A highly granular electromagnetic calorimeter with scintillator strip readout is being developed for future lepton collider experiments. A prototype of 21.5 \(X_0\) depth and \(180 \times 180 ...\)mm\(^2\) transverse dimensions was constructed, consisting of 2160 individually read out \(10 \times 45 \times 3\) mm\(^3\) scintillator strips. This prototype was tested using electrons of 2--32 GeV at the Fermilab Test Beam Facility in 2009. Deviations from linear energy response were less than 1.1\%, and the intrinsic energy resolution was determined to be \((12.5 \pm 0.1 (\mathrm{stat.}) \pm0.4 (\mathrm{syst.}))\%/\sqrt{E\mathrm{GeV}}\oplus (1.2 \pm 0.1(\mathrm{stat.})^{+0.6}_{-0.7}(\mathrm{syst.}))\%\), where the uncertainties correspond to statistical and systematic sources, respectively.
The electronics producing a few nanoseconds long LED pulses tuneable in the amplitude and the optical system distributing the LED light to scintillators by a single optical fibre are described. The ...properties of the LED pulses are controlled by a computer connected via a CANbus to the controller on the board. We produced a prototype with 6 LED pulse drivers placed on a 4-layer PCB with dimension 250 x 147 mm2. The pulse width is constant and 3 ns long. Its amplitude can be tuned from zero to 1.2 A. The pulse frequency can be set in the range up to 100 kHz. The LED light is distributed by a 1 mm diameter optical fibre. On the length of 2 m the fibre has every 30 mm a notch which flashes light with homogeneity of \pm20%. The system is foreseen for calibration of silicon photomultipliers embedded in scintillation tiles.
We present a study of showers initiated by electrons, pions, kaons, and protons with momenta from 15 GeV to 150 GeV in the highly granular CALICE scintillator-tungsten analogue hadronic calorimeter. ...The data were recorded at the CERN Super Proton Synchrotron in 2011. The analysis includes measurements of the calorimeter response to each particle type as well as measurements of the energy resolution and studies of the longitudinal and radial shower development for selected particles. The results are compared to Geant4 simulations (version 9.6.p02). In the study of the energy resolution we include previously published data with beam momenta from 1 GeV to 10 GeV recorded at the CERN Proton Synchrotron in 2010.
Showers produced by positive hadrons in the highly granular CALICE scintillator-steel analogue hadron calorimeter were studied. The experimental data were collected at CERN and FNAL for single ...particles with initial momenta from 10 to 80 GeV/c. The calorimeter response and resolution and spatial characteristics of shower development for proton- and pion-induced showers for test beam data and simulations using Geant4 version 9.6 are compared.
A detailed investigation of hadronic interactions is performed using -mesons with energies in the range 2–10 GeV incident on a high granularity silicon–tungsten electromagnetic calorimeter. The data ...were recorded at FNAL in 2008. The region in which the -mesons interact with the detector material and the produced secondary particles are characterised using a novel track-finding algorithm that reconstructs tracks within hadronic showers in a calorimeter in the absence of a magnetic field. The principle of carrying out detector monitoring and calibration using secondary tracks is also demonstrated.
A detailed investigation of hadronic interactions is performed using $\pi^-$-mesons with energies in the range 2--10 GeV incident on a high granularity silicon-tungsten electromagnetic calorimeter. ...The data were recorded at FNAL in 2008. The region in which the $\pi^-$-mesons interact with the detector material and the produced secondary particles are characterised using a novel track-finding algorithm that reconstructs tracks within hadronic showers in a calorimeter in the absence of a magnetic field. The principle of carrying out detector monitoring and calibration using secondary tracks is also demonstrated.
Calorimeters with a high granularity are a fundamental requirement of the Particle Flow paradigm. This paper focuses on the prototype of a hadron calorimeter with analog readout, consisting of ...thirty-eight scintillator layers alternating with steel absorber planes. The scintillator plates are finely segmented into tiles individually read out via Silicon Photomultipliers. The presented results are based on data collected with pion beams in the energy range from 8GeV to 100GeV. The fine segmentation of the sensitive layers and the high sampling frequency allow for an excellent reconstruction of the spatial development of hadronic showers. A comparison between data and Monte Carlo simulations is presented, concerning both the longitudinal and lateral development of hadronic showers and the global response of the calorimeter. The performance of several GEANT4 physics lists with respect to these observables is evaluated.
ALSUntangled #66: antimycobacterial antibiotics Pierce, Ellen S.; Barkhaus, Paul; Beauchamp, Morgan ...
Amyotrophic lateral sclerosis and frontotemporal degeneration,
07/2023, Letnik:
24, Številka:
5-6
Journal Article
Recenzirano
Odprti dostop
Several infections have been associated with motor neuron diseases resembling ALS, including species of viruses, bacteria, and parasites. Mycobacterium avium subspecies paratuberculosis (MAP), most ...known for its probable etiologic association with Crohn's disease, has been suggested as another possible infectious cause of motor neuron disease. Two published case reports describe the successful treatment of ALS-like symptoms with antimycobacterial antibiotics. Both cases had atypical features. Based on these, we believe it would be reasonable to begin performing chest imaging in PALS who have features of their history or exam that are atypical for ALS such as pain, fevers, or eye movement abnormalities. If the chest imaging is abnormal, more specific testing for mycobacteria may be indicated. Until there is more clear evidence of an association between mycobacteria and ALS, we cannot endorse the widespread use of potentially toxic antimycobacterial antibiotics for PALS.
Kutatasi eredmenyeink, lehetosegeink Kadar, I; Polak, I
Az Erdeszeti es Faipari Egyetem tudomanyos kozlemenyei = Scientific publications of the University of Forestry and Timber Industry,
1981, Letnik:
1
Publication
