The prototyping/early construction phase of the BAIKAL-GVD project Avrorin, A.D.; Avrorin, A.V.; Aynutdinov, V.M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2014, Letnik:
742
Journal Article
Recenzirano
Odprti dostop
The prototyping phase of the BAIKAL-GVD project has been started in April 2011 with the deployment of a three string engineering array which comprises all basic elements and systems of the Gigaton ...Volume Detector (GVD) in Lake Baikal. In April 2012 the version of engineering array which comprises the first full-scale string of the GVD demonstration cluster had been deployed and operated during 2012. The first stage of the GVD-cluster which consists of three strings was deployed in April 2013. We review the prototyping phase of the BAIKAL-GVD project and describe the configuration and design of the 2013 engineering array.
Current status of the BAIKAL-GVD project Avrorin, A.V.; Aynutdinov, V.M.; Belolaptikov, I.A. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
10/2013, Letnik:
725
Journal Article
Recenzirano
We present a status of the Baikal-GVD Project. The objective of this project is a construction of a km3-scale neutrino telescope in the Lake Baikal. As an important milestone, the first GVD ...engineering array has been deployed and ran in April, 2011. Application of a completely new technology gave us an opportunity to study all the basic elements of the future full detector and to finalize the GVD technical design. We discuss the configuration and the design of the engineering array as well as data performance with the preliminary results.
We review the current status of large area photodetectors for astroparticle physics Cherenkov experiments. Some advantages and disadvantages of classical PMTs and hybrid phototubes are discussed.
The Prototyping phase of the BAIKAL-GVD project has been started in April 2011 with the deployment of first autonomous engineering array which comprises all basic elements and systems of the Gigaton ...Volume Detector (GVD) in Lake Baikal. The prototyping phase will be concluded with deployment of the GVD demonstration cluster “DUBNA” in 2015, which will comprise 192 light sensors arranged at 8 strings. The first stage of the GVD demonstration cluster which consists of three strings was deployed in April 2013 and successfully operated up to February 2014. We review the prototyping phase of the BAIKAL-GVD project and describe the configuration and design of the 2013 engineering array.
Status of the Baikal-GVD project Avrorin, A.V.; Aynutdinov, V.M.; Bannasch, R. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
11/2012, Letnik:
692
Journal Article
Recenzirano
Odprti dostop
The construction of a km3-scale neutrino telescope – the Gigaton Volume Detector (GVD) in Lake Baikal – is the central goal of the Baikal collaboration. During the R&D phase of the GVD project in ...2008–2010 years the basic elements of GVD – new optical modules, FADC readout units, underwater communications and trigger systems – have been developed, produced and tested in situ by long-term operating prototype strings in Lake Baikal. The prototyping phase of the GVD project has been started in April 2011 with the installation of a three string array (prototype cluster) which comprises all basic elements and systems of the GVD-telescope in Lake Baikal. We describe configuration and technical design of the GVD, present selected results obtained during 2008–2010 with prototype strings, and describe configuration and design of the 2011 prototype cluster.
Plasma oxylipin profiles reflect Parkinson's disease stage Chistyakov, Dmitry V.; Azbukina, Nadezhda V.; Lopachev, Alexander V. ...
Prostaglandins & other lipid mediators,
April 2024, 2024-Apr, 2024-04-00, 20240401, Letnik:
171
Journal Article
Recenzirano
Derivatives of polyunsaturated fatty acids (PUFAs), also known as oxylipins, are key participants in regulating inflammation. Neuroinflammation is involved in many neurodegenerative diseases, ...including Parkinson's disease. The development of ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) facilitated the study of oxylipins on a system level, i.e., the analysis of oxylipin profiles. We analyzed oxylipin profiles in the blood plasma of 36 healthy volunteers (HC) and 73 patients with Parkinson’s disease (PD), divided into early (L\M, 29 patients) or advanced (H, 44 patients) stages based on the Hoehn and Yahr scale. Among the 40 oxylipins detected, we observed a decrease in the concentration of arachidonic acid (AA) and AA derivatives, including anandamide (AEA) and Leukotriene E4 (LTE4), and an increase in the concentration of hydroxyeicosatetraenoic acids 19-HETE and 12-HETE (PD vs HC). Correlation analysis of gender, age of PD onset, and disease stages revealed 20 compounds the concentration of which changed depending on disease stage. Comparison of the acquired oxylipin profiles to openly available PD patient brain transcriptome datasets showed that plasma oxylipins do not appear to directly reflect changes in brain metabolism at different disease stages. However, both the L\M and H stages are characterized by their own oxylipin profiles – in patients with the H stage oxylipin synthesis is increased, while in patients with L\M stages oxylipin synthesis decreases compared to HC. This suggests that different therapeutic approaches may be more effective for patients at early versus late stages of PD.
•UPLC-MS/MS analysis of plasma oxylipins: 73 samples from patient with Parkinson's disease (PD) and 36 healthy volunteers (HC).•The concentration of plasma AA, AEA and LTE4 decreased while 19-HETE and 12-HETE increased in PD vs HC.•Plasma oxylipin profiles differ in patients with early and advanced Parkinson's disease.
Low background experiments need active muon veto detectors to shield them from cosmic muons. Plastic scintillator panels with WLS fiber and multi-pixel Geiger-mode avalanche photodiodes readout are ...widely used in such experiments due to their compactness and robustness. In this paper, results from the study of the basic MRS APD parameters, such as breakdown voltages, quenching resistors, internal gain and dark count rates are presented, as well as temperature dependencies of some of these parameters. In a small fraction of the MRS APDs, some strange dips in the I–V curves just preceding the breakdown voltage point have been observed.
Wilson’s disease (WD) is a rare autosomal recessive metabolic disorder resulting from mutations in the copper-transporting, P-type ATPase gene ATP7B gene, but influences of epigenetics, environment, ...age, and sex-related factors on the WD phenotype complicate diagnosis and clinical manifestations. Oxylipins, derivatives of omega-3, and omega-6 polyunsaturated fatty acids (PUFAs) are signaling mediators that are deeply involved in innate immunity responses; the regulation of inflammatory responses, including acute and chronic inflammation; and other disturbances related to any system diseases. Therefore, oxylipin profile tests are attractive for the diagnosis of WD. With UPLC-MS/MS lipidomics analysis, we detected 43 oxylipins in the plasma profiles of 39 patients with various clinical manifestations of WD compared with 16 healthy controls (HCs). Analyzing the similarity matrix of oxylipin profiles allowed us to cluster patients into three groups. Analysis of the data by VolcanoPlot and partial least square discriminant analysis (PLS-DA) showed that eight oxylipins and lipids stand for the variance between WD and HCs: eicosapentaenoic acid EPA, oleoylethanolamide OEA, octadecadienoic acids 9-HODE, 9-KODE, 12-hydroxyheptadecatrenoic acid 12-HHT, prostaglandins PGD2, PGE2, and 14,15-dihydroxyeicosatrienoic acids 14,15-DHET. The compounds indicate the involvement of oxidative stress damage, inflammatory processes, and peroxisome proliferator-activated receptor (PPAR) signaling pathways in this disease. The data reveal novel possible therapeutic targets and intervention strategies for treating WD.
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