There has been an increase in the incidence of breast cancer cases in the last decade, and despite the treatment increasing the chances of survival, it reduces the quality of life. In this context, ...diets could decrease the adverse effects of treatment and improve quality of life.
A form with the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire, which contains specific scores for physical, cognitive, emotional, symptomatic, and functional performance, was made available in a Facebook support group. Afterward, the data were analyzed using linear regression and a t-test of independent samples using Jamovi version 2.3.24 (retrieved from https://www.jamovi.org).
There was a low number of participants who followed the ketogenic diet or intermittent fasting. In general, adherence to the diets was good. In the t-test, diets showed improvement in physical performance. Linear regression correlated treatment with chemotherapy, metastases, and bad diet adherence with worse symptomatic scores.
There is evidence that diets can improve the symptoms of these patients; however, there is no consensus about which diet produces the best effect, requiring further studies on this subject.
Abstract
Textile effluents are complex, making it difficult to choose an effective treatment. The textile effluent toxicity in Lactuca sativa after pulsed current (PC) electrocoagulation (EC) was ...evaluated in this study. The EC was performed using 304 stainless steel electrodes in batch mode. Parameters monitored included pH, temperature, color, and turbidity. Additionally, the process residue was subjected to energy-dispersive X-ray fluorescence (XFR) to determine the elements present. The process achieved proportional color and turbidity removal ranging from 97 to 99% and from 74 to 85%, respectively. Chemical oxygen demand (COD) and total nitrogen removal were 81 and 49%, respectively, in a 50 min time-lapse. The process generated approximately 1.7 kg of solid residue/m3 treated effluent. The XFR results revealed the presence, mainly, of Fe, Cr, and Ni ions in the residue, as well as chlorine. The germination index (GI) and relative growth values showed that EC reduced effluent toxicity slightly, indicating the need for complementary treatment.
The use of the pulsed current can be an alternative to decrease the electrode polarization, as well as achieving lower energy consumption. This study investigated the electrocoagulation through ...pulsed current for the removal of natural organic matter from water. The experiments were carried out using Box-Behnken factorial design with the response surface methodology for the design of experiments, modeling and interpreting of the results. The electrocoagulation cell consisted of an acrylic reactor with 4 L capacity with four electrodes of aluminum, in parallel connection mode. The experimental independent variables studied were: current density (5.5 to 44.5 A m
), electrodes spacing (2 to 7.6 mm), stirring rate (200 to 1,000 rpm), frequency (500 to 5,000 Hz), humic acid concentration (5 to 20 mg L
) and NaCl (100 to 300 mg L
) as supporting electrolyte, evaluating the residual apparent color (RAC) and electric energy consumption (EEC). The pH of the solution increased during the experiments, reaching basic values. The response surface regression procedure was employed to fit the second-order polynomial, and the model fitted well to the obtained values, reaching R
0.9995 (RAC) and R
0.9989 (EEC). The lowest RAC was 11.8 Hazen units (96.2% color removal), where the EEC was 0.393 kWh m
.
RESUMO A remoção de poluentes de efluentes industriais de forma efetiva e economicamente viável ainda é um desafio. Dessa forma, o presente trabalho propôs investigar a tecnologia de eletrocoagulação ...(EC) para o tratamento de efluente têxtil utilizando corrente contínua pulsada (CCP). A metodologia de superfície de resposta Box-Behnken foi utilizada para analisar e otimizar as condições operacionais, visando à máxima remoção de demanda química de oxigênio (DQO). Os experimentos foram realizados com um volume reacional de 2,6 L, em modo batelada. Diante dos resultados obtidos, a configuração ótima considerada foi: velocidade de agitação = 200 rpm, frequência dos pulsos = 1.000 Hz e espaçamento entre os eletrodos = 1 mm, em 50 minutos de EC. Nessas condições foi obtida uma remoção de DQO de 81,23% (valor remanescente de 152 mg O2.L-1). Em adição, verificou-se que o processo de EC também é eficaz para a redução de cor, turbidez, sólidos suspensos totais, sulfato e sulfeto. A concentração de íons cloreto não foi alterada durante a EC, apresentando-se como um aspecto favorável para a reutilização do efluente tratado no próprio processo produtivo têxtil, o qual demanda uma elevada concentração de NaCl.
RESUMO A remoção de poluentes de efluentes industriais de forma efetiva e economicamente viável ainda é um desafio. Dessa forma, o presente trabalho propôs investigar a tecnologia de eletrocoagulação ...(EC) para o tratamento de efluente têxtil utilizando corrente contínua pulsada (CCP). A metodologia de superfície de resposta Box-Behnken foi utilizada para analisar e otimizar as condições operacionais, visando à máxima remoção de demanda química de oxigênio (DQO). Os experimentos foram realizados com um volume reacional de 2,6 L, em modo batelada. Diante dos resultados obtidos, a configuração ótima considerada foi: velocidade de agitação = 200 rpm, frequência dos pulsos = 1.000 Hz e espaçamento entre os eletrodos = 1 mm, em 50 minutos de EC. Nessas condições foi obtida uma remoção de DQO de 81,23% (valor remanescente de 152 mg O2.L-1). Em adição, verificou-se que o processo de EC também é eficaz para a redução de cor, turbidez, sólidos suspensos totais, sulfato e sulfeto. A concentração de íons cloreto não foi alterada durante a EC, apresentando-se como um aspecto favorável para a reutilização do efluente tratado no próprio processo produtivo têxtil, o qual demanda uma elevada concentração de NaCl.
ABSTRACT The effective and economically viable removal of industrial wastewater pollutants is still a challenge. Thus, this study proposed to investigate the electrocoagulation technology (EC) for the treatment of textile effluent using pulsed direct current (CCP). The methodology of Box-Behnken response surface was used to analyze and optimize the operating conditions, aimed at maximum chemical oxygen demand (COD) removal. The experiments were performed with a reaction volume of 2.6 L in batch mode. Based on these results, the optimal configuration was: agitation speed = 200 rpm, frequency of pulses = 1,000 Hz and spacing between electrodes = 1 mm, in 50 minutes of EC. Under these conditions it was obtained a COD removal of 81.23% (remainder value of 152 mg O2.L-1). In addition, it was found that the EC process is also effective for reduction of color, turbidity, total suspended solids, sulfate and sulfide. The concentration of chloride ions was not modified during the EC, presenting itself as a favorable aspect for the reuse of treated wastewater in the textile production process itself, which demands a high concentration of NaCl.
Malaria is an infectious disease widespread in underdeveloped tropical regions. The most severe form of infection is caused by Plasmodium falciparum, which can lead to development of cerebral malaria ...(CM) and is responsible for deaths and significant neurocognitive sequelae throughout life. In this context and considering the emergence and spread of drug-resistant P. falciparum isolates, the search for new antimalarial candidates becomes urgent. β-carbolines alkaloids are good candidates since a wide range of biological activity for these compounds has been reported. Herein, we designed 20 chemical entities and performed an in silico virtual screening against a pool of P. falciparum molecular targets, the Brazilian Malaria Molecular Targets (BRAMMT). Seven structures showed potential to interact with PfFNR, PfPK7, PfGrx1, and PfATP6, being synthesized and evaluated for in vitro antiplasmodial activity. Among them, compounds 3−6 and 10 inhibited the growth of the W2 strain at µM concentrations, with low cytotoxicity against the human cell line. In silico physicochemical and pharmacokinetic properties were found to be favorable for oral administration. The compound 10 provided the best results against CM, with important values of parasite growth inhibition on the 5th day post-infection for both curative (67.9%) and suppressive (82%) assays. Furthermore, this compound was able to elongate mice survival and protect them against the development of the experimental model of CM (>65%). Compound 10 also induced reduction of the NO level, possibly by interaction with iNOS. Therefore, this alkaloid showed promising activity for the treatment of malaria and was able to prevent the development of experimental cerebral malaria (ECM), probably by reducing NO synthesis.
In an increasingly dynamic environment, the speed of decision-making has become a differential, especially in a scenario that has many obstacles, such as the government. Interests from different ...spheres (municipal, state and federal) and different actors (political parties, benches, mobilization of popular groups), must be consolidated in the most assertive decision for society. Thus, methods that guarantee the decrease of subjectivity and increase the consolidation of different points of view are necessary. Thus, the objective of this study is to demonstrate the use of the analytical hierarchical process (AHP) via the Promethee II method to prioritize criteria for information technology demands within the Federal Public Ministry. This is an exploratory research with a qualitative-quantitative approach using multicriteria analysis. As a result of the study, the criteria Support, Strategic and Interested Parties were established, with the respective approximate weights of 65%, 28% and 7%. Eight alternatives were defined, where the most prominent was "Technical knowledge of the ICT team" with an approximate weight of 24.5%. The combination of criteria and alternatives applied during the research resulted, among the 12 selected, in the demand for Security as the highest priority and the demand for BI as the lowest priority, proving alignment with the institution's strategic objectives.
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