Latest results on inclusive and differential top quark pair and
single top quark production cross sections are presented using
proton-proton collision data collected by the CMS experiment. The
...differential cross sections are measured as a function of various
kinematic observables of the top quarks and the jets and leptons of the
event final state. The results are confronted with precise theory
calculations and used to constrain Standard Model parameters.
Measurements are performed also with high
p_T
p
T
top quarks, i.e., in boosted regimes.
In this study, four surface water quality datasets of upper Damodar river basin (DRB) covering three seasons; pre-monsoon, monsoon, post-monsoon and annual, for years 2007–2010 were generated by ...analyzing 280 grab water samples. Each dataset consist of water quality constituents of 35 monitoring stations and sample of each station was evaluated by 17 critical parameters (total 4760 observations). Furthermore, each dataset was treated using six water quality indices (WQIs): four developed simplified indices (WQI
m
, WQI
min
, WQI
DO
, and WQI
pca
) and two existing extended indices (WQI
obj
and WQI
sub
), to assess spatiotemporal variations and suitability for human use and aquatic life. Results revealed that developed indices show on an average similar spatiotemporal variations as compared to WQI
obj
at a lower analytical cost at most of sampling sites comes under good to medium categories of water quality. Geographical information system (GIS) technique was also used for generation of temporal pollution potential maps of DRB. Consequently, this study also presents the necessity and usefulness of developed indices over extended indices especially for the developing countries, because the cost of monitoring and expenses associated with the implementation is less compared to extended methods and generated maps may also facilitate the decision-making processes under various scenarios considering spatial and temporal variability in DRB.
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•The functionalization of GOs has been done with hydrophilic polymer, PVP.•Loading and release of anticancer drugs GEF and QSR on GO-PVP were investigated.•The release profile of dual ...drug system is higher than single drug systems.•The cell killing activity was investigated in ovarian cancer cells.•Cocktailed drug system has more cytotoxicity against PA-1 ovarian cancer cells.
Graphene Oxide (GO) has been extensively studied in the field of biomedical sciences as one of the most promising biomaterials due to its exceptional physiochemical properties. Experts have long favored anticancer drug cocktails over single drugs, given that the former may provide a more balanced molecular basis for novel chemotherapeutic strategies. Here, we investigated a combinatorial anticancer drug treatment involving the well-proven anticancer drugs quercetin and gefitinib and compared it with gefitinib and quercetin loaded separately onto polyvinylpyrrolidone (PVP)-functionalized graphene oxide (GO-PVP). The loading and cancer cell cytotoxicity of the individual drug systems and their combined loading onto GO-PVP nanovehicles were investigated in PA-1 ovarian cancer cells and compared to their effects on IOSE-364 ovarian epithelial cells. In this report, the combined drug system loaded on the GO-PVP nanovehicle was found to be significantly more toxic than the individual drug loaded systems, as well as the free drugs, toward PA-1 cells compared to the toxicity toward IOSE-364 cells. The combined drug system loaded on the GO-PVP nanovehicle is likely to be more successful than individual drug therapy, given the stronger impact of the combinatorial approach and the efficiency of chemotherapeutic delivery.
This study presents a procedure to estimate more accurate direct surface runoff from large rainfall (>25.4 mm)-runoff events. Improved models (M5-M7) are derived by coupling two concepts: (i) initial ...abstraction as 2% of the total rainfall and (ii) runoff coefficient = degree of saturation. Performance of ten different models including the original SCS-CN method (M1), Mishra and Singh
2002
(M2), Mishra et al.
2006
(M3), Ajmal et al.
2016
(M4), improved models (M5-M7) and their simplified forms (M8-M10) is evaluated using large (7687) number of rainfall events derived from 98 watersheds of USDA-ARS to assess the accuracy of runoff estimation. Quantitatively, it is assessed using seven performance indices, viz., R
2
, NSE, PBIAS, RMSE, NRMSE, RSR, and MAE; categories; and Ranking and Grading System (RGS). The resulting high values of R
2
, RSR, RGS, and lowest values of NSE, PBIAS, RMSE, NRMSE, and MAE for the improved models (M5-M7) reveal that improved models performed better than the existing models (M1-M4). Similarly, based on different performance categories, all improved models exhibited superior performance in most of the watersheds than did the existing models. Sensitivity analysis indicated
CN
to be the most sensitive parameter of the improved model. The proposed model is seen to have overcome the limitations of the original and its previous versions intended for large events and can thus be used for estimating runoff more accurately.
It is environmental laws that regulate the environmental protection bodies and make them effective. With this view in mind, the article intends to examine the environmental jurisprudence in India in ...terms of evolution, pattern of delivery of environmental justice and place of people’s attitude in the process. It was found that the superior judicial bodies including National Green Tribunal have set certain norms to deal with environmental cases against the polluters (mainly government bodies and private firms), but not for day-to-day activities of the people which pollute the environment sizeably. Besides, the article, on the basis of empirical studies, finds that despite having been aware of the menace of the environmental degradation and its gravity, people are less intended to be sensitive towards the problem owing to three-pronged reasons: First, they perceive environmental protection as the sole responsibility of state; second, sizeable of them have no spare time out of their livelihood engagements; and third, lack of leadership or community action at local level for the cause. The article prima facie finds that environmental jurisprudence in India has inadequately addressed the issue of people’s say and environmentally hostile people’s attitude towards environmental protection in the process.
Many investigations have highlighted the importance of 32 indicators of RVA method and its modified framework in the evaluation of inter-annual and/or intra-annual low and high flow variability in ...river systems. Yet none of the previous investigations have taken inter-annual and intra-annual minimum e-flow variability for preserving aquatic organisms, especially in dry periods. To this end, this study proposed a procedure which consisted of modified 72 hydrologic indicators and Tennant method and applied the procedure to five sub-watersheds of Damodar catchment, India. Results showed (1) high intra-annual and inter-annual variability of all indicators within water years; (2) that none of the studied watersheds met the 10% minimum flow criterion for poor habitat conditions as recommended by Tennant method in dry years and as well as most of time none of the watersheds exhibited the availability of assured e-flow in all water years; and (3) that aquatic organisms of the catchment would become more vulnerable in the future.
The dawn of 21st century has witnessed some new features of democratic politics that seem to be shifting away from what we call democratic. The impact of globalisation has created such a nexus among ...elites of politics–corporates–media that has made political regimes to ignore the democratic norms and well-being of common masses and overemphasise economic growth and corporate-friendly policy priorities. Besides, the approach of the political actors (parties and politicians), in the process of power-seeking, has shown unconventional trends. These features do not resemble either dictatorship or totalitarianism; rather they depict trends of aristocratic mode of decision-making by using democratic framework and institutions. Such trends have been termed as ‘post-democracy’ by recent Western scholarship.
Indian politics is not an exception. These trends have created an imbalance between interest of social classes and corporative interests which has prompted political regimes to take tough decisions, in despotic ways. Though the present article does not posit that Indian democracy is on the brink, it attempts to underline the post-democratic features visible in Indian politics through examination of (a) party politics in terms of democratic framework, ideology, policy initiations and reforms, electioneering, etc.; (b) politicians–corporates–media nexus; and (c) modes and trends of politicians in communicating and relating with the electorate.
In this study, environmental flows (EFs) are estimated for six watersheds of Damodar River Basin (DRB) using flow duration curve (FDC) derived using two approaches: (a) period of record and (b) ...stochastic approaches for daily, 7-, 30-, 60-day moving averages, and 7-daily mean annual flows observed at Tenughat dam, Konar dam, Maithon dam, Panchet dam, Damodar bridge, Burnpur during 1981–2010 and at Phusro during 1988–2010. For stochastic FDCs, 7-day FDCs for 10, 20-, 50- and 100-year return periods were derived for extraction of discharge values at every 5% probability of exceedance. FDCs derived using the first approach show high probability of exceedance (5–75%) for the same discharge values. Furthermore, discharge values of 60-day mean are higher than those derived using daily, 7-, and 30-day mean values. The discharge values of 95% probability of exceedance (Q95) derived from 7Q10 (ranges from 2.04 to 5.56 cumec) and 7Q100 (ranges from 3.4 to 31.48 cumec) FDCs using the second approach are found more appropriate as EFs during drought/low flow and normal precipitation years.
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