarized in the 2–6 keV band. From previous studies, the X-ray spectrum is known to be dominated by reflection components, both neutral (torus) and ionized (ionization cones). Our analysis indicates that the polarization degree is 28 ± 7 per cent (at 68 per cent confidence level) for the neutral reflector, with a polarization angle of 18° ± 5°, roughly perpendicular to the radio jet. The polarization of the ionized reflection is unconstrained. A comparison with Monte Carlo simulations of the polarization expected from the torus shows that the neutral reflector is consistent with being an equatorial torus with a half-opening angle of 45°–55°. This is the first X-ray polarization detection in a Seyfert galaxy, demonstrating the power of X-ray polarimetry in probing the geometry of the circumnuclear regions of AGNs, and confirming the basic predictions of standard Unification Models.
Anti-thymocyte globulin (ATG) is polyclonal, containing Ab specificities capable of binding to various immune-cell subsets implicated in the pathogenesis of GVHD, including T cells, B cells, natural ...killer cells, monocytes/macrophages, neutrophils and DC. We wished to determine which ATG specificities are important for GVHD prevention. We measured day 7 serum levels of 23 ATG specificities in 120 hematopoietic cell transplant recipients whose myeloablative conditioning included 4.5 mg/kg ATG (thymoglobulin). High levels of ATG specificities capable of binding to T- and B-cell subsets were associated with a low likelihood of acute GVHD (aGVHD). High levels of these ATG specificities were associated with increased rates of viral but not bacterial or fungal infections. They were not associated with an increased risk of malignancy relapse; on the contrary, high levels of ATG specificities capable of binding to regulatory T cells and invariant NKT cells were associated with a low risk of relapse. In conclusion, high levels of ATG antibodies to Ag(s) expressed on T and B cells are associated with a low risk of aGVHD and a high risk of viral but not bacterial or fungal infections. These antibodies have neutral or beneficial effects on relapse.
ABSTRACT
We present a broad analysis of X-ray polarimetric observational prospects for radio-quiet active galactic nuclei (AGN), focusing on the role of parsec-scale components. We provide a revision ...of self-consistent type-1 and type-2 generic AGN radiative transfer models that were obtained with a Monte Carlo code stokes, evaluating the effects of absorption and scattering. Our model consists of a central disc–corona emission obtained with the kynstokes code in the lamp-post geometry, an equatorial wedge-shaped dusty torus and two symmetric conical polar outflows. We argue that the information on the mutual orientation, shape, relative size, and composition of such components, usually obtained from spectroscopy or polarimetry in other wavelengths, is essential for the X-ray polarization analysis of the obscured type-2 AGNs. We provide general detectability prospects for AGNs with 2–8 keV polarimeters onboard of the currently flying Imaging X-ray Polarimetry Explorer (IXPE) satellite and the forthcoming enhanced X-ray Timing and Polarimetry mission. Finally, we assess the role of contemporary X-ray polarimetry in our understandings of the unified AGN model after the first year and a half of IXPE operation.
ABSTRACT
We present the expected X-ray polarization signal resulting from distant reprocessing material around black holes. Using a central isotropic power-law emission at the centre of the simulated ...model, we add distant equatorial and axially symmetric media that are covering the central accreting sources. We include partial ionization and partial transparency effects, and the impact of various polarization and steepness of the primary radiation spectrum. The results are obtained with the Monte Carlo code STOKES that considers both line and continuum processes and computes the effects of scattering and absorption inside static homogenous wedge-shaped and elliptical toroidal structures, varying in relative size, composition and distance to the source. We provide first order estimates for parsec-scale reprocessing in Compton-thin and Compton-thick active galactic nuclei, as well as winds around accreting stellar-mass compact objects, for observer’s inclinations above and below the grazing angle. The resulting reprocessed polarization can reach tens of per cent with either parallel or perpendicular orientation with respect to the axis of symmetry, depending on subtle details of the geometry, density, and ionization structure. We also show how principal parameters constrained from X-ray spectroscopy or polarimetry in other wavelengths can lift the shown degeneracies in X-ray polarization. We provide an application example of the broad modelling discussion by revisiting the recent IXPE 2–8 keV X-ray polarimetric observation of the accreting stellar-mass black hole in Cygnus X-3 from the perspective of partial transparency and ionization of the obscuring outflows.
ABSTRACT
X-ray polarimetric missions planned for this decade will significantly enhance our knowledge of compact accreting sources. Observations of the X-ray polarization signal from active galactic ...nuclei (AGNs) or X-ray binary systems (XRBs) will bring new means to study inner accretion flow in these objects that, together with currently used spectroscopic and timing techniques, will help us to determine better their properties, such as their inclination, orientation, shape, and size of their corona as well as the black hole spin. In this work, we present a yet missing piece in the global polarization models of black hole accretion discs. We compute the reflected X-ray emission from the disc in a local co-moving frame using (1) the radiative transfer code titan to obtain the ionization structure of the disc and (2) the Monte Carlo code stokes that incorporates the physics of absorption, re-emission, and Compton scattering to produce a complete spectropolarimetric output. We present the final Stokes parameters I, Q, and U for a set of photon-indices of the incident primary power-law radiation, the disc ionization parameters, incident and emission angles, for three independent polarization states of the incident coronal X-ray photons with a sufficient resolution in energy to allow for sharp discussion of spectral and polarization properties. We show that the spectral component matches well literature predictions. The polarization degree and angle are in agreement with analytical approximations previously appearing in reflection models and we demonstrate that the polarized reflected X-ray emission can be, locally, quite large in the $2{\!-\!}12\,$ keV band.
Abstract Introduction Parkinson's disease (PD) is neurodegenerative movement disorder affecting primarily the central nervous system with several recognized non-motor symptoms that can occur at ...various stages of the disease. Recently it has been shown that patients with PD may be prone to peripheral nervous system pathology in the form of a peripheral neuropathy (PN). It is unclear if PN is an inherent feature of PD or if it is an iatrogenic effect of the mainstay PD treatment Levodopa. Methods To determine if peripheral neuropathy occurs in early untreated PD we employed a case-control study design using gold standard tests for PN, including neurological examination according to the Utah Early Neuropathy Scale (UENS) and nerve conduction studies, as well as new, more sensitive and informative tests for PN including the skin biopsy and corneal confocal microscopy (CCM). Results We studied 26 patients with PD and 22 controls using the neurological examination and nerve conduction studies (NCS) and found no significant difference between groups except for some reduced vibration sense in the PD group. Epidermal nerve densities in the skin biopsies were similar between our cohorts. However, using CCM – a more sensitive test and a surrogate marker of small fiber damage in PN, we found that patients with PD had significantly reduced corneal nerve fiber densities and lengths as compared to controls. Conclusions We conclude that our positive CCM results provide evidence of preclinical PN in newly diagnosed PD patients.
ABSTRACT
Rebirth of X-ray polarimetric instruments will have a significant impact on our knowledge of compact accreting sources. The properties of inner-accreting regions of active galactic nuclei ...(AGNs) or X-ray binary systems, such as black-hole spin, their disc inclination and orientation, shape, and size of their corona, can be polarimetrically studied, parallelly to the well-known X-ray spectroscopic and timing techniques. In this work, we provide a new spectropolarimetric numerical estimate of X-rays in the lamp-post coronal model for a distant observer, including a polarized reflected radiation from the accretion disc. The local disc reflection was simulated using the codes titan and stokes and includes variable disc ionization as well as Monte Carlo treatment of Compton multiple scatterings. We introduce a relativistic code kynstokes based on our well-tested KY package that accounts for all relativistic effects on radiation near a black hole, apart from the returning radiation, and adds a possibility of polarized coronal emission. We study the spectrum, polarization degree and polarization angle at spatial infinity for various global system parameters and we demonstrate the difference at infinity, if analytical local reflection computations are used. We newly predict that in the hard X-rays the reflected component can be 25 per cent polarized and the total emission can be 9 per cent polarized in the most favourable, yet realistic configurations of radio-quiet AGNs. Thus, the relativistic disc reflection remains important for the interpretation of X-ray polarimetric observations.
ABSTRACT We present a series of numerical models suitable for X-ray polarimetry of accreting systems. First, we provide a spectropolarimetric routine that integrates reflection from inner optically ...thick walls of a geometrical torus of arbitrary size viewed under general inclination. In the studied example, the equatorial torus is illuminated by a central isotropic source of X-ray power-law emission, representing a hot corona. Nearly neutral reprocessing inside the walls is precomputed by Monte Carlo code stokes that incorporates both line and continuum processes, including multiple scatterings and absorption. We created a new xspec model, called xsstokes, which in this version enables efficient X-ray polarimetric fitting of the torus parameters, observer’s inclination and primary emission properties, interpolating for arbitrary state of primary polarization. Comparison of the results to a Monte Carlo simulation allowing partial transparency shows that the no-transparency condition may induce different polarization by tens of per cent. Allowing partial transparency leads to lower/higher polarization fraction, if the resulting polarization orientation is perpendicular/parallel to the rotation axis. We provide another version of xsstokes that is suitable for approximating nearly neutral reflection from a distant optically thick disc of small geometrical thickness. It assumes local illumination averaged for a selected range of incident angles, representing a toy model of a diffuse corona of various physical extent. Assessing both xsstokes variants, we conclude that the resulting polarization can be tens of per cent and perpendicularly/parallelly oriented towards the rotation axis, if the reflecting medium is rather vertically/equatorially distributed with respect to a compact central source.
microRNA-7-5p (miR-7-5p) is a tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor (EGFR) ...signaling pathway. While melanoma is not typically EGFR-driven, expression of miR-7-5p is reduced in metastatic tumors compared to primary melanoma. Here, we investigated the biological and clinical significance of miR-7-5p in melanoma. We found that augmenting miR-7-5p expression in vitro markedly reduced tumor cell viability, colony formation and induced cell cycle arrest. Furthermore, ectopic expression of miR-7-5p reduced migration and invasion of melanoma cells in vitro and reduced metastasis in vivo. We used cDNA microarray analysis to identify a subset of putative miR-7-5p target genes associated with melanoma and metastasis. Of these, we confirmed nuclear factor kappa B (NF-κB) subunit RelA, as a novel direct target of miR-7-5p in melanoma cells, such that miR-7-5p suppresses NF-κB activity to decrease expression of canonical NF-κB target genes, including IL-1β, IL-6 and IL-8. Importantly, the effects of miR-7-5p on melanoma cell growth, cell cycle, migration and invasion were recapitulated by RelA knockdown. Finally, analysis of gene array datasets from multiple melanoma patient cohorts revealed an association between elevated RelA expression and poor survival, further emphasizing the clinical significance of RelA and its downstream signaling effectors. Taken together, our data show that miR-7-5p is a potent inhibitor of melanoma growth and metastasis, in part through its inactivation of RelA/NF-κB signaling. Furthermore, miR-7-5p replacement therapy could have a role in the treatment of this disease.
We report on the detection of X-ray polarisation in the black-hole X-ray binary Swift J1727.8−1613 during its dim hard spectral state by the Imaging X-ray Polarimetry Explorer (IXPE). This is the ...first detection of X-ray polarisation at the transition from the soft to the hard state in an X-ray binary. We find an averaged 2–8 keV polarisation degree of (3.3 ± 0.4)% and a corresponding polarisation angle of 3° ±4°, which matches the polarisation detected during the rising stage of the outburst, in September–October 2023, within 1 σ uncertainty. The observational campaign complements previous studies of this source and enables comparison of the X-ray polarisation properties of a single transient across the X-ray hardness-intensity diagram. The complete recovery of the X-ray polarisation properties, including the energy dependence, came after a dramatic drop in the X-ray polarisation during the soft state. The new IXPE observations in the dim hard state at the reverse transition indicate that the accretion properties, including the geometry of the corona, appear to be strikingly similar to the bright hard state during the outburst rise despite the X-ray luminosities differing by two orders of magnitude.
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