Onychomycoses are difficult‐to‐treat fungal infections with a high recurrence rate that relates to the anatomic and pathophysiological conditions in the nail organ and the required extended duration ...of treatment. Clinical‐epidemiological studies demonstrated that non‐dermatophyte molds and yeasts are the primary causative agents in 20%–30% of onychomycoses. Mixed infections with dermatophytes are observed as well. Therefore, the causative agents should be determined by fungal culture and the antifungal treatment regimen should reliably cover non‐dermatophytes, if appropriate. Systemic‐topical combination therapy involving a broad‐spectrum, locally applied antifungal may increase the mycological and clinical cure rates compared to monotherapy with systemic drugs.
