Hepatic polypeptide nutrient solution (HP) is a mixture of hepatoprotective peptides derived from fresh porcine liver with various effects. However, the role and mechanisms of HP in nonalcoholic ...fatty liver disease (NAFLD) are still not well understood. We investigated the effects of HP NAFLD rats induced by high-cholesterol diet (HCD) and its underlying mechanisms. Rats were provided with HCD for 4 weeks and then received HP or metformin after 2 weeks of HCD feeding. The study found that HP reduced cholesterol and triglyceride levels in rats with NAFLD (all
< .05). Histopathological examination also showed that HP improved the liver lesions induced by the HCD diet. Furthermore, the oxidative stress and inflammatory responses of NAFLD rats treated with HP were also improved. In addition, it was discovered that HP triggered the activation of AMPK and decreased the expression of SREBP-1c and FAS while enhancing the expression of PPAR α and CPT-1 in liver. These findings indicated that HP might have therapeutic potential for NAFLD, possibly via activating AMPK signaling pathway.
Biodegradable self-healing hydrogels with antibacterial property attracted growing attentions in biomedication as wound dressings since they can prevent bacterial infection and promote wound healing ...process. In this research, a biodegradable self-healing hydrogel with ROS scavenging performance and enhanced tissue adhesion was fabricated from dopamine grafted oxidized pectin (OPD) and naphthoate hydrazide terminated PEO (PEO NH). At the same time, Fe3+ ions were incorporated to endow the hydrogel with near-infrared (NIR) triggered photothermal property to obtain antibacterial activity. The composite hydrogel showed good hemostasis performance based on mussel inspired tissue adhesion with biocompatibility well preserved. As expected, the composition of FeCl3 improved conductivity and endowed photothermal property to the hydrogel. The in vivo wound repairing experiment revealed the 808 nm NIR light triggered photothermal behavior of the hydrogel reduced the inflammation response and promoted wound repairing rate. As a result, this composite FeCl3/hydrogel shows great potential to be an excellent wound dressing for the treatment of infection prong wounds with NIR triggers.
Rare genetic variants are abundant in genomes but less tractable in genome-wide association study. Here we exploit a strategy of rare variation mapping to discover a gene essential for tendril ...development in cucumber （Cucumis sativus L.）. In a collection of 〉3000 lines, we discovered a unique tendril-less line that forms branches instead of tendrils and, therefore, loses its climbing ability. We hypothesized that this unusual phenotype was caused by a rare variation and subsequently identified the causative single nucleotide poly- morphism. The affected gene TEN encodes a TCP transcription factor conserved within the cucurbits and is expressed specifically in tendrils, representing a new organ identity gene. The variation occurs within a pro- tein motif unique to the cucurbits and impairs its function as a transcriptional activator. Analyses of transcrip- tomes from near-isogenic lines identified downstream genes required for the tendril＇s capability to sense and climb a support. This study provides an example to explore rare functional variants in plant genomes.
Display omitted
Recently, Fe-based metal–organic frameworks (MOFs) have attracted increasing attention and been widely used. To date, however, it is unknown whether they can be employed to degrade ...tetracycline, one of the most widely used antibiotics. This work therefore aims to provide such support by comparing the performance of three Fe-based MOFs (namely, Fe-MIL-101, Fe-MIL-100, and Fe-MIL-53) in removing tetracycline. Experimental results showed that Fe-MIL-101 exhibited the best performance in tetracycline removal, with 96.6% of tetracycline being removed (initial tetracycline concentration at 50 mg/L) while Fe-MIL-100 and Fe-MIL-53 removed 57.4% and 40.6% under the same conditions. Additionally, the effects of adding dosage, adsorption time, and initial concentration of tetracycline on degradation efficiency were examined. It was found that the adsorption and photocatalytic degradation effect was better with the increase of time, the optimum dosage of Fe-MIL-101 was 0.5 g/L and the removal efficiency decreased with the increasing of initial tetracycline concentrations. Moreover, the trapping experiments and ESR tests indicated that O2−, OH and h+ were the main active species in photocatalytic degradation process of tetracycline. Due to its high removal efficiency and simple synthesis, it could be used as a potential catalyst for degradation of tetracycline and other antibiotics.
Metal organic frameworks (MOFs), as an original kind of organic–inorganic porous material, are constructed with metal centers and organic linkers via a coordination complexation reaction. Among ...uncountable MOF materials, iron‐containing metal organic frameworks (Fe‐MOFs) have excellent potential in practical applications owing to their many fascinating properties, such as diverse structure types, low toxicity, preferable stability, and tailored functionality. Here, recent research progresses of Fe‐MOFs in attractive features, synthesis, and multifunctional applications are described. Fe‐MOFs with porosity and tailored functionality are discussed according to the design of building blocks. Four types of synthetic methods including solvothermal, hydrothermal, microwave, and dry gel conversion synthesis are illustrated. Finally, the applications of Fe‐MOFs in Li‐ion batteries, sensors, gas storage, separation in gas and liquid phases, and catalysis are elucidated, focusing on the mechanism. The aim is to provide prospects for extending Fe‐MOFs in more practical applications.
Iron‐containing metal organic frameworks (Fe‐MOFs) have attracted intensive attention due to their unique topological structure and exploitable properties. Owing to the functional applications in electrochemical devices and its adsorbent and photo‐electrocatalyst properties, Fe‐MOFs have become an emerging hot topic for high‐performance energy conversion devices, gas/liquid separation, and advanced catalysis.
•Graphene oxide was synthesized by a modified Hummers’ method.•The Zn(II) removal by adsorption was directly dependent on the pH.•The Zn(II) adsorption process can be explained by pseudo-second-order ...kinetic model.•Adsorption of Zn(II) fitted well with Langmuir model at different temperatures.•The maximum adsorption capacity of Zn(II) on graphene oxide was up to 245.70mg/g.
In this study, graphene oxide (GO) was synthesized via modified Hummers’ method, and characterized by scanning electron microscopy (SEM), atomic force microscope (AFM), X-ray diffraction (XRD), and Fourier transform infrared spectrum (FT-IR), X-ray photoelectron spectroscopy (XPS). The adsorption of Zn(II) on GO as a function of pH, adsorbent dosage, foreign ions, contact time, and temperature was investigated using batch technique. Results showed that the suitable pH for Zn(II) removal was about 7.0, and the optimal dosage was 2mg. The adsorption of Zn(II) onto GO increased sharply within 20min and obtained equilibrium gradually. Meanwhile, foreign ion and temperature also affected the adsorption performance of GO. The adsorption process was found to be well described by the pseudo-second-order rate model. Equilibrium studies indicated that the data of Zn(II) adsorption followed the Langmuir model. The maximum adsorption capacity for Zn(II) was up to 246mg/g with a Langmuir adsorption equilibrium constant of 5.7L/g at 20°C. The thermodynamic parameters calculated from temperature-dependent sorption isotherms suggested that Zn(II) sorption on GO was an exothermic and spontaneous process in nature. The possibility of Zn(II) recovery was investigated and the result revealed that the maximum Zn(II) recovery yield was achieved with hydrochloric acid.
Display omitted
•Structure and features of Ti-MOF-based photocatalytic systems are summarized.•Three types synthetic strategy of Ti-MOFs are introduced.•Ti-MOFs, composites and derived porous ...materials for photocatalysis are discussed.•Challenges and future directions of Ti-MOFs for photocatalysis are provided.
Photocatalysis driven by functionalized metal–organic frameworks (MOFs) is a promising direction for the development of renewable energy conversion and environmental pollution rehabilitation by direct utilization of solar energy. Among various MOFs, titanium (Ti)-based MOFs (Ti-MOFs) are an appealing set of MOFs for practical applications due to their relation to the commonly used TiO2, their unique structural features, relatively low toxicity and excellent optical properties. This review summarizes recent research progress on Ti-MOFs and their composites as well as the porous materials derived from them in photocatalytic applications. The selection of appropriate central metal ions and organic ligands has significant influence on the fabrication of Ti-MOFs with good photocatalytic properties. To regulate the photoresponse and photocatalytic activity, controllable integration of a Ti-MOF system with photo-sensitive materials, resulting in the formation of new multifunctional hybrids, is required. In addition, the calcination of Ti-MOF precursors provides a useful method for preparing promising photocatalysts with novel structures, close contact interfaces, and easy regulation. Finally, the opportunities and challenges for future exploration of Ti-MOFs are discussed from a critical perspective along with those of their composites and derived porous materials.
In this study, an efficient metal to ligand charge transfer (MLCT) was successfully implanted into the Cu-CNF via the bonds of coordinated Cu(I) with organic N and few inorganic O atoms, avoiding the ...long-distance charge transport via HOMO to LUMO transition and accelerating the visible light absorption and exciton dissociation.
Display omitted
•Cu-CNF with the efficient MLCTs exhibits enhanced photocatalytic efficiency.•Visible light absorption and exciton dissociation are intensified in Cu-CNF.•The C-Cl and C-N-C moiety of CTC-HCl are initially attacked in degradation process.•NO2-N and NH3-N restrain the removal efficiency of CTC-HCl in the swine wastewater.•Organic matter in natural water leads to the decreased CTC-HCl removal efficiency.
The overuse of refractory antibiotics in animal husbandry has caused serious aqueous environment pollution. Polymeric carbon nitride (CN) based photocatalysis, a promising method to address antibiotic pollution issues, has encountered with restricted efficiency because of the sluggish charge transfer and unexploited water matrices influence. In this study, an efficient metal to ligand charge transfer (MLCT) was successfully implanted into the Cu(I) coordinately polymeric carbon nitride framework (Cu-CNF) via the bonds of coordinated Cu(I) with organic N and few inorganic O atoms. The Cu-CNF photocatalysts were endowed with high-efficient chlortetracycline hydrochloride (CTC-HCl) removal in deionized water. To insure the feasibility of the Cu-CNF in antibiotics removal from different water matrices, a systematical exploration covering the reaction kinetics, the physicochemical stability, and the influence of specific water matrices on CTC-HCl removal was carried out by various ways. Results showed that the photo-induced MLCT route with shorter transfer distance was able to broaden light absorption of CN in the whole visible region, contributing to more available excitons and accelerating separation of the photoexcited electron-hole pairs. The boosted active oxidative species (h+, O2− and ∙OH) in porous Cu-CNF were found to promote the dechlorination and benzene ring cleavage process to favor the final mineralization of CTC-HCl molecules. Under the synergistic influence of water constituents, the removal efficiency of CTC-HCl was highest in river water (68.2%), followed by tap water (45.7%), and swine wastewater (33.1%). It was found that the existence of the high concentration NOx-N and NH3-N in the swine wastewater were responsible for the collapsed removal efficiency of CTC-HCl. Natural organic matter in river water and tap water was the main factor for the decreased CTC-HCl removal efficiency.
The treatment of bacterial infection is one of the most challenging tasks in the biomedical field. Antibiotics were developed over 70 years and are regarded as the most efficient type of drug to ...treat bacterial infection. However, there is a concern that the overuse of antibiotics can lead to a growing number of multidrug-resistant bacteria. The development of antibiotic delivery systems to improve the biodistribution and bioavailability of antibiotics is a practical strategy for reducing the generation of antibiotic resistance and increasing the lifespan of newly developed antibiotics. Here we present an antibiotic delivery system (Van⊂SGNPs@RBC) based on core–shell supramolecular gelatin nanoparticles (SGNPs) for adaptive and “on-demand” antibiotic delivery. The core composed of cross-linked SGNPs allows for bacterial infection–microenvironment responsive release of antibiotics. The shell coated with uniform red blood cell membranes executes the function of disguise for reducing the clearance by the immune system during the antibiotic delivery, as well as absorbs the bacterial exotoxin to relieve symptoms caused by bacterial infection. This approach demonstrates an innovative and biomimetic antibiotic delivery system for the treatment of bacterial infection with a minimum dose of antibiotics.
Display omitted
Novel metal-organic framework/stannous sulfide (MIL-53(Fe)/SnS) nanocomposite photocatalysts were successfully synthesized by a one-step deposition process. The structure, composition ...and optical properties of the MIL-53(Fe)/SnS composite were systematically characterized by the X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, Fourier transform-infrared spectroscopy, UV–vis diffuse reflection spectroscopy and photoluminescence analysis. The photocatalytic performance of MIL-53(Fe)/SnS composite has been evaluated in the reduction of chromium (VI) under visible-light irradiation. Compared with pure MIL-53(Fe) and SnS, the MIL-53(Fe)/SnS composite exhibited enhanced photoreduction capability of chromium (VI) due to the strengthened absorption in the visible region, higher electron-hole separation rate and larger specific area. The MIL-53(Fe)/SnS composite with MIL-53(Fe) adding of 15 mg displayed optimal chromium (VI) reduction rate of 0.01878 min−1, which was about 7.5 and 5.2 times than pure MIL-53(Fe) and SnS, respectively. The active species superoxide radical (O2–), electron(e−) and hole(h+) are essential toward chromium (VI) reduction. Lastly, a possible photocatalytic mechanism is proposed.
PDF
