As the internet develops and 5G technology becomes increasingly prominent, the internet has become a major source of health-related information. Increasingly, people use the internet to find ...health-related information, and digital health literacy is now a set of essential capabilities to improve their health in the digital era. However, little is known about the factors that influencing digital health literacy. This study aimed to assess digital health literacy scores and identify its influencing factors among internet users in China. Additionally, this study explored the participant's actual skills using an additional set of performance-based items from the Digital Health Literacy Instrument (DHLI).
An online cross-sectional study was conducted in August 2022. Participants aged ≥18 years were recruited to complete the survey. Data were collected using the Chinese revised version of the DHLI, the self-reported internet use questionnaire, and the sociodemographic questionnaire. We conducted multivariate linear regression analyses to explore the relationships among the sociodemographic variables, behavior of internet use, and the digital health literacy scores.
In total, 702 participants completed the survey. The mean DHLI score was 2.69 ± 0.61. Multivariate linear regression analyses showed that the age groups 35-49 (β = - 0.08, P = 0.033), 50-64 (β = - 0.161, P < 0.001), and ≥ 65 (β = - 0.138, P < 0.001) were negatively associated with DHL scores. However, education level, including bachelor's or associate degree (β = 0.255, P = 0.002) and master's degree and above (β = 0.256, P < 0.001), frequency of health-related Internet usage (β = 0.192, P < 0.001), the number of digital devices used (β = 0.129, P = 0.001), and OHISB (β = 0.103, P = 0.006) showed a positive relationship with DHL scores.
The study findings demonstrate that age, educational levels, number of technological devices used, and greater use of the web for health information were independently associated with DHL scores. Healthcare providers should consider providing training programs tailored to specific sociodemographic factors to improve the ability that find and use accurate information online to meet digital health services, which contributes to enhance their self-management and reduce health disparities.
Lack of efficiency has been a major problem shared by all currently developed anti-SARS-CoV-2 therapies. Our previous study shows that SARS-CoV-2 structural envelope (2-E) protein forms a type of ...cation channel, and heterogeneously expression of 2-E channels causes host cell death. In this study we developed a cell-based high throughput screening (HTS) assay and used it to discover inhibitors against 2-E channels. Among 4376 compounds tested, 34 hits with cell protection activity were found. Followed by an anti-viral analysis, 15 compounds which could inhibit SARS-CoV-2 replication were identified. In electrophysiological experiments, three representatives showing inhibitory effect on 2-E channels were chosen for further characterization. Among them, proanthocyanidins directly bound to 2-E channel with binding affinity (K
) of 22.14 μM in surface plasmon resonance assay. Molecular modeling and docking analysis revealed that proanthocyanidins inserted into the pore of 2-E N-terminal vestibule acting as a channel blocker. Consistently, mutations of Glu 8 and Asn 15, two residues lining the proposed binding pocket, abolished the inhibitory effects of proanthocyanidins. The natural product proanthocyanidins are widely used as cosmetic, suggesting a potential of proanthocyanidins as disinfectant for external use. This study further demonstrates that 2-E channel is an effective antiviral drug target and provides a potential antiviral candidate against SARS-CoV-2.
(-)-Naringenin 4',7-dimethyl ether ((-)-NRG-DM) was isolated for the first time by our lab from
DC, a traditional medicinal plant frequently used to attenuate pain in Asia. As a natural derivative of ...analgesic, the current study was designed to test the potential analgesic activity of (-)-NRG-DM and its implicated mechanism. The analgesic activity of (-)-NRG-DM was assessed in a formalin-induced mouse inflammatory pain model and mustard oil-induced mouse colorectal pain model, in which the mice were intraperitoneally administrated with vehicle or (-)-NRG-DM (30 or 50 mg/kg) (
= 10 for each group). Our data showed that (-)-NRG-DM can dose dependently (30~50 mg/kg) relieve the pain behaviors. Notably, (-)-NRG-DM did not affect motor coordination in mice evaluated by the rotarod test, in which the animals were intraperitoneally injected with vehicle or (-)-NRG-DM (100, 200, or 400 mg/kg) (
= 10 for each group). In acutely isolated mouse dorsal root ganglion neurons, (-)-NRG-DM (1~30 μM) potently dampened the stimulated firing, reduced the action potential threshold and amplitude. In addition, the neuronal delayed rectifier potassium currents (I
) and voltage-gated sodium currents (I
) were significantly suppressed. Consistently, (-)-NRG-DM dramatically inhibited heterologously expressed Kv2.1 and Nav1.8 channels which represent the major components of the endogenous I
and I
. A pharmacokinetic study revealed the plasma concentration of (-)-NRG-DM is around 7 µM, which was higher than the effective concentrations for the I
and I
. Taken together, our study showed that (-)-NRG-DM is a potential analgesic candidate with inhibition of multiple neuronal channels (mediating I
and I
).
Abstract
We did 194 epochs of simultaneous 2.25/8.60 GHz observations of XTE J1810−197 in 926 days shortly following its reactivation in 2018 with Shanghai Tian Ma Radio Telescope (TMRT). Although ...its integrated profiles changed with both time and frequency during this period, they could be classified into 12 types according to phase areas of active radiation components. After MJD 59015, XTE J1810−197 turned from the normal emission state into the spiky emission state that was manifesting as a series of bright narrow sub-pulse bursts at both 2.25 and 8.60 GHz. Due to its variable integrated profiles and unsteady rotations, we got the spin frequency
ν
and spin-frequency derivatives
ν
̇
with the piecewise fitting method. In addition, its long-term declining trend of
ν
was also obtained as
ν
̇
=
−
3.2
(
1
)
×
10
−
13
s
−2
with the linear fitting method based on our observations spanning a comparatively longer period. We found its flux densities went through three stages: sharp decrease, stabilization, and day-to-day fluctuations in our dual-frequency observations. Although the flux density showed different stages, XTE J1810−197 showed a relatively flat spectrum (
α
> –1) in most observations. Assuming an ideal dipole magnetic field as some previous research works, we obtained the emission heights of XTE J1810−197 were about 7.5(9) × 10
4
km and 2.38(7) × 10
4
km at 2.25 and 8.60 GHz, respectively. We also found that its emission heights would decrease rapidly with the degree of magnetic field twisting.
Abstract
We report detection results of nine millisecond pulsars (MSPs) at 8600 MHz using simultaneous 2250 and 8600 MHz observations conducted with the Shanghai Tian Ma Radio Telescope. Mainly ...benefiting from updated ephemerids with 2250 MHz observations, integrated profiles of all nine MSPs at 8600 MHz are successfully obtained by coherently adding multi-epoch (3–83 epochs) observation data spanning from 19–1210 days, which significantly increases the number of MSPs with published profiles (from 4 to 11) above 8000 MHz, as seven of our target MPSs had no related results previously. Combining our new flux density and pulse width measurements with previous low-frequency results, we study their integrated profile evolution and spectral behaviors in a wider frequency range. We find their component separations and pulse widths remain almost constant, which is consistent with previous findings. While dramatic evolution of integrated profiles exists at low frequencies, we observe a potential end of the related evolution around 5 GHz in eight MSPs. The spectra of four MSPs are found to deviate from a single power law, and we fit them with a broken power law. The change in the profile of PSR J1713+0747, which started around MJD 59320−59321, seems to be more prominent as the observation frequency increases. Compared with the effects of the interstellar medium, we prefer to explain this event as some changes in the magnetosphere. We also find its integrated profile possibly had not recovered to the pre-event state until MJD 59842–59857.
is an edible cyanobacterium with excellent food and herbal values. It has been used as food in China for more than 2000 years. Many studies have been focused on improving the yield and bioactivity of
...polysaccharides although these have ignored the functional properties. In this study, we extracted and purified three polysaccharides (WL-CPS, NaCl-CPS and Glu-CPS) from
under normal, salt stress and mixotrophic culture conditions, respectively, in order to change the physicochemical properties of polysaccharides with the aim of obtaining better functional properties. Both salt stress and mixotrophic culture conditions increased the specific yield of polysaccharides. Their functional properties were comparatively investigated and the results showed that NaCl-CPS exhibited the highest emulsification activity and flocculation capability, which was also higher than that of some commercial products. In contrast, Glu-CPS exhibited the highest water and oil holding capacities, foaming property, intrinsic viscosity and bile acids binding capacity. Our results indicated that both NaCl-CPS and Glu-CPS could be considered to be functional polysaccharides according to their respective characteristics, which have great potential in numerous applications, such as food, pharmaceutical, cosmetic, chemical and mineral industries. These findings also demonstrated the potential application of the proper regulation of culture conditions in the development of polysaccharides with desired functional properties.
Parenting sense of competence is not only indispensable to the wellbeing of the parents of premature infants, but is also pivotal to the overall development of these infants. This study examined the ...level of parenting sense of competence and its associated factors in Chinese parents of preterm infants.
This cross-sectional study was performed at a university teaching hospital in Fuzhou (China) from December 2021 to April 2022. Data were collected using the Parenting Sense of Competence Scale, Edinburgh Postnatal Depression Scale, Social Support Rating Scale, Parenting Care Knowledge Subscale, Parenting Care Skill Subscale, and a sociodemographic questionnaire.
A total of 401 Chinese parents were included in the analysis. The average parenting sense of competence scale score was 70.93 ± 13.06. After controlling for demographic characteristics, parenting knowledge (β = 0.149, P = 0.013), parenting skills (β = 0.241, P < 0.001), social support (β = 0.184, P < 0.001) and depression (β = -0.272, P < 0.001), were significantly associated with the parenting sense of competence score, and explained 43.60% of the variance in this score.
Chinese parents of preterm infants were found to have a moderate parenting sense of competence. This could be further improved through efforts aimed at reducing depressive symptoms and increasing parenting knowledge, parenting skills, and social support.
ABSTRACT We report Shanghai Tian Ma Radio Telescope (TMRT) detections of several long carbon-chain molecules in the C and Ku bands, including HC3N, HC5N, HC7N, HC9N, C3S, C6H, and C8H toward the ...starless cloud Serpens South 1a. We detected some transitions (HC9N J = 13-12, F = 12-11, and F = 14-13; H13CCCN J = 2-1, F = 1-0, and F = 1-1; HC13CCN J = 2-1, F = 2-2, F = 1-0, and F = 1-1; HCC13CN J = 2-1, F = 1-0, and F = 1-1) and resolved some hyperfine components (HC5N J = 6-5, F = 5-4; H13CCCN J = 2-1, F = 2-1) for the first time in the interstellar medium. The column densities of these carbon-chain molecules in the range 1012-1013 cm−2 are comparable to two carbon-chain molecule rich sources, TMC-1 and Lupus-1A. The abundance ratios are 1.00:(1.11 0.15):(1.47 0.18) for H13CCCN:HC13CCN:HCC13CN. This result implies that the 13C isotope is also concentrated in the carbon atom adjacent to the nitrogen atom in HC3N in Serpens South 1a, which is similar to TMC-1. The HC3N/H13CCCN ratio of 78 9, the HC3N/HC13CCN ratio of 70 8, and the HC3N/HCC13CN ratio of 53 4 are also comparable to those in TMC-1. Serpens South 1a proves to be a suitable testing ground for understanding carbon-chain chemistry.
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