Background: One of the cutaneous reactions associated with tattoos is sarcoidosis and the most frequent presentation is systemic involvement; within this, the manifestation of uveitis and sarcoidal ...reactions associated with tattoos is little described. Clinical case: A 27-year-old man with a clinical picture of six months of evolution consisting of general malaise, subjective fever, chills, myalgias, arthralgias, cough with hemoptysis, edema in lower limbs, and in whom red eye, diminution of visual acuity, and papules that infiltrated one of the tattoos that were placed, six months earlier, on the right arm and left forearm, were found. Conclusion: Sarcoidosis associated with tattooing is a disease that requires a high index of suspicion, where its infiltration should make the clinician suspect the disease and make an active search for systemic involvement, especially in a patient with a uveal compromise that can lead to blindness. It must keep in mind that, although rare, this triple association is possible (tattoo, systemic sarcoidosis, and panuveitis).
One of the limitations of implementing animal breeding programs in small-scale or extensive production systems is the lack of production records and genealogical records. In this context, molecular ...markers could help to gain information for the breeding program. This study addresses the inclusion of molecular data into traditional genetic evaluation models as a random effect by molecular pedigree reconstruction and as a fixed effect by Bayesian clustering. The methods were tested for lactation curve traits in 14 dairy goat herds with incomplete phenotypic data and pedigree information. The results showed an increment of 37.3% of the relationships regarding the originals with MOLCOAN and clustering into five genetic groups. Data leads to estimating additive variance, error variance, and heritability with four different models, including pedigree and molecular information. Deviance Information Criterion (DIC) values demonstrate a greater fitting of the models that include molecular information either as fixed (genetic clusters) or as random (molecular matrix) effects. The molecular information of simple markers can complement genetic improvement strategies in populations with little information.
Studies that have compared the cognitive alterations of the children of parents with bipolar disorder (CPBD) versus the children of control parents (CCP), present heterogeneous results due to the ...studies' methodological differences, the age of the population studied, and the lack of standardisation of the measures used for the different neurocognitive domains. The objective was to compare the neurocognitive profile of CPBD versus CCP to observe if there are differences that could be proposed as possible endophenotypes of BD.
A total of 107 individuals (51 CPBD, and 56 CCP) with ages between 6 and 16 (mean, 12.2±2.80) years of age were evaluated. Seventy-four point five percent of the CPBD group had some disorder compared to 67.9% of the CCP group. Tests such as letter-F phonemic verbal fluency, letter-S phonemic verbal fluency, overall F-A-S phonemic verbal fluency, story recall and retrieval, and Wisconsin perseverative errors showed a difference with a small effect size, but with a high degree of uncertainty.
The CPBD did not have differences in their neurocognitive profile in comparison with CCP. Both groups have a high prevalence of psychopathology, which is a factor that could explain the lack of differences in neurocognitive performance.
Introducción: El conocimiento relacionado con la disponibilidad de los principales grupos de alimentos y sus aportes de energía, proteína y grasa, es de vital importancia por parte de entes ...gubernamentales y privados, con el fin de diagnosticar el potencial alimenticio de una región.Material y Métodos: Se utilizó análisis multivariado de la varianza (MANOVA) con contraste canónico de tipo ortogonal, análisis de componentes principales, análisis descriptivo exploratorio de tipo unidimensional y análisis Biplot, donde se tuvo en cuenta una base de datos proveniente de la FAO relacionada al suministro medio disponible de energía, proteína y grasa por persona/día de los principales grupos de alimentos en el período comprendido de 1961 a 2010 en México. Dichos datos representan únicamente el suministro medio disponible para la población total y no indican necesariamente consumo real.Resultados: Durante el período de análisis el suministro de carne de ave fue el de mayor aumento, pasando de 10,4g/persona/día a 71,2g/persona/día. Caso contrario al maíz y el frijol, los cuales tuvieron una disminución de 1% y 49% respectivamente. El mayor suministro de energía y proteína lo aportó la leche con 130kcal/persona/día y 7,5g/persona/día de proteína. El mayor aporte de grasa se dio por parte de la carne de cerdo, con 10,8g/persona/día.Conclusiones: Si bien se nota un crecimiento de suministro de vegetales, frutas y hortalizas, este tiene una proporción menor al de la carne, por lo que se debe reorganizar la dieta de los mexicanos por una que contenga aportaciones óptimas para una dieta equilibrada.
Sarcoidosis is a systemic granulomatous disease of unknown etiology. It affects patients of all types and ages, being more frequent between the third and fourth decade of life with a second peak ...around fifth decade in the Scandinavian and Japanese populations. It is more common in women and severe in the Afro-descendant population. Antigens that initiate this granulomatous response are unknown, however, they are presumed to be airborne as a result of the lung involvement high frequency in this disease. Its clinical manifestation covers a wide range of manifestations, including acute and limited forms to chronic with progressive organ damage and death. Its diagnosis is based on the existence of non-caseating granulomas in tissues, excluding other diseases such as mycobacterial infection. KEYWORDS Lymphadenopathy; Lung; Sarcoidosis Sarcoidosis: muchas caras, una enfermedad. Revision narrativa de la literatura La sarcoidosis es una enfermedad granulomatosa sistemica de etiologia desconocida. Esta puede afectar a pacientes de todas las latitudes y edades, siendo mas frecuente entre la tercera y cuarta decada de la vida con un segundo pico alrededor de los 50 anos en las poblaciones escandinava y japonesa. Es mas frecuente en mujeres y grave en la poblacion afrodescendiente. Los antigenos que inician esta respuesta granulomatosa son desconocidos, pero se presume que son aerotransportados por la alta frecuencia de compromiso pulmonar en esta enfermedad. Su presentacion clinica abarca una amplia gama de manifestaciones, desde formas agudas y limitadas hasta el compromiso cronico con dano organico progresivo y muerte. Su diagnostico se basa en la existencia de los granulomas no caseificantes en los tejidos, con la exclusion de otras enfermedades, entre ellas infeccion por micobacterias. PALABRAS CLAVE Linfadenopatia; Pulmon; Sarcoidosis
Considering the significant morbidity and mortality of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc) and the lack of precise information on disease in Latin America, ...we investigated the clinical and laboratory characteristics associated with PAH in Colombian patients with SSc and review the literature.
This multicenter study included patients followed at 5 rheumatology units that were systematically assessed using a pretested questionnaire on clinical and immunological variables, focusing on PAH. Conditional logistic regression was employed to assess association between PAH and specific clinical characteristics. A systematic review of the literature was performed through electronic databases.
Of a total of 349 patients with SSc, 61 (17%) met the criteria for PAH. Pulmonary fibrosis adjusted odds ratio (AOR) 7.37, 95% CI 3.67-14.81, p < 0.0001, microstomia (AOR 3.3, 95% CI 1.70-6.28, p < 0.0001), gastroesophageal reflux (AOR 2.41, 95% CI 1.31-4.43, p = 0.005), dysphagia (AOR 2.7, 95% CI 1.49-4.77, p = 0.001), hyperpigmentation (AOR 2.15, 95% CI 1.11-4.16, p = 0.02), and hypopigmentation (AOR 2.4, 95% CI 1.26-4.64, p = 0.008) were the most prevalent clinical characteristics associated with PAH, while anemia (AOR 5.4, 95% CI 1.98-14.93, p = 0.001) was observed as the unique laboratory risk factor. Association between subtypes of SSc and PAH was not observed. Significant differences in both clinical and laboratory data were observed among different series.
PAH may be a frequent complication of SSc in the Colombian population regardless of disease subtype. The identified clinical and laboratory risk factors might assist earlier diagnosis and guide decisions on therapeutic interventions on this critical complication of SSc. The reasons underlying the reported divergences among patients from different ethnicities are not fully understood, but it is most likely that both genetic and environmental factors are responsible for them.
Propylene glycol, also known as 1,2 propanediol, is one of the most important chemicals in the industry. It is a water-soluble liquid, considered by the U.S. Food and Drug Administration as safe to ...manufacture consumer products, including foodstuffs, medicines, and cosmetics. This chemical has essential properties, such as solvent, moisturizer, or antifreeze, in addition to a low level of toxicity. This paper aims to present the selection, simulation, and dimensioning of a trickle bed reactor at a laboratory scale. The sizing was validated with other authors. Two predictive models have been considered for reactor modeling, intrinsic kinetics and coupled intrinsic kinetics, along with mass transfer equations and the wetting of the catalyst particles. The model was implemented using Aspen Custom Modeler® (20 Crosby Dr. Bedford, MA 01730, EE. UU.) to study the reactor behavior in terms of conversion. The results show the profiles of different variables throughout the reactor and present higher glycerol conversion when mass transfer is added to the model.
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