The unnatural L-1,1-a-disaccharides were synthesized from acylfurans using a palladium-catalyzed glycosylation reaction. The 1,1-a-manno-disaccharides were achieved in six total steps starting from ...an acylfuran. The overall efficiency of this protocol was the use of highly diastereoselective palladium-catalyzed glycosylation, reduction, and dihydroxylation.
A series of new quinoxaline-1,2,4-thiadiazoles amide hybrids has been synthesized and evaluated for their anti-proliferative activity on four different human cancer cell lines including HeLa ...(breast), A549 (lung), MCF-7 (breast), and HEK-293 (embryonic kidney) using etoposide as a standard drug. Three synthesized compounds exhibit promising anticancer activity. One of those demonstrates higher potency against all cell lines than etoposide. Two products exhibit promising inhibitory activity over tyrosine kinase EGFR.
In the current study, some new quinoxaline linked 1,3,4-oxadiazole sulfonamide hybrids have been designed, synthesized and characterized by IR,
1
H and
13
C NMR, and mass spectra. The products have ...been evaluated for their in vitro anti-proliferative activity against four human cancer cell lines, namely HeLa (cervical), A549 (lung), MCF-7 (breast), HEK-293 (embryonic kidney). Three compounds have demonstrated high anticancer activity when compared with Etoposide used as a reference drug.
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