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zadetkov: 28
1.
  • Design of amidobenzimidazole STING receptor agonists with systemic activity
    Ramanjulu, Joshi M; Pesiridis, G Scott; Yang, Jingsong ... Nature (London), 12/2018, Letnik: 564, Številka: 7736
    Journal Article
    Recenzirano

    Stimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that propagates innate immune sensing of cytosolic pathogen-derived and self DNA . The development of compounds that ...
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2.
  • Human rhinovirus promotes S... Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
    Triantafilou, Martha; Ramanjulu, Joshi; Booty, Lee M ... Nature communications, 03/2022, Letnik: 13, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Human rhinovirus (HRV), like coronavirus (HCoV), are positive-strand RNA viruses that cause both upper and lower respiratory tract illness, with their replication facilitated by concentrating ...
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3.
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4.
  • Discovery of GSK8612, a Hig... Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor
    Thomson, Douglas W; Poeckel, Daniel; Zinn, Nico ... ACS medicinal chemistry letters, 05/2019, Letnik: 10, Številka: 5
    Journal Article
    Recenzirano
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    The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, ...
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5.
  • MALT1 Protease Activity Is ... MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses
    Yu, Jong W; Hoffman, Sandy; Beal, Allison M ... PloS one, 05/2015, Letnik: 10, Številka: 5
    Journal Article
    Recenzirano
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    CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this complex, MALT1 functions as both a ...
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6.
  • Overcoming the Pregnane X R... Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction
    Ramanjulu, Joshi M; Williams, Shawn P; Lakdawala, Ami S ... ACS medicinal chemistry letters, 09/2021, Letnik: 12, Številka: 9
    Journal Article
    Recenzirano
    Odprti dostop

    The pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, phase II enzymes, and ...
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7.
  • Titanium(IV) Isopropoxide M... Titanium(IV) Isopropoxide Mediated Synthesis of Pyrimidin-4-ones
    Ramanjulu, Joshi M; DeMartino, Michael P; Lan, Yunfeng ... Organic letters, 05/2010, Letnik: 12, Številka: 10
    Journal Article
    Recenzirano

    A novel, one-step method for the synthesis of tri- and tetrasubstituted pyrimidin-4-ones is reported. This method involves a titanium(IV)-mediated cyclization involving two sequential condensations ...
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9.
  • Total Synthesis of Vancomyc... Total Synthesis of Vancomycin Aglycon-Part 1: Synthesis of Amino Acids 4-7 and Construction of the AB-COD Ring Skeleton
    Nicolaou, K. C.; Natarajan, Swaminathan; Li, Hui ... Angewandte Chemie (International ed.), October 16, 1998, Letnik: 37, Številka: 19
    Journal Article
    Recenzirano

    A triazene‐based synthetic strategy for the construction of the complex biaryl ethers and a Suzuki coupling reaction were the key steps in the synthesis of precursor 1 of the aglycon of vancomycin, ...
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10.
  • Total Synthesis of Vancomyc... Total Synthesis of Vancomycin Aglycon-Part 3: Final Stages
    Nicolaou, K. C.; Takayanagi, Masaru; Jain, Nareshkumar F. ... Angewandte Chemie (International ed.), October 16, 1998, Letnik: 37, Številka: 19
    Journal Article
    Recenzirano

    A triazene‐based synthetic strategy for the construction of the complex biaryl ethers and a Suzuki coupling reaction were the key steps in the synthesis of precursor 1 of the aglycon of vancomycin, ...
Celotno besedilo
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zadetkov: 28

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