The existence of quantum computers and Shor's algorithm poses an imminent threat to classical public-key cryptosystems. These cryptosystems are currently used for the exchange of keys between servers ...and clients over the Internet. The Internet of Things (IoT) is the next step in the evolution of the Internet, and it involves the connection of millions of low-powered and resource-constrained devices to the network. Because quantum computers are becoming more capable, the creation of a new cryptographic standard that cannot be compromised by them is indispensable. There are several current proposals of quantum-resistant or post-quantum algorithms that are being considered for future standards. Given that the IoT is increasing in popularity, and given its resource-constrained nature, it is worth adapting those new standards to IoT devices. In this work, we study some post-quantum cryptosystems that could be suitable for IoT devices, adapting them to work with current cryptography and communication software, and conduct a performance measurement on them, obtaining guidelines for selecting the best for different applications in resource-constrained hardware. Our results show that many of these algorithms can be efficiently executed in current IoT hardware, providing adequate protection from the attacks that quantum computers will eventually be capable of.
The present study shows the untargeted metabolite profiling and in vitro antibacterial, cytotoxic, and nitric oxide (NO) inhibitory activities of the methanolic leaves extract (MLE) and methanolic ...stem extract (MSE) of Erythroxylum mexicanum, as well as the fractions from MSE. Using ultra‐high performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry (UHPLC‐QTOF‐MS/MS), a total of 70 metabolites were identified; mainly alkaloids in the MLE, while the MSE showed a high abundance of diterpenoids. The MSE fractions exhibited differential activity against Gram‐positive bacteria. Notably, the hexane fraction (HSF) against Streptococcus pyogenes ATCC 19615 (MIC=62.5 μg/mL) exhibited a bactericidal effect. The MSE fractions exhibited cytotoxicity against all cancer cell lines tested, with selectivity towards them compared to a noncancerous cell line. Particularly, the HSF and chloroform fraction (CSF) showed the highest cytotoxicity against prostate cancer (PC‐3) cells, with IC50 values of 19.9 and 18.1 μg/mL and selectivity indexes of 3.8 and 4.2, respectively. Both the HSF and ethyl acetate (EASF) fractions of the MSE inhibited NO production in RAW 264.7 macrophages, with NO production percentages of 50.0 % and 51.7 %, respectively, at a concentration of 30 μg/mL. These results indicated that E. mexicanum can be a source of antibacterial, cytotoxic, and anti‐inflammatory metabolites.
In the present study two extreme events that occurred in the East Coast of Northeast Brazil (ENEB) during 2022 and 2023 were evaluated. These events are becoming increasingly frequent in all regions ...of Brazil, associated with significant material and human losses, emphasizing the significance of a deeper comprehension of these events. ERA5 global reanalysis data, GOES-16 satellite imagery and pluviometric stations were used for the analysis. Model simulations were also conducted using the Model for Prediction Across Scales (MPAS) with variable resolution (60–3 km). Both events corresponded to Easterly Wave Disturbances (EWDs) that occurred under opposite large-scale conditions of the ENSO cycle, since extreme events are becoming increasingly frequent in all regions of Brazil and could be responsible for significant material and human losses. Thus, an emphasis was given to characterize the synoptic conditions. Both analyzed cases occurred along the ENEB, specifically over the Alagoas state. The trough axis penetrating the studied area was observed on both examined dates, with a very characteristic relative vorticity of this tropical disturbance. In general, moisture convergence resulted from the high flow of moisture prevailing over the region combined with upward movements caused by the trough present at low levels, which combined with local factors in the region such as topography, contributed to the increase in rainfall over the study area in both analyzed cases. The MPAS showed excellent spatial representation when compared to station data, highlighting intense precipitation over parts of Alagoas.
•The study highlights the impacts of the Easterly Waves under different configurations of ocean-atmosphere conditions.•Local factors such as topography could contribute to the increase in rainfall values in the study area.•This is the first study to use the MPAS model to simulate extreme precipitation events over the NEB.•MPAS simulations was able to simulate both the spatial distribution and the intensity of the observed precipitation.
At present, the synthesis of ammonia through the Haber–Bosch (HB) process accounts for 1.2% of the global carbon emissions, representing roughly one-fourth of the global fossil consumption from the ...chemical industry, which creates a pressing need for alternative low-carbon synthesis routes. Analyzing seven essential planetary boundaries (PBs) for the safe operation of our planet, we find that the standard HB process is unsustainable as it vastly transgresses the climate change PB. In order to identify more responsible strategies from this integrated perspective, we assess the absolute sustainability level of 34 alternative routes where hydrogen (H2) is supplied by steam methane reforming with carbon capture and storage, biomass gasification, or water electrolysis powered by various energy sources. We found that some of these scenarios could substantially reduce the global impact of fossil HB, yet alleviating the impact on climate change could critically exacerbate the impacts on other Earth-system processes. Furthermore, we identify that reducing the cost of electrolytic H2 is the main avenue toward the economic appeal of the most sustainable routes. Our work highlights the need to embrace global impacts beyond climate change in the assessment of decarbonization routes of fossil chemicals. This approach enabled us to identify more suitable alternatives and associated challenges toward environmental and economically attractive ammonia synthesis.
Abstract
Background
This study aimed to investigate overall and sex-specific excess all-cause mortality since the inception of the COVID-19 pandemic until August 2020 among 22 countries.
Methods
...Countries reported weekly or monthly all-cause mortality from January 2015 until the end of June or August 2020. Weekly or monthly COVID-19 deaths were reported for 2020. Excess mortality for 2020 was calculated by comparing weekly or monthly 2020 mortality (observed deaths) against a baseline mortality obtained from 2015–2019 data for the same week or month using two methods: (i) difference in observed mortality rates between 2020 and the 2015–2019 average and (ii) difference between observed and expected 2020 deaths.
Results
Brazil, France, Italy, Spain, Sweden, the UK (England, Wales, Northern Ireland and Scotland) and the USA demonstrated excess all-cause mortality, whereas Australia, Denmark and Georgia experienced a decrease in all-cause mortality. Israel, Ukraine and Ireland demonstrated sex-specific changes in all-cause mortality.
Conclusions
All-cause mortality up to August 2020 was higher than in previous years in some, but not all, participating countries. Geographical location and seasonality of each country, as well as the prompt application of high-stringency control measures, may explain the observed variability in mortality changes.
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included ...for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a functional variant located in carbamoyl phosphate synthetase-1 (CPS1) gene. Two preclinical models were employed to analyse CPS1 by immunohistochemistry, a choline deficient high-fat diet model (CDA-HFD) and a high fat diet LDLr knockout model (LDLr -/-). A significant downregulation in mRNA was observed in CPS1 and ornithine transcarbamylase (OTC1) in simple steatosis and NASH-fibrosis patients versus controls. Further, age, obesity (BMI > 30 kg/m
), diabetes mellitus and ALT were found to be risk factors whereas A-allele from CPS1 was a protective factor from liver fibrosis. CPS1 hepatic expression was diminished in parallel with the increase of fibrosis, and its levels reverted up to normality after changing diet in CDA-HFD mice. In conclusion, liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes. A-allele from a variant on CPS1 may protect from fibrosis development. CPS1 expression is restored in a preclinical model when the main trigger of the liver damage disappears.
The decision to allocate time and energy to find multiple sexual partners or raise children is a fundamental reproductive trade-off. The Strategic Pluralism Hypothesis argues that human reproductive ...strategies are facultatively calibrated towards either investing in mating or parenting (or a mixture), according to the expression of features dependent on the individual's condition. This study seeks to test predictions derived from this hypothesis in a sample of 242 young men (M ± SD = 22.12 ± 3.08) from Chile's 5th Region (33Ö¯ south latitude). Specifically, two predictions were considered that raise questions about the relationship between traits related to physical and psychological attractiveness (fluctuating facial asymmetry and self-perception of attractiveness) and competitive skills (baseline testosterone and self-perception of fighting ability) with short-term reproductive strategies. Our results indicate that psychological features related to the self-perception of physical attractiveness are related to short-term reproductive strategies. However, no evidence was found that fluctuating facial asymmetry, basal levels of testosterone and self-perception of fighting ability were related to short-term reproductive strategies. These results support the existing evidence of the importance of physical attractiveness in calibrating men's reproductive strategies but cast doubts about the role of fluctuating facial asymmetry. They also suggest that traits related to physical attractiveness, in comparison to competitive capabilities, play a more important role in calibrating men's short-term reproductive strategies.
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