An important class of active labor market policy has received little impact evaluation: immigration barriers intended to raise wages and employment by shrinking labor supply. Theories of endogenous ...technical advance raise the possibility of limited or even perverse impact. We study a natural policy experiment: the exclusion of almost half a million Mexican bracero farm workers from the United States to improve farm labor market conditions. With novel labor market data we measure state-level exposure to exclusion, and model the absent changes in technology or crop mix. We fail to reject zero labor market impact, inconsistent with this model.
In response to the recent migrant and refugee crisis, rich countries have redoubled policy efforts to deter future immigration from poor countries by addressing the "root causes" of these movements. ...We review existing evidence on the extent and effectiveness of such efforts. First, development aid disbursements do not generally follow "root causes" rhetoric. The sectoral distribution of aid to migrant-origin countries does not significantly differ from its distribution in other countries. Second, the evidence suggests that the capacity of development assistance to deter migration is small at best. Aid can only encourage economic growth, employment, and security to a limited degree. Beyond this, successful development in almost all formerly poor countries has produced an increase in emigration. Third, this evidence implies that donors could achieve greater impact by leveraging development aid not to deter migration but to shape it for mutual benefit.
This paper proposes a novel pre-processing technique to improve record linkage for historical Chinese populations. Current matching approaches are relatively ineffective due to Chinese-specific ...naming conventions and enumeration errors. This paper develops a three-step process that both triples the match rate over baseline and improves match accuracy. The procedures developed in this paper can be applied in part or in full to other sources of historical data, and/or modified for use with other character-based languages such as Japanese. More broadly, this approach suggests the promise of language-specific linkage procedures to boost match rates for ethnic minority groups.
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new ...treatment strategies for this hard-to-treat patient population, yet studies using high-throughput and accurate models to define the functions of driver genes in TNBC to date have been limited. Here, we employed unbiased functional genomics screening of the 200 most frequently mutated genes in breast cancer, using spheroid cultures to model
-like conditions, and identified the histone acetyltransferase CREBBP as a novel tumor suppressor in TNBC. CREBBP protein expression in patient tumor samples was absent in 8% of TNBCs and at a high frequency in other tumors, including squamous lung cancer, where CREBBP-inactivating mutations are common. In TNBC, CREBBP alterations were associated with higher genomic heterogeneity and poorer patient survival and resulted in upregulation and dependency on a FOXM1 proliferative program. Targeting FOXM1-driven proliferation indirectly with clinical CDK4/6 inhibitors (CDK4/6i) selectively impaired growth in spheroids, cell line xenografts, and patient-derived models from multiple tumor types with CREBBP mutations or loss of protein expression. In conclusion, we have identified CREBBP as a novel driver in aggressive TNBC and identified an associated genetic vulnerability in tumor cells with alterations in CREBBP and provide a preclinical rationale for assessing CREBBP alterations as a biomarker of CDK4/6i response in a new patient population. SIGNIFICANCE: This study demonstrates that CREBBP genomic alterations drive aggressive TNBC, lung cancer, and lymphomas and may be selectively treated with clinical CDK4/6 inhibitors.
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